everybody in your company is responsible for selling not just your direct sales team
Báo cáo khoa học: A novel factor XI missense mutation (Val371Ile) in the activation loop is responsible for a case of mild type II factor XI deficiency doc
... valine This conserved amino acid is replaced by isoleucine in the Val371Ile FXI mutant Interestingly, an isoleucine residue naturally occupies the position corresponding to FXI Val371 in some ... in this position most likely causes some degree of structural change; this is especially true in the case of the introduction of an isoleucine, a b-branched amino acid that is not exible In the ... were performed in NaCl Tris supplemented with 0.3% BSA at room temperature; all other incubations were done in NaCl Tris containing 5% milk Proteins were detected using Enhanced Chemioluminescence,...
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Báo cáo khoa học: PSI1 is responsible for the stearic acid enrichment that is characteristic of phosphatidylinositol in yeast pdf
... composition of this phospholipid is quite distinctive in living organisms because, in comparison with other phospholipids, PI is by far the most saturated In bovine heart, bovine liver and rat ... among the proteins identified in proteomic studies of S cerevisiae mitochondria [31,32] Psi1p is involved in PI remodeling As noted in the Introduction, at least two models can explain the specific ... novo synthesis of this lipid (i.e the second hypothesis) According to this hypothesis, previously raised for mammals [34–36], the decrease in the percentage of stearic acid into PI in psi1D cells...
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Báo cáo y học: " JNK activation is responsible for mucus overproduction in smoke inhalation injury" potx
... Since smoke inhalation during fires is associated with mucus hypersecretion, we evaluated mucin secretion in the airway of mice by using the PAS stain The PAS stain is mainly used for staining ... Bennett B, Karin M, Yang L, Manning AM, Firestein GS: c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis J Clin Invest 2001, 108(1):73-81 ... for data analysis, and for drafted this manuscript; KYK was responsible for the analysis and design for the histologic study; OS oversaw the animal experiments, instructed WIC in his implementation;...
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Báo cáo khoa học: A characteristic Glu17 residue of pig carnitine palmitoyltransferase 1 is responsible for the low Km for carnitine and the low sensitivity to malonyl-CoA inhibition of the enzyme docx
... N-terminal and C-terminal regions of CPT1A [9] In this model, Asp17 does not face the C-terminal fragment A possible explanation for this is that, in the case of CPT1B, the docking of the N-terminal ... product in which an EcoRI site (in bold in the forward primer sequence) was introduced just before the ATG codon (underlined in the forward primer sequence) This PCR product was cloned in pGEMT, ... product, in which an EcoRI site (in bold in the forward primer sequence) was introduced just before the ATG codon (underlined in the forward primer sequence), and a point mutation was introduced...
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Báo cáo khoa học: Direct CIII–HflB interaction is responsible for the inhibition of the HflB (FtsH)-mediated proteolysis of Escherichia coli r32 by kCIII docx
... chaperone machine in vivo [18–20] However, this proteolysis is much slower in vitro, because of a lack of chaperone machinery The in vitro proteolysis requires ATP [14] We examined the proteolysis of ... r32 did not co-elute with CIII, implying that r32 does not interact with CIII Discussion Phage protein CIII works as an antiprotease against E coli HflB and protects kCII by directly binding to ... substrates The relative binding affinity for r32–HflB interaction and CIII–HflB interaction would play an important role in the inhibition of proteolysis of r32 by HflB Interestingly, both CII and r32...
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Báo cáo khoa học: Redox reaction between amino-(3,4-dihydroxyphenyl)methyl phosphonic acid and dopaquinone is responsible for the apparent inhibitory effect on tyrosinase doc
... reactions in solution What distinguishes our case from other redox 4104 B Gasowska et al (Eur J Biochem 269) ˛ interactions in this system is the decomposition of the phosphonic o-quinone This decomposition ... 362–367 Espin, J.C & Wichers, H.J (1999) Slow-binding inhibition of mushroom (Agaricus bisporus) tyrosinase isoforms by tropolone J Agric Food Chem 47, 2638–2644 Kahn, V & Andrawis, A (1985) Inhibition ... (cyclization of dopaquinone and decomposition of the phosphonic o-quinone) the values obtained are not very precise (150 mV for Dopa and 195 mV for compound 1), but indicate that the formation of the...
