... antibody), and a standard metabolic/inborn error panel (lactate/pyruvate ratio, urine and serum organic acids and amino acids) The REP master diagnostic index identified a total of 130 cases After ... re-transplantation 2.3 years after the first liver transplant procedure Finally, she died from multiple organ failure at age 27 years The two deaths recorded were both nonliver related, and none of these ... progresses as an ascending genital tract infection affecting both pelvic and adjacent abdominal organs.2 It is estimated that actinomycosis is present in 10% of asymptomatic IUCD users; this rises...
... membrane-bound forms [14] Alternatively, soluble molecules can trigger responses in cells that bear their ligands [15] Moreover, because the levels of these adhesion molecules change in different states, ... Hwang ST, Singer MS, Giblin PA, Yednock TA, Bacon KB, Simon SI, Rosen SD: GlyCAM-1, a physiologic ligand for L-selectin, activates b integrins on naïve peripheral lymphocytes J Exp Med 1996, 184:1343-8...
... disease [13,14] Notably, endotoxin seems to promote liver fibrogenesis by stimulating TLR4, as elegantly shown in three different mouse models of liver fibrosis [23] In the present study, endotoxin ... Pritlove DC, Ranasinghe AM, da Silva NF, Youssef EM, Khunti K, Davies MJ, Bonser RS, Kumar S, Pagano D, McTernan PG: Epicardial Adipose Tissue as a Source of Nuclear Factor-{kappa}B and c-Jun...
... disease [13,14] Notably, endotoxin seems to promote liver fibrogenesis by stimulating TLR4, as elegantly shown in three different mouse models of liver fibrosis [23] In the present study, endotoxin ... Pritlove DC, Ranasinghe AM, da Silva NF, Youssef EM, Khunti K, Davies MJ, Bonser RS, Kumar S, Pagano D, McTernan PG: Epicardial Adipose Tissue as a Source of Nuclear Factor-{kappa}B and c-Jun...
... lead to NAFLD In vitro and in vivo studies have shown that lipoprotein-bound apoE is the natural ligand for LDLr [26,32], which is the main receptor involved in the clearance of apoE-containing lipoproteins...
... transcription factor, peroxisome proliferators-activated receptor-γ (PRAPγ), by binding selective ligands.[90] The first drug, troglitazone, showed promising therapeutic effects in patients with NAFLD.[91] ... Bacon BR Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-gamma ligand rosiglitazone Hepatology 2003;38:1008-1017 92 Marchesini G, Brizi M, Bianchi G, Tomassetti...
... the emerging role of the adipocyte as an endocrine organ N Engl J Med 2001; 345: 1345–6 126 Ahima RS, Filer JS Adipose tissue as an endocrine organ Trends Endocrinol Metab 2000; 11: 327–32 127 Katsuki ... risk factors for hepatic steatosis in northern Italy Ann Intern Med 2000; 132: 112–7 33 Hasan I, Gani RA, Machmud R et al Prevalence and risk factors for non-alcoholic fatty liver in Indonesia ... hypersecretion and specific association with the insulin resistance syndrome Hepatology 2002; 35: 373–8 40 Pagano G, Pacini G, Musso G et al Non-alcoholic steatohepatitis, insulin resistance and metabolic...
... urbanization and globalization of lifestyle Global Trends in Childhood Obesity The World Health Organization states “An escalating global epidemic of overweight and obesity– “globesity”– is taking ... consequences of childhood obesity: a Hong Kong perspective Res Sports Med 2010;18(1):16-25 World Health Organization Controlling the global obesity epidemic Geneva, Switzerland: WHO; 2008 [updated 2011...
... significant Results Survival rate Survival analysis showed that the mice in the alcohol-fed group began to die at the first week of alcohol administration, with a survival of 24.07 ± 3.21% after weeks ... in rats via PPAR-alpha and SREBP-1c signaling Lipids Health Dis 2010, 9:25 46 Schwarz JM, Mulligan K, Lee J, Lo JC, Wen M, Noor MA, Grunfeld C, Schambelan M: Effects of recombinant human growth...
... interleukin-6 concentrations in alcoholic hepatitis J Lab Clin Med 1992, 119:547-552 11 Unlu M, Morgan ME, Minden JS: Difference gel electrophoresis: a single gel method for detecting changes in ... (2D-DIGE) approach J Proteome Res 2007, 6:4440-4448 16 Keshavarzian A, Farhadi A, Forsyth CB, Rangan J, Jakate S, Shaikh M, Banan A, Fields JZ: Evidence that chronic alcohol exposure promotes intestinal ... in humans J Clin Endocrinol Metab 2004, 89:2678-2683 32 Shu H, Kang X, Guo K, Li S, Li M, Sun L, Gan L, Liu Y, Qin X: Diagnostic value of serum haptoglobin protein as hepatocellular carcinoma candidate...
