immune dysregulation in allergic disease
Báo cáo y học: "The role of Probiotics in allergic diseases" pptx
... probiotics in allergic disorders The interest in probiotic therapeutic potential in allergic disorders stemmed from the fact that they have been shown to reduce inflammatory cytokines and improve intestinal ... Allergy, Asthma & Clinical Immunology 2009, 5:5 c) The role of probiotics in Allergic Rhinitis Reports on the efficacy of probiotics in treating allergic rhinitis are conflicting Some studies suggest ... 41(Suppi 1):I32-7 Penders J, et al.: Molecular finger printing of the intestinal microbiota of infants in whom atopic eczema was or was not developing Clin Exp Allergy 2006, 36(12):1602-8 Adlerberth...
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Tài liệu Allergic disease and sensitization in Steiner school children pptx
... 19 Kirjavainen PV, Apostolou E, Arvola T, Salminen SJ, Gibson GR, Isolauri E Characterizing the composition of intestinal microflora as a prospective treatment target in infant allergic disease ... missing values Internal nonresponse/missing rates for all children were as follows: maternal smoking during pregnancy (1.7%), current smoking in the household (1.2%), maternal asthma and/or rhinoconjunctivitis ... associations might be the in uence by antibiotics on the intestinal microflora Because the intestinal microflora is a major factor driving the maturation of the immune system in newborns,16 it is plausible...
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Allergic Diseases – Highlights in the Clinic, Mechanisms and Treatment Edited by Celso Pereira docx
... key points of clinical investigation Our understanding of the inflammatory process in allergic disease is clearly defined in many of these chapters, as is the application of science to clinical ... successfully enduring this ordeal yet again In my humble opinion, Allergic diseases - highlights in the clinic, mechanisms and treatment represents a shining example of a productive international ... being investigated, whereas functional proteomic determines constituent proteinprotein, protein-DNA, and protein-RNA interactions and their resulting complexes Proteins are excellent targets in...
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ALLERGIC DISEASES – HIGHLIGHTS IN THE CLINIC, MECHANISMS AND TREATMENT potx
... key points of clinical investigation Our understanding of the inflammatory process in allergic disease is clearly defined in many of these chapters, as is the application of science to clinical ... successfully enduring this ordeal yet again In my humble opinion, Allergic diseases - highlights in the clinic, mechanisms and treatment represents a shining example of a productive international ... being investigated, whereas functional proteomic determines constituent proteinprotein, protein-DNA, and protein-RNA interactions and their resulting complexes Proteins are excellent targets in...
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Báo cáo y học: "Maternal Smoking in Pregnancy: Do the Effects on Innate (Toll-Like Receptor) Function Have Implications for Subsequent Allergic Disease" pps
... smoking is linked to the declining rates of asthma in some developed countries during the same period.12 Although it is unlikely that maternal smoking is the primary causal factor in the changing ... Smoking Has Immunologic Effects on the Developing Fetus There has been growing evidence that subtle increases in immaturity of immune function, particularly Th1 interferon (IFN)-c responses, during ... both explain an increased susceptibility to infection and have implications for subsequent allergen-specific immune development Role of Innate Immunity in Subsequent Immune Development Innate immunity...
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Báo cáo y học: "Nature of Regulatory T Cells in the Context of Allergic Disease." ppsx
... cells in an allergen-specific manner, leading to a reduction in allergic inflammation.43–45 Blocking antibodies also inhibit IgE-facilitated allergen presentation to T cells and prevent allergen-induced ... Ying S, Varney VA, et al Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells expressing ... Arvidsson M, et al Basophil interleukin and interleukin 13 production is suppressed during the early phase of rush immunotherapy Int Arch Allergy Immunol 2006;141:346– 53 21 Eberlein-Konig B, Ullmann...
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Báo cáo khoa hoc:" Wnt expression is not correlated with β-catenin dysregulation in Dupuytren''''s Disease" doc
... dual kinase mechanism involving CKI (casein kinase-1) and GSK-3β (glycogen synthase kinase-3β) [30-32] CKI, which is recruited to the destruction complex by the axin binding protein diversin [33], ... variable in this fibroproliferative disease with the only consistent finding being down-regulated Wnt 11 mRNA expression in disease tissue As Wnt11 signalling is independent of β-catenin and no ... Wnt 11 D2 Pooled W D D2 E M H2 L R T W Control Control Control Disease Disease Disease Disease Disease Disease Disease Disease Disease 5/37 4/17 1/3 0/28 1/4 0/16 0/9 0/16 0/2 2/9 5/22 11/19...