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báo cáo hóa học:" Activation of PKA, p38 MAPK and ERK1/2 by gonadotropins in cumulus cells is critical for induction of EGF-like factor and TACE/ ADAM17 gene expression during in vitro maturation of porcine COCs" doc
... revisited: binding of GATA, cyclic adenosine 3', 5'-monophosphate response element-binding protein and activation protein (AP)-1 proteins to a distal novel cluster of Page of (page number not for ... necrosis factor α converting enzyme/a disinteglin and metalloptotease 17; Has2: hyaluronan synhase 2; Tnfaip6; tumor necrosis factor αinduced protein 6; Ptx3: pentraxin 3; PGE2: prostagrandin E2; ... amplified for X cycles (Table 1) of denaturation at 94°C for 30 sec, primer annealing at Y°C (Table 1) for min, and extension at 68°C for min, with a final extension step of at 68°C β-actin was...
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Báo cáo sinh học: "Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance" ppt
... IGFBP-7 for insulin [6] Interestingly, Imp-L2 has been shown to bind human insulin, IGF-I, IGF-II and proinsulin, and its homolog in the moth Spodoptera frugiperda, Sf-IBP, can inhibit insulin signaling ... with insulin for binding to the insulin receptor (InR) and inhibit the autophosphorylation of InR [6] Furthermore, IGFBP-7 is suspected to be a tumor suppressor in a variety of human organs, including ... Results Insulin/insulin-like growth factor (IGF) signaling (termed IIS) is involved in the regulation of growth, metabolism, reproduction and longevity in mammals [1-3] The activity of IIS is regulated...
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Genetic approaches to study liver development in zebrafish core component sec13 in COPII complex is essential for liver development in zebrafish
... used in performing forward genetic screening The intrauterine development of mouse fetus is inconvenient for the observation of phenotypes in embryonic stages In addition, liver is the initial ... essential functions, including storage of substances, maintaining homeostasis, blood detoxification, producing numerous enzymes for metabolism, and serving as an endocrine/exocrine organ In mammalian ... with rhodamine-labeled phalloidin to visualize surrounding tissues The liver is marked by an arrowhead; the intestinal bulb primordium is outlined in white Dorsal is to the top, and left is to the...
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Tài liệu Báo cáo Y học: Interallelic recombination is probably responsible for the occurrence of a new as1-casein variant found in the goat species potx
... 30 s (or min) at 94 °C, annealing for 30 s (or min) at 47–60 °C, and extension for 30–60 s (or min) at 72 °C, Fig Disc-PAGE at pH 8.6 of individual whole caprine casein samples containing different ... allele, which is deleted in the F allele, is mutated to T in the M allele, giving rise to a Ser fi Leu substitution Analysis of the intronic flanking sequences The flanking intronic regions directly ... and M, which is lacking in the A allele, giving a total of 25 polymorphic sites useful for phylogenetic allele comparisons Taking into account these data, it is worth noting that in the 5¢ part...
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DO YOU FACE THESE CULTURE CHALLENGES IN YOUR COMPANY OR TEAM?by Richard Parkes Cordock SMASHWORDS EDITIONCopyright © Richard Parkes Cordock 2012 First Published 2012 by ELW Publishing Bath, UKThank you for downloading this free ebook. You are welcome potx
... to thinking like a business owner You know that your actions and decisions have a direct impact on your customers' experience But not everybody in your company thinks this way Not everybody is ... what is understood and believed in the wider workforce You may recognise this gap in your company too This 'disconnect' can be a major barrier to achieving your company' s goals Example 1: Tom is ... George has his entire team in one building, it is easy for him to use Enterprise LEADER as a catalyst for change and a vehicle to better engage his workforce He gets his high performing superstars...
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Báo cáo khoa học: " Cap-independent protein translation is initially responsible for 4-(N-methylnitrosamino)-1-(3-pyridyl)-butanone (NNK)-induced apoptosis in normal human bronchial pithelial cells" pot
... Our findings of rapamycininduced caspase activation is coincident with Nottingham et al’s [28] result that rapamycin expressed activated caspase in spinal cord of rats Rapamycin-dependent increase ... to date, being responsible for the cleavage of a large number of target proteins [23,24,26,27] Rapamycin forms a complex with immunophilin protein FKBP (FK506-binding protein), which binds to FRAP, ... of FRAP in cells is potently inhibited by rapamycin [11] Rapamycin inhibits cap-dependent, but not cap-independent translation [2,17] In this study, we hypothesized that state of protein translation...
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Báo cáo y học: "Is disturbed clearance of apoptotic keratinocytes responsible for UVB-induced inflammatory skin lesions in systemic lupus erythematosus" ppsx
... staining), 10 mM citrate pH 6.0 (CD68 staining), or 10 mM Tris, mM EDTA pH 9.0 (CD3 staining) After washing in PBS, endogenous peroxidase was blocked by incubation in 0.37% H202 in PBS for 30 minutes ... biopsy showing CD68 staining combined with haematoxylin staining using diaminobenzidine (DAB) for visualisation of CD68-positive cells Magnification, ×400 Two macrophages that contain multiple ... lesions coincided with the presence of two or more SBCs in the epidermal layer lying over the infiltrate Scoring was performed by two independent observers not informed about the clinical findings...
