... reliable in their efforts to provide information that is complete and generally in accord with the standards accepted at the time of publication However, in view ofthe possibility of human error ... of diagnosis, and initial management strategies In preparing the manuscript, we were struck by several insights First was the importance of general supportive care ofthe patient regardless of ... ESSENTIALS of CRITICAL CARE Edited by Darryl Y Sue, MD Professor of Clinical Medicine David Geffen School of Medicine at UCLA Division of Respiratory and Critical Care Physiology and Medicine,...
... Ministry of Health, Rome); Netherlands (Netherlands Centre for Monitoring of Adverse Reactions to Drugs); Sweden (the Medical Products Agency); Switzerland (Intercantonal Office for the Control of ... upon the patients’ complaint of ‘persistent dry cough’ The character ofthe clinical complaint and its nature can be lost, andthe data corrupted at source, by the careless use of words other ... edited and prepared for publication the working-group reports andthe text ofthe present publication; and Kathryn Chalaby-Amsler and Christine Dubendorfer provided the essential administrative and...
... consultation with the women’s health community and include the principle ofthe right to be warned and informed expands regional reporting centres and adequately funds these as the front lines ofthe reporting ... in the Health Products and Foods Branch to replace the Therapeutic Products Programme: the Therapeutic Products Directorate (TPD); the Biologics and Genetic Therapies Directorate (BGTD); andthe ... health, sex and gender.10 The modern women’s health movement grew out of a feminist critique during the 1960s ofthe medical industry as an institution of social control over women andthe demands for...
... rệt tiêu vân so với fenofibrat [nguy tơng đối = 10,84 (8,44 13,95)] Tiêu vân gemfibrozil thờng gặp trờng hợp phối hợp với cerivastatin (Lipobay) báo cáo với fenofibrat (theo Am J Card.; 94: 935-938; ... dụng amiodaron (theo Reactions Weekly; Số 1022; 09/10/2004) Liệu pháp insulin làm tăng nguy ung th đại trực tràng (Hoa Kỳ) Nghiên cứu hồi cứu 24.918 bệnh nhân tiểu đờng týp 2, theo dõi thời gian ... (1,07-2,48) so sánh với nhóm ngời dùng thuốc kháng H2 từ lâu (theo JAMA, 292; 1955 - 1960; Số 16; 27/10/2004) Gemfibrozil gây phản ứng có hại nhiều fenofibrat (Hoa Kỳ) Kiểm tra lại báo cáo phản ứng có hại...
... thận trọng theo cách uống trên, uống muối sắt, tetracyclin khác, corticoid, muối lithi, thuốc chống viêm không steroid, alendronat v.v (Theo J.national cancer Jnit 95; số 13; 7/2003) (Theo Reactions ... Khuyến cáo thầy thuốc nên ý đến trờng hợp nghi ngờ phản ứng phản vệ thận trọng trớc gây mê (Theo Anesthesialogy: 99; số 3; 9/2003) 85 ... chứa nguyên tố vi lợng kẽm nguồn (32%) kèm ăn thịt bê (11%) ngũ cốc (5%) Trong số 587.440 ngời/năm theo dõi, có gặp 2.902 trờng hợp bị ung th tuyến tiền liệt Loại trừ yếu tố nguy khác, thấy số bổ...
... days to weeks after initiation of therapy Many drugs of common use are associated with a 1–2% rate of "rashes" during premarketing clinical trials The risk is often higher when medications are ... but neither their incidence nor their impact on public health has been evaluated In a series of 48,005 inpatients over a 20-year period, morbilliform rash (91%) and urticaria (6%) were the most ... receive about 120 million courses of drug therapy, and half of adult Americans receive prescription drugs on a regular outpatient basis Many additional patients use over -the- counter medicines that may...
... many ofthe medications that are frequently a cause of drug eruptions Both CD4 and CD8 clones were often obtained, whatever the clinical type of eruption Some clones produced a TH0 profile of cytokines ... sulfamethoxazole presented either in covalent or noncovalent bound form, but the former was the exception andthe latter the rule Since the noncovalent binding is reminiscent ofthe pharmacologic interaction ... drug and its receptor, the denomination of pharmoco-immune (p-i) concept has been proposed Once a drug has induced an immune response, the final phenotype ofthe reaction probably depends on the...
