protein interaction and downstream effects
Tài liệu Báo cáo khoa học: SREBPs: protein interaction and SREBPs Ryuichiro Sato doc
... 2008 FEBS 625 Protein interaction and SREBPs R Sato ing proteins, SCAP and importin-b, play an important role in determining the fate of SREBPs In the nucleus, multiple nuclear proteins form ... mitochondrial biogenesis and FEBS Journal 276 (2009) 622–627 ª 2008 The Author Journal compilation ª 2008 FEBS 623 Protein interaction and SREBPs R Sato respiration, and modulates hepatic gluconeogenesis ... Rbx1, and one of a family of F-box proteins, Fbw7 [17] Glycogen synthase kinase-3b phosphorylates serine and ⁄ or threonine residues near the ubiquitination site in SREBP-1 and SREBP-2, and SREBP...
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Mechanisms of polymer ca2+ interaction and their effects on the characteristics of alginate microspheres and films 3
... (band 1147.4 cm-1) or shifted to a lower wavenumber (band 1102.2 cm-1) in the cross-linked AP films In addition, bands at 1126.2 cm-1(C-C stretch and C-O stretch) and 1097.3 cm-1 (C-O stretch and ... strong band with increased prominence of bands between 1680-1670 cm-1 and 1417-1426 cm-1 were associated with asymmetric and symmetric COOstretching vibrations of the carboxyl groups and they ... (Figure 23) This band was also absent in both uncross-linked and cross-linked SA films Furthermore, bands between 1600-1615 cm-1 and 1429-1417 cm-1 became more prominent These bands were attributed...
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Mechanisms of polymer ca2+ interaction and their effects on the characteristics of alginate microspheres and films 2
... drug release from S2 and S3 microspheres was found to be comparable with that of SA and S1 microspheres The t75% values of SA and S1 microspheres were 17.1 and 22.9 respectively and 14.3 for 100 ... (c) S2 and (d) S3 microspheres 101 both S2 and S3 microspheres (Table 13) This showed that the matrix of the S2 and S3 microspheres was more permeable to drug release than that of SA and S1 microspheres ... eliminate the adverse effects of in vacuo filtration and oven drying on the structural integrity of the alginate microspheres The M5 and M6 microspheres produced with 0.5 g and 0.8 g of CaCO3 were...
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Mechanisms of polymer ca2+ interaction and their effects on the characteristics of alginate microspheres and films 1
... and FL have similar M/G ratios but significantly different molecular weights This was also observed between MP and NI Comparing the tensile strength of LH and FL films as well as between MP and ... between LH and MP microspheres despite their difference in mean size and extent of cross-linking The same trend was observed between NI and FL microspheres with respect to mean size MA, FL and NI ... change in elastic modulus between MP and NI after cross-linking (Tables and 9) Although the effect of molecular weight on elastic modulus was less obvious between LH and FL, the smaller % difference...
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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx
... the very-KIND-MAP2 interaction J Huang et al Introduction Protein protein interactions play important roles in the molecular recognition and functional modulation between proteins in many signal ... study revealed the structural and functional determinants of the protein protein interaction between v-KIND and MAP2 (i.e the MAP2-binding core module in v-KIND and the v-KIND-binding core module ... residues, and provided evidence that these novel protein protein interaction core modules play a pivotal role in regulating dendrite growth and branching of cerebellar granule cells and hippocampal...
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Báo cáo khoa học: Interaction of the general transcription factor TnrA with the PII-like protein GlnK and glutamine synthetase in Bacillus subtilis potx
... and is a small regulatory protein that belongs to the PII protein family GlnK homologs bind to AmtB and regulate its activity, depending on the cellular nitrogen status [14] Like other GlnK proteins, ... present (B) Effects of various nucleotides (ATP, ADP, AMP, and GTP) and 2-OG at different concentrations on GlnK binding to TnrA GlnK–TnrA interaction in the presence of mm ATP On the other hand, 2-oxoglutarate ... exponential growth phase, and the cells were then washed and resuspended in SMM without nitrate, and finally incubated for a further 20 Samples were taken before and after the shift, and soluble cell-free...
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Báo cáo khoa học: K182G substitution in DevR or C8G mutation in the Dev box impairs protein–DNA interaction and abrogates DevR-mediated gene induction in Mycobacterium tuberculosis doc
... K182G mutant DevR proteins with DevS201P (phosphorylated cytoplasmic domain of DevS) Lane 1, DevSP; lane 2, DevSP and DevR K182G mutant protein; and lane 3, DevSP and WT DevR protein The top ... analysis of protein and DNA (in a half-site of the primary binding motif), we highlight the singular importance of G13– Lys182 and partial importance of A12–Lys182 interaction for DevR binding and function ... that abrogation of interactions mediated by a single amino acid, namely Lys182, with the primary binding site is alone sufficient to abolish specific DNA protein interactions and downstream gene induction...