... Bath Commissioning Editor: Alison Brown Managing Editor: Rupal Malde Production Editor: Nick Morgan Project Manager: Sue Hadden Production Controller: Kate Charman For further information on Blackwell ... risk factors for hepatic steatosis in northern Italy Ann Intern Med 2000; 132: 112–7 33 Hasan I, Gani RA, Machmud R et al Prevalence and risk factors for non-alcoholic fatty liver in Indonesia ... hypersecretion and specific association with the insulin resistance syndrome Hepatology 2002; 35: 373–8 40 Pagano G, Pacini G, Musso G et al Non-alcoholic steatohepatitis, insulin resistance and metabolic...
... (and see Chapter 24) References World Health Organization Preventing and Managing the Global Epidemic: Report of a WHO Consultation World Health Organization, WHO Technical Report Series 894, 2000 ... clear-cut assessment The first attempt to define the metabolic syndrome came from the World Health Organization (WHO) The expert committee setting new criteria for the definition of diabetes proposed ... secretion and specific association with the insulin resistance syndrome Hepatology 2002; 35: 373–9 11 Pagano G, Pacini G, Musso G et al Non-alcoholic steatohepatitis, insulin resistance, and metabolic...
... AOX ko, acetylCoA oxidase knockout mouse; CYP, cytochrome P450; FFA, free fatty acids; MnSOD, manganese-superoxide dismutase; mt, mitochondrial; ROS, reduced (reactive) oxygen species; NO, nitrous ... steatosis [26]; these changes can be reversed by administration of ragaglitazar, a combined PPARα–γ ligand [27] The latter studies also invoked a role for adiponectin, another adipocyte-derived insulin-sensitizing ... to correspond to NAFLD type rather than types or (NASH) (see Chapters and 2) In a series of elegant experiments, Diehl et al have studied pathogenesis of NAFLD in ob/ob mice [32,33,35– 41] Early...
... Fas ligand, preventing them from killing their neighbours [38] However, several conditions leading to increased ROS formation, such as drugs, alcohol abuse or Wilson’s disease, cause Fas ligand ... the import of human manganese superoxide dismutase into rat liver mitochondria Pharmacogenetics 2003; 13: 145–57 Stewart SF, Leathart JB, Chen Y et al Valine-alanine manganese superoxide dismutase ... Death receptors, mitochondria and apoptosis In hepatocytes, ROS trigger the expression of Fas ligand (Fas L) and TNF-α The latter is also formed by the adipocytes of obese subjects and by endotoxin-stimulated...
... values in asymptomatic patients Scand J Gastroenterol 1999; 34: 85–91 Morgan W The Liver and its Diseases, Both Functional and Organic: Their History, Anatomy, Chemistry, Pathology, Physiology, and ... 1183–92 World Health Organization Definition, diagnosis and classification of diabetes and its complications I Diagnosis and classification of diabetes Geneva: World Health Organization, 1999: 20–1 ... cirrhosis Hepatology 2002; 35: 1485–93 24 World Health Organization Obesity: Preventing and Managing the Global Epidemic Geneva: World Health Organization, 1998 25 International Diabetes Institute...
... primary non-function or poor early graft function The mechanisms whereby steatosis of the donor organ leads to PNF are not understood completely, but several have been proposed [9,10]: Diminished ... months They compared patients with and without diabetes (defined according to the World Health Organization criteria: fasting blood glucose level > 7.8 mmol/L, or the preoperative requirement for ... are not at increased risk [34,35] In contrast, Nair et al [23] reviewed the United Network for Organ Sharing (UNOS) database and described the recorded outcomes in 2966 patients with a BMI > 30...
... acid metabolism, glycogen storage and the urea cycle may be excluded with a urine screen for organic acids and a serum amino acid profile Children younger than years with steatohepatitis should ... that the liver injury is, in most instances, part of complex functional disturbances and multiorgan injury (Table 20.1) Pathological spectrum of jejuno-ileal bypass-induced liver disease Polyarthralgia ... liver leading to cirrhosis has also been reported [46,48] Familial partial lipodystrophy The Dunnigan variety of familial partial lipodystrophy (FPLD) usually occurs in female patients [47] This...
... genetics 67 family history cryptogenic cirrhosis 176 NAFLD/NASH 160–161 Fas-Fas ligand interaction 139–140 Fas ligand expression, reactive oxygen species 139 fasting acetyl-CoA 133 free fatty acid ... change in NAFLD (Letter) Hepatology 2004; 39: 1458–9 Loria P, Lonardo A, Leonardi F et al Non-organ-specific autoantibodies in nonalcoholic fatty liver disease: prevalence and correlates Dig Dis ... D, Bacon BR Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-γ ligand rosiglitazone Hepatology 2003; 38: 100817 62 Promrat K, Lutchman G, Uwaifo GI et al A pilot...