... rheumatoidarthritis Nat Genet 2003, 35:341-348 John S, Eyre S, Myerscough A, Barrett J, Silman A, Ollier W, Worthington J: Linkage and association analysis of candidate genes in rheumatoidarthritis ... of the PD1.3 A allelle of the PDCD1 gene in patients with rheumatoidarthritis negative for rheumatoid factor and the shared epitope Arthritis Rheum 2004, 50:1770-1773 Helms C, Cao L, Krueger ... bone formation and repair, and it is of particular interest when considering the susceptibility to response to treatment of patients with rheumatoidarthritis or to disease severity and damage 10...
... failure in rheumatoidarthritis Fewer statistics on incidence and prevalence rates for CHF in patients with RA are available and are derived from a handful of population-based [24-26] and clinic-based ... failure in rheumatoid arthritis: A population-based study over 46 years Arthritis Rheum 2005, 52:412-420 Wolfe F, Michaud K: Heart failure in rheumatoid arthritis: Rates, predictors, and the effect ... metabolic syndrome features in rheumatoidarthritisArthritis Res 2002, 4:R5 Svenson KLG, Pollare T, Lithell H, Hallgren R: Impaired glucose handling in active rheumatoid- arthritis: Relationship to...
... Silman AJ: The pill, parity, andrheumatoidarthritisArthritis Rheum 1990, 33:782-789 Kay A, Bach F: Subfertility before and after the development of rheumatoidarthritis in women Ann Rheum ... purposes) Arthritis Research & Therapy Vol No Pedersen et al Table (Continued) Tobacco smoking, coffee and alcohol intake, body mass index, physical activity, and pets and risk of rheumatoid arthritis, ... purposes) Table Non-genetic factors and risk of anti-CCP-positive and anti-CCP-negative rheumatoid arthritis, Denmark 1998 to 2003 Anti-CCP-positive rheumatoidarthritis Number of patients/controls...
... TNF-α gene, between nucleotides -1,318 and +49, of 554 patients with RA from 11 Portuguese rheumatology centers serving the mainland and Azores and Madeira Islands An association was found between ... the 238, -308, -857, and -863 positions, and systemic manifestations, functional status, radiological damage, work disability, and joint surgeries and between haplotypes and radiological damage ... for the classification of rheumatoidarthritisArthritis Rheum 1988, 31:315-324 Fonseca JE, Canhão H, Reis P, Jesus H, Pereira da Silva JA, Viana Queiroz M: [Rheumatoid arthritis clinical protocol]...
... the Treatment of RheumatoidArthritis of Early Onset Study Group: Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: a randomized, controlled trial Arthritis Rheum ... with rheumatoidarthritisArthritis Rheum 2004, 50:1390-1399 Landewe RB, Geusens P, Van der Heijde DM, Boers M, van der Linden SJ, Garnero P: Arthritis instantaneously causes collagen type I and ... acute phase proteins in rheumatoidarthritis Scand J Rheumatol Suppl 1994, 100:9-19 Otterness IG: The value of C-reactive protein measurement in rheumatoidarthritis Semin Arthritis Rheum 1994,...
... Lipoxygenase enzymes in rheumatoidarthritisandosteoarthritis synovial tissue 5-Lipoxygenase (5-LO) and 15-LO-1 enzymes are present in both tissue rheumatoidarthritis (RA) andosteoarthritis (OA) synovial ... synovial tissue and clinical improvement in rheumatoidarthritisArthritis Rheum 2004, 50:3783-3791 49 Harris ED Jr: Prednisolone in early rheumatoid arthritis: an antiinvasive effect Arthritis Rheum ... expression in rheumatoidarthritis synovial fluid cells and 15-hydroxyeicosatetraenoic acid production Rheumatoidarthritis (RA) production synovial fluid cells express 15-lipoxygenase-1 (15-LO-1) and...