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Báo cáo khoa học: Alanine screening of the intracellular loops of the human bradykinin B2 receptor – effects on receptor maintenance, G protein activation and internalization pdf
... and B2RwtL For both wild-type cell lines, several bands were detected between 50 and 65 kDa with densities that largely reflected their relative expression levels, and two weaker bands at 42 and ... second and third ICLs (ICL-2 and ICL-3, respectively) of the muscarinic receptor were identified as functionally important for G protein coupling [7,8] ICL-1 and ICL-3 play a role in the interaction ... internalized and surface-bound [3H]BK Protein determination Total protein was quantified with the Micro BCA Protein assay reagent kit from Pierce (Rockford, IL, USA) using BSA as standard Data...
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Báo cáo khoa học: A natural osmolyte trimethylamine N-oxide promotes assembly and bundling of the bacterial cell division protein, FtsZ and counteracts the denaturing effects of urea docx
... area of proteins and the reduction in the solventaccessible surface area produces a decrease in the ligand-binding ability of the protein [52] An unfavorable interaction between protein and osmolyte ... also found to vary from protein to protein [21,22] In addition to their counteracting effects on protein unfolding, osmolytes can affect the functional properties of proteins For example, TMAO ... Where, SN, SI and SU represent the intrinsic signal intensities of the native, intermediate and the unfolded states, respectively DGNfiI and DGIfiU are the standard free energies for the NfiI and IfiU...
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Báo cáo Y học: Interaction between p21-activated protein kinase and Rac during differentiation of HL-60 human promyelocytic leukemia cell induced by all-trans-retinoic acid pdf
... ATRA for 0, 1, 3, and days (lane 0–7) Lane N contained proteins of human neutrophil cytosol (A) and plasma membrane (B) The cytosol (20 lg protein) and solubilized membrane (15 lg protein) were subjected ... at °C, and then protein A–agarose beads were added and gently stirred for h After washing the beads, the immunoprecipitates (150 lg protein) were loaded onto SDS/PAGE and then PAK (A) and Rac ... examined the expression and location of Rac and PAK The interaction between the two proteins during HL-60 myeloid differentiation has received little attention On the other hand, it is well known...
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báo cáo hóa học: " Dexamethasone diminishes the pro-inflammatory and cytotoxic effects of amyloid β-protein in cerebrovascular smooth muscle cells" docx
... forms and fibrils Aβ peptides are proteolytically derived from a large type I integral membrane precursor protein, termed the amyloid β -protein precursor (AβPP) through sequential cleavage by β- and ... fetal bovine serum was obtained from Gibco-BRL (Grand Island, NY) Dexamethasone, ibuprofen, and indomethacin were obtained from Sigma (St Louis, MO) and resuspended as mM stocks in ethanol The Live/Dead ... expression and activation of MMP-2 in response to Dutch mutant Aβ40 (Figure 5) On the other hand, indomethacin and ibuprofen, which did not block HCSM cell death, did not suppress expression and activation...
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báo cáo hóa học: " Pro-inflammatory gene expression and neurotoxic effects of activated microglia are attenuated by absence of CCAAT/enhancer binding protein b" potx
... between LPS and LPS+IFNg effects on C/EBPb and on pro-inflammatory markers in glial cells We have observed that both LPS and LPS +IFNg induce similar increases in C/EBPb mRNA and protein levels ... increases in C/EBPb mRNA and protein induced by LPS and LPS+IFNg were of similar magnitude Differential C/EBPb activation is triggered by LPS and LPS +IFNg Since the mRNA or protein levels of a transcription ... IL-1b, IL-6 and TNFa) and anti-inflammatory (IL-4 and TGFb1) genes in C/EBPb+/+ (white bars) and C/EBPb-/- (black bars) mixed glial cultures Cultures were treated with LPS or LPS+IFNg for h and then...