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Báo cáo y học: "Does CD4+CD25+foxp3+ cell (Treg) and IL-10 profile determine susceptibility to immune reconstitution inflammatory syndrome (IRIS) in HIV disease" pdf
... 2-phase increase in CD4 T-cells occurs after initiating HAART; a rapid initial increase in memory T cells in the first few months, followed by a steady rise in naive T-cells that continue for ... be either tested in a disease- specific approach (i.e examining the role of Tregs in TB-IRIS subjects) or by examining all forms of IRIS (both infectious and non-infectious) In addition, the role ... regulation of immune responses to helminths but also cause allergic pathologies [47,49] IL-4 and IL-13 are implicated in inhibiting the generation of proinflammatory cytokines by macrophages [49] In addition...
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Báo cáo y học: "Urokinase-type plasminogen activator and arthritis progression: role in systemic disease with immune complex involvemen" doc
... models are induced using an intra-articular injection resulting in monoarticular arthritis in the injected joint In these monoarticular models, the enhanced disease severity seen in u-PA-/mice ... albumin (ovalbumin, 20 mg/kg body weight; Sigma) was injected intravenously followed by intraperitoneal injection of ml rabbit polyclonal IgG rich in antibody to chicken egg albumin (anti-ovalbumin, ... [3] Several different cell types present in arthritic joints can produce PAs and their inhibitors in vitro, including in response to inflammatory cytokines [4-11] We and other workers have previously...
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Báo cáo y học: "Human metapneumovirus induces more severe disease and stronger innate immune response in BALB/c mice as compared with respiratory syncytial virus" pps
... Immunohistochemical staining for HMPV Groups of intraalveolar macrophages and pneumocytes expressing HMPV antigens (A to D): hematoxylin-eosin staining, original magnification × 20; D: immunostaining with ... 4% buffered formalin Paraffinembedded tissue blocks were cut at μm Deparaffinized sections were evaluated following hematoxylin & eosin (H&E) staining or by immunolabelling using anti-HMPV rabbit ... intraperitoneal injection of ketamine (2 mg/mouse) and xylazine (0.15 mg/mouse), and infected intranasally (i.n.) with × 105 PFU HMPV strain D03-574 or × 105(when indicated 106) PFU RSV strain...
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Báo cáo y học: " Th2 cytokines and asthma The role of interleukin-5 in allergic eosinophilic disease" doc
... autophosphorylation Like interleukin-3 and GM-CSF, interleukin-5 induces rapid tyrosine phosphorylation of several proteins, further indicating that tyrosine kinases are involved in the cellular activation ... the interleukin-5-induced hyperreactivity was abated by blocking the activity of interleukin-1, and interleukin-1β mRNA and protein levels are increased by interleukin-5 Interleukin-5 may contribute ... production of interleukin-5 may contribute to the chronicity of inflammation [41,42] The interleukin-5 receptor is in the type I cytokine family, which includes receptors for interleukin-2 through interleukin-7,...
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A double blind randomized placebo controlled clinical trial on the supplementation of probiotics in the first six months of life in asian infants at risk of allergic diseases effe
... in the Indian Sub-Continent to 12.7% in Latin America in the 6-7 year olds Co-morbidity with asthma and eczema varied from 1.6% in the Indian sub-continent to 4.7% in North America [22] In Singapore, ... years of life in Asian infants at risk of allergic disease However, probiotics may enhance specific antibody responses in infants receiving certain Hepatitis B vaccine schedules Despite increase hospitalization ... in Asian infants at risk of allergic disease ii specific antibody response against Hepatitis B as a surrogate marker for infant immune response to vaccination iii protective benefit against infections...
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The study of gene and protein vaccines for allergic diseases in mice
... studies indicated that CD4 T lymphocytes were the primary responding cells in these assays These responses were maintained in vaccines for at least a year (longest time point tested), indicating ... signaling pathway IL4 binds the IL-4 receptor α-chain (IL-4Rα) that is contained in both IL-13R and IL-4R IL-13R has a unique IL-13-binding chain (IL-13Rα1 or IL-13Rα2) IL-4R also contains the ... experimental model of allergic asthma that closely resembled human asthma is important as they contribute in gaining insights into the pathogenesis of allergy and in defining the potential strategies...