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Báo cáo y học: "Is disturbed clearance of apoptotic keratinocytes responsible for UVB-induced inflammatory skin lesions in systemic lupus erythematosus" pot
... apoptosis in FLS even in the presence of a dominant-negative p53 Discussion Several therapeutic approaches to RA have focused on inducing apoptosis in the synovium, especially the intimal lining ... expression in cultured FLS A representative time course and dose response are shown in Figure p53-independent apoptosis induced by PUMA To determine whether p53 is required for PUMA-induced apoptosis, ... transfection with PUMA cDNA Apoptosis was induced in FLS despite expression of the dominant-negative protein *p < 0.05, n = also be distinguished from other cells in that p53 is expressed constitutively...
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Báo cáo y học: "Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes" pptx
... specific inhibition of ADAMTS5 is chondroprotective for articular joints [41, 42] Interestingly, we did not observe a significant induction of ADAMTS4 upon FGF-2 stimulation This finding suggests ... axis (unpublished data) It is possible that BMP-7 augments its anabolic activity, in part, via induction of FGFR3, thus indirectly potentiating endogenous FGF18FGFR3 signaling This may explain ... level in OA because chondrocyte catabolism predominates over anabolism resulting in net cartilage degeneration Elevated levels of pro-inflammatory cytokines, inflammatory mediators and certain growth...
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Đề tài:what qualities and skill are needs for the manage people in a company? what is the importance of good human resources?
... practices 7)Information processing and thinking capacity • The power of your brain is incalculably large The manager have an enormous potential for creativity, innovation and invention They knowing how ... control your thoughts • • • • • • · having a good memory, good concentration and a good imagination · knowing how to think more creatively · knowing how to use brainstorming in a group setting · ... are talking to • 4.Take into account that you can be wrong • 5.Leave the space for others to think • 6.Timing is the key • 7.What you send is what you get • 8.What kind of rules you can think out...
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Marketing Strategy for welding and cutting products in Namviet company.doc
... still find the direction its business and established in sensitive to this point is a great effort, the results of the search reasonable business directions, finding a nick market to business in ... Le Minh Marketing Strategy for welding and cutting products in Namviet company and year Task of Administrative Department: in charge all issues of administrative human, labor salary policy, internal ... Company Unitech This is a company specializing in mechanical cutting including welding industry, high-capacity consultant, sales team and technicians crowded, agency official airline of Finland Kemppi...
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In order to become competent in a foreign language, it is important for language learners not only to acquire new vocabularies and a new set of phonological and syntactic rules but also to learn what Wilson (1986)
... Phước, Tây Ninh thành phố Hồ Chí Minh; ĐBSCL gồm tỉnh Long An, Tiền Giang, An -18- Giang, Kiên Giang, Cà Mau, Sóc Trăng, Bạc Liêu, Đồng Tháp, Bến Tre, Hậu Giang, Vónh Long, Trà Vinh thành phố ... lớn, nước ròng… Nam Bộ vùng đất đa dạng sinh học Khí hậu - thuỷ văn tạo điều kiện cho động thực vật sinh sôi nảy nở, thích hợp cho việc phát triển nguồn sinh vật cạn nước, thuận lợi cho canh tác ... lớn nước Ven biển có rừng ngập mặn rộng lớn Từ Cà Mau đến Kiên Giang có rừng nguyên sinh U Minh Thượng, U Minh Hạ Rừng có nhiều loài động thực vật quý Hình ảnh quen thuộc sân chim, kèo ong, sếu...
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Tài liệu Investigation of Organic Chemicals Potentially Responsible for Mortality and Intersex in Fish of the North Fork of the Shenandoah River, Virginia, during Spring of 2007 ppt
... biodiversity Fish kills and observations of intersex in fish have been increasing in regularity in the Shenandoah River and Potomac River basins in Virginia (Blazer and others, 2007) The fish kills ... streamflow-gaging station 1633000 Sampling Processing and Chemical Analysis Each POCIS and SPMD was extracted individually before designating extracts for specific processing and analysis procedures ... SPMDs not containing PRCs in each canister was screened for estrogenic chemicals by the YES assay and the remaining SPMD was held in reserve Agricultural Pesticides Details for the processing and...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ mở máy động cơ lồng sóc đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008