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Báo cáo khoa học: "Effects of Protein Source and Energy Substrates on the In Vitro Development of Bovine Embryos in a Two-step Culture System" ppsx
... embryos, and to examine the effects of glucose, phosphate and citrate upon the developmental frequency of bovine embryos Materials and Methods In vitr o m a tu ratio n (IVM) Oocyte collection and ... (8.6%), and BSA-FAF (14.3%) Exp Effe c ts of glu co se an d /or ph o sp h ate in th e tw o -ste p c u ltu re s ys te m The effects of glucose and/ or phosphate were examined in Effects of Protein ... glucose and phosphate (16.7%), glucose alone (24.4%), phosphate alone (25.2%), and none (24.4%) 76 Kwang-taek Lim, Byeong-chun Lee, Sung-keun Kang and Woo-suk Hwang Exp Effects of glucose and/ or...
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Báo cáo y học: "A human functional protein interaction network and its application to cancer data analysis" potx
... screen, and had direct interactions with one or more of the proteins in the hand-curated GBM pathway In this way we were able to extend the hand-curated pathway from 73 proteins and 187 interactions ... interactions to 181 proteins and 768 interactions A total of 581 FIs were added between pathway components and new mutated protein interactions (an increase of 148% for proteins and 311% for FIs) ... majority of proteins and interactions in this map: 96% of proteins (70 of 73) and 69% of interactions (129 of 187) The TCGA GBM screen captured 341 mutated genes, including both point mutations and copy...
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Báo cáo y học: "Coverage and error models of protein-protein interaction data by directed graph analysis" pptx
... viable prey and bait Viable prey only Absent Number of proteins TEF2 Systematic bias: per protein and experiment wide The interactions between VBP proteins were tested in both directions, and a surprising ... Yeast two-hybrid systems and protein interaction mapping projects for yeast and worm Yeast 2000, 17:88-94 Schwikowski B, Uetz P, Fields S: A network of protein- protein interactions in yeast Nat ... from Gavin and coworkers [10] An interaction between bait b and prey p is recorded by a dark pixel in (b,p)th position of the matrix (a) Rows and columns are randomly ordered; (b) rows and columns...
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Báo cáo y học: "Consistent dissection of the protein interaction network by combining global and local metrics" ppt
... for protein A and B, respectively (n and m are also called degrees of A and B) A standard model of a protein interaction type network is the fixed-degree-sequence random graph [19] where the interactions ... definition of protein interaction module Intuitively, a protein interaction module is a subnetwork in the protein interaction network with more internal interactions than external interactions ... effective and robust in terms of discovering protein interaction modules in protein interaction networks than either the global or local algorithm by application to the large yeast protein interaction...
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Báo cáo y học: "How complete are current yeast and human protein-interaction networks" pdf
... number of its protein- interaction partners, suggesting that essential human genes can be identified directly from protein- interaction networks (a) For a set of around 31,000 human protein interactions ... creation of two fusion proteins, the ‘bait’ protein fused to a DNA-binding domain and the ‘prey’ protein fused to a transcriptional activator domain An interaction between bait and prey reconstitutes ... and experimental approaches have now mapped a great many yeast and human protein interactions, but how many interactions should we expect? We argue here that the sizes of the complete yeast and...
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Protein turnover in tissues effects of food and hormones
... image features Non-negative matrix factorizations Các bước băm ảnh số Feature Extraction Randomization Quantization Encoding 10 Các bước băm ảnh số Feature Extraction Lấy nét đặc ... cho băm ảnh số Đây bước có nhiều báo, nghiên cứu đề xuất phương pháp để lấy nét đặc trừng ảnh Randomization Trong bước liệu vector lấy từ bước Freature Extraction tạo băm việc sử dụng khóa...
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Interaction of EcoRI with noncognate DNA sequences computational investigation of dynamics of protein water and DNA conformation
... such protein- DNA interactions is how these proteins rapidly identify their target DNA sequences with such Introduction: Protein- DNA Interactions high fidelity The specificity of protein- DNA interactions, ... structural aspect of protein- DNA interactions help to make a more thorough picture of protein- DNA interactions and are described in the next section Introduction: Protein- DNA Interactions Figure ... specificity in EcoRI-DNA interactions and protein- DNA interactions in general [52-55] Since the direct and indirect readout mechanisms have been extensively reviewed by 15 Protein- DNA Interactions: Overview...
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Probing protein dynamics and protein protein interaction by NMR spectroscopy
... HIV-1 Nef protein to form a protein complex (Arold et al 1997) Therefore, to reveal a full picture of protein functions, the static structure alone is not sufficient Protein- protein interactions, ... techniques to study protein structure-function relationship and to reveal proteinprotein interactions Before starting our story, it is necessary to review a general history and basic theories ... of spin interactions LeMaster and Kushlan developed a procedure which labels protein side-chain at alternating carbon positions and randomly fractionally labels 2H, thereby removing the effects...
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