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Association studies of genetic polymorphisms found in interleukins 12, 13 and CD14 gene with asthma and allergic diseases
... background staining, the agarose gel is de-stained by soaking in de-ionized water for 10 minutes 3.7 Sequencing for polymorphisms Chain termination sequencing was employed This method involves the ... certain medications, in particular antihistamines, inhibit SPT responses by interfering with mast cell and histamine responses 20 2.11 Reason and aims of doing this study Owing to preceding studies ... of INFγ and both cytokines are essential in the induction of a protective Th-1 immune response to intracellular pathogens, with INFγ down regulating the production of IgE [46, 47] The Th-1 inducing...
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Báo cáo y học: "BRCA1 May Modulate Neuronal Cell Cycle Re-Entry in Alzheimer Disease"
... resulting in cell death These findings raise the possibility that BRCA1 accumulates in neurons early in the disease and only in those cases in the early stages of AD and may or may not be independent ... implicated to play a role in maintaining genomic integrity in mitochondria and in the nucleus [40] Recent work has related these functions specifically to telomere maintenance In BRCA1 -/- cells, telomere ... fixed either in 10% buffered formalin or in methacarn (methanol:chloroform:acetic acid, 6:3:1), and embedded in paraffin 6μm sections were deparaffinized in xylene and rehydrated in graded alcohol,...
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Tài liệu Báo cáo khoa học: The small heat shock proteins and their role in human disease pptx
... formation of huntingtin-containing inclusion bodies in Huntington’s disease encourages cell survival, whereas monomers and small inclusion bodies of huntingtin, a protein possessing abnormal polyQ ... aA-crystallin R116 and both are conserved a-crystallin domain arginines R120G aB-crystallin permits intermediate filament self association in vitro, although binding of the modified protein to filaments increases ... coexpression, indicating R120G aB-crystallin is chaperoned R120G aB-crystallin is disorganized and aggresome-like inclusions develop in cultured nonmuscle cells deficient in desmin, again demonstrating inclusion...
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Control of Innate and Adaptive Immune Responses during Infectious Diseases ppt
... Hospital, Cincinnati, OH, USA; Division of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH, USA george.deepe@uc.edu Katherine N Gibson-Corley Department of Veterinary ... Control of Innate and Adaptive Immune Responses during Infectious Diseases Julio Aliberti Editor Control of Innate and Adaptive Immune Responses during Infectious Diseases Editor Julio ... protection after infection Obviating the predominant role of TLR’s in initiating innate IL-12 production in the presence of parasite derived molecules TLR2 has been found to be involved in the development...
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Báo cáo khoa học: Alternative splicing: role of pseudoexons in human disease and potential therapeutic strategies pot
... 5¢ss recognition in the normal splicing process [55] First, U1snRNP binding to an intronic splicing processing element has been found to inhibit pathological pseudoexon inclusion in intron 20 of ... splicesupporting intronic mutation in the last bp position of a cryptic exon within intron of the CYBB gene induces its incorporation into the mRNA causing chronic granulomatous disease (CGD) ... many of the ‘new’ exons in our genome originate from the insertion of transposable sequence elements belonging to the SINE and LINE classes in the eukaryotic genome [23–25] In particular, exonization...
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EDUCATING TO IMPROVE POPULATION HEALTH OUTCOMES IN CHRONIC DISEASE ppt
... nutrition etc Smoking Individual – Brief interventions in each consultation Community – Smoke free zones in public buildings • Conducting education to school kids about smoking • Running smoking education ... chronic disease They are relevant to every patient, community or interaction These domains were developed by combining the existing domains of the various health disciplines listed on page 14 They include: ... multidisciplinary teamwork, maintaining medical records; confidentiality; ethics in managing chronic disease; duty of care; professional standards, self-care, disciplinary scope of practice Clinical...
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Báo cáo khoa học: Nature, nurture and neurology: gene–environment interactions in neurodegenerative disease docx
... made in identifying genetic factors contributing to PD in recent years [135] Low concordance for clinical disease in monozygotic twins indicates environmental in uences on PD [136], and the finding ... Gene–environment interactions in neurodegenerative disease Table Environmental in uences on neurodegenerative disease AD, Alzheimer’s disease; HD, Huntington’s disease; PD, Parkinson’s disease Disease ... neurodegenerative diseases caused by CAG repeat expansions, encoding polyglutamine tracts in different proteins, suggesting that these diseases may involve overlapping molecular mechanisms of pathogenesis involving...
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