... in rheumatoidarthritis Clin Exp Rheumatol 2007, 25:S4-11 Miossec P: Dynamic interactions between T cells and dendritic cells and their derived cytokines/chemokines in the rheumatoid synovium Arthritis ... strategy in the treatment of rheumatoid arthritis? Arthritis Res Ther 2005, 7:S15-20 Buch MH, Vital EM, Emery P: Abatacept in the treatment of rheumatoidarthritisArthritis Res Ther 2008, 10:S5 ... Ther 2008, 10:S2 Olsen NJ, Stein MC: New drugs for rheumatoidarthritis N Engl J Med 2004, 350:2167-2179 Abbott JD, Moreland LW: Rheumatoid arthritis: Developing pharmacological therapies Expert...
... hypoxia inducible factor; OA, osteoarthritis; RA, rheumatoidarthritis OA RA HIF-2α Overexpression of hypoxia inducible factor (HIF)-1α and HIF-2α in osteoarthritic (OA) andrheumatoid arthritic (RA) ... of a dense, viable and hyperpermeable vascular system RHEUMATOID PATHOLOGY Schematic representation of the suggested pathogenetic model in osteoarthritis (OA) andrheumatoidarthritis (RA) HIF, ... necrosis factor alpha and interleukin-1 in rheumatoidarthritisArthritis Rheum 1998, 41:1258-1265 38 Szekanecz Z, Kim J, Koch AE: Chemokines and chemokine receptors in rheumatoidarthritis Semin Immunol...
... fragments and their role in inflammatory arthritis Semin Arthritis Rheum 2000, 29:252265 Peters JH, Loredo GA, Benton HP: Is osteoarthritis a “fibronectin-integrin imbalance disorder”? Osteoarthritis ... osteoarthritis (OA) [3,6–9], and fragmented forms of FN have been detected in synovial fluid (SF) and articular cartilage from patients with OA and patients with rheumatoidarthritis (RA) [10–17] On ... cluster in samples 1, 3, 4, 7, and (diagonal arrows pointing upward and to the left) (2) ~185-kDa (denoted by small brackets facing downward): OA samples and (b,d), andand (f,g) (blots/exposures...
... hyaluronanof knees in 2, and -3 and hyaluronidase-1, -2, and -3 in the synovium of knees in osteoarthritis (OA) andrheumatoidarthritis (RA) Total RNA was isolated from knee synovium and expression levels ... 2-∆average∆CT Figure osteoarthritis hyaluronidase-1, -2, and -3 in the synovium synthase-1, 2, and -3 and (OA) levels of the messages (RA) Relative expressionand rheumatoidarthritis for hyaluronanof ... HAS-1, -2, and -3 and Available online http:/ /arthritis- research.com/content/6/6/R514 Table Baseline data for subjects with osteoarthritis (OA) or rheumatoidarthritis (RA) or without arthritis...
... R650 Arthritis Research & Therapy Vol No Moore et al Results Trials Clinical reports of 31 randomised trials – 21 in osteoarthritis, in rheumatoid arthritis, and in mixed osteoarthritis or rheumatoid ... maximum daily dose, and rofecoxib was used at 25 mg daily Information for osteoarthritisandrheumatoidarthritis was combined because the number of patients in trials with rheumatoidarthritis was ... review and meta-analysis of celecoxib in osteoarthritisandrheumatoidarthritis was conducted using information from company clinical trial reports, supplied by Pfizer Ltd, of completed randomised,...
... synovial cells of three patients with rheumatoidarthritis (RA) andosteoarthritis (OA), we demonstrated that DHEA can be converted to testosterone, estrone (E1), and 17β-estradiol (E2) [17] In collagen ... substrate OA, osteoarthritis; RA, rheumatoidarthritis Other abbreviations are as given in the legend to Fig dihydrotestosterone, 5α-dihydro-ASD, 6βOH-testosterone, and small quantities of E1 and E2 ... [4-14C]androstenedione (ASD, 4androsten-3,17-dione, 1983.2 MBq/mmol), [4-14C]dehydroepiandrosterone (DHEA, 5-androsten-3β-ol-17-one, 2053 MBq/mmol), or [4-14C]testosterone (testosterone, 4androsten-17β-ol-3-one,...
... Differential expression of cathepsins B and L compared with matrix metalloproteinases and their respective inhibitors in rheumatoidarthritisand osteoarthritis: a parallel investigation by semiquantitative ... expressingwith fibrosis in osteoarthritis syno(BMP)-4 (a) and BMP-5 (b) in areas with fibrosis in osteoarthritis synovial tissue (original magnification ×20) Macrophagocytic (white arrows) and fibroblastoid ... experimental osteoarthritisOsteoarthritis Cartilage 2004, 12:627-635 Pagura SM, Thomas SG, Woodhouse LJ, Ezzat S, Marks P: Circulating and synovial levels of IGF-I, cytokines, physical function and anthropometry...
... from rheumatoidarthritisandosteoarthritis patients and organ donors Representative western blots of syndonors ovial fluid samples from asymptomatic donors (D) andosteoarthritis (OA) andrheumatoid ... markers in SF and joint changes in arthritic diseases [2-7], and have helped to identify markers that may have prognostic and/ or diagnostic value in rheumatoidarthritis (RA) andosteoarthritis (OA) ... asymptomatic donors (donor) and from osteoarthritis (OA) andrheumatoidarthritis (RA) patients detected by an OP-1 sandwich ELISA [19] The data are presented as the mean ± standard error of the mean...
... classification and reporting of osteoarthritis Classification of osteoarthritis of the knee Arthritis Rheum 1986, 29:1039-1049 24 Altman R, Alarcon G, Appelrouth D, Bloch D, Borenstein D, Brandt K, ... citation purposes) Arthritis Research & Therapy Vol No Shahrara et al Figure Rheumatoidarthritis synovial tissue (RA ST) had higher pPyk2 immunopositive cells compared to osteoarthritis (OA) ST ... to 120 Available online http:/ /arthritis- research.com/content/9/5/R112 Figure pSrc is upregulated in rheumatoidarthritis synovial tissue (RA ST) compared to osteoarthritis (OA) ST (a) RA (×200),...
... histories of osteoarthritisandrheumatoidarthritis patients included in the study Osteoarthritis Gender (number) Rheumatoidarthritis Female (18) Male (14) Female (12) Male (1) Mean age ± standard ... from osteoarthritis (n = 5) andrheumatoidarthritis (n = 4) patients FAAH activity (pmol/minute/mg protein) Tissue Control + URB597 Osteoarthritis synovium 2.8 ± 0.46 Undetectable Rheumatoidarthritis ... haematoxylin and eosin micrographs of synovium biopsies taken at osteoarthritis or rheumatoidarthritis total knee arthroplasty (a-c) Osteoarthritis: (a) category (least inflamed), (b) category 2, and...
... vial membrane and fibroblast samples Hc-gp 39, HexA and HexB gene expression in arthritis patients' synovial membrane and fibroblast samples Rheumatoidarthritis (RA) andosteoarthritis (OA) ... β-D-glucuronidase (GusB), hyaluronidase (Hyal1), and klotho genes was lower in rheumatoidarthritis (RA) andosteoarthritis (OA) synovial fibroblasts (SFs) than in RA and OA synovial membrane (SM) tissue ... α-D-mannosidase and β-D-galactosidase in serum and synovial fluid (SFl) of patients with RA andosteoarthritis (OA) On the contrary, SFl exoglycosidases (β-D-N-acetyl-glucosaminidase (NAG) and βD-glucuronidase...
... classification and reporting of osteoarthritis Classification of osteoarthritis of the knee Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association Arthritis Rheum ... 10.1186/ar3013 Cite this article as: Murata et al., Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoidarthritisandosteoarthritisArthritis Research & Therapy 2010, 12:R86 Page 14 ... secretions, and menstrual blood [15], and expected to be diagnostic and prognostic biomarkers of various cancers [14,16,17] Several cellular or tissue miRNAs associate with rheumatoid arthritis...
... Tumor necrosis factor and norepinephrine lower the levels of human neutrophil peptides 1-3 secretion by mixed synovial tissue cultures in osteoarthritisandrheumatoidarthritisArthritis Research ... tissue/cells and density of synovial neutrophils (a) Levels of human neutrophil peptides 1-3 (HNP1-3) in superfusate of synovial tissue of two patients with rheumatoidarthritis (RA) andosteoarthritis ... Figure Influence of norepinephrine (NE) and cortisol (Cort) on human neutrophil peptides 1-3 (HNP1-3) levels in patients with rheumatoidarthritis (RA) andosteoarthritis (OA) (a, b) Influence of...