... neutrophils or eosinophils and from the intensity of stimulation and response GENETIC FACTORS AND CUTANEOUS DRUG REACTIONS Specific genetically determined defects in the ability of an individual to ... Minocycline and thiazide diuretics may exacerbate subacute systemic lupus erythematosus, and pemphigus can be induced by D-penicillamine, captopril, and other ACE inhibitors The hypothesis that ... cytotoxic T cells have been detected in the skin lesions of fixed drug eruptions andof TEN In TEN, blisters that result from accumulation of interstitial fluid under the necrotic epidermis contain T...
... (transversal depression ofthe nail plate), onycholysis (detachment ofthe distal part ofthe nail plate), onychomadesis (detachment ofthe proximal part ofthe nail plate), pigmentation, and paronychia ... slow-healing eschar formation Development ofthe syndrome is unrelated to drug dose, andthe course is not altered by discontinuation ofthe drug after onset ofthe eruption Warfarin reactions are ... after discontinuation ofthe responsible agent The prevalence and severity of alopecia depend on the drug as well as on individual predisposition A considerable number of drugs have been reported...
... eruptions are the most common of all druginduced reactions, often start on the trunk or areas of pressure or trauma, and consist of erythematous macules and papules that are frequently symmetric and may ... mild and nonspecific changes A viral exanthem is the principal differential diagnostic consideration, especially in children Absence of enanthems, absence of symptoms in ears, nose, and throat and ... respiratory tract, and polymorphism ofthe skin lesions support a drug rather than a viral eruption Maculopapular reactions usually develop within week of initiation of therapy and last less than...
... involve other organs, including the liver, kidney, brain, and joints Drugs are an infrequent cause of vasculitis Infection and collagen vascular disease are responsible for the majority of cases ... and shows scattered pustules in the upper part ofthe epidermis instead ofthe full-thickness necrosis that characterizes TEN Fever is present with elevated neutrophil counts, and sepsis is often ... sulfonamides, other antimicrobials, and several NSAIDs The presence of eosinophils in the perivascular infiltrate of skin biopsy may indicate a higher probability of a drug etiology PUSTULAR ERUPTIONS...
... rechallenge) and signs of delayed hypersensitivity (rash, late onset, hepatitis) The risk is lower in patients of African ancestry and strongly correlated with HLAB*5701 Penicillin The utilization rate of ... eventually ensues whenever NSAIDs are subsequently ingested Proof ofthe association of symptoms and NSAID use requires either clear-cut history of symptoms following drug ingestion or an oral challenge ... phenobarbital, phenytoin, and carbamazepine among the older anticonvulsants, and lamotrigine among the newer, are associated with many types of severe reactions and a high incidence of less severe reactions,...
... white lines, and pigmentation Sterile cellulitis and phlebitis and ulceration of pressure areas occur with many of these agents Also reported is acral erythema, which begins with dysesthesia followed ... hair, mucous membranes, and appendages, are sensitive to their effects As a result, stomatitis and alopecia are among the most frequent dose-dependent side effects of chemotherapy Various nail abnormalities ... hypotension, and, in rare cases, cardiac arrest Agents Used in Cancer Chemotherapy Since many agents used in cancer chemotherapy inhibit cell division, rapidly proliferating elements ofthe skin,...
... responsible for the study concept and design andthe acquisition of data, and supervised the study US and AI drafted the manuscript, and US, AI and DC were responsible for critical revision ofthe manuscript ... unknown It has been assumed that the lipid solubility of these compounds alters the physicochemical properties ofthe cell membrane and thus impairs the activities ofthe membrane receptor systems ... which may explain the remarkable effects of levodopa in these two cases The effects of general anaesthesia were for many years attributed to changes in the physical chemistry of neurons More recently,...
... mụn mủ toàn thân cấp tính (acute generalized exanthematous pustulosis), -Phát ban thuốc cố định (fixed drug eruption), -Hồng ban đa dạng (erythema multiforme), hội chứng Stevens-Johnson, ly thượng...
... kèm theo sốt thường găp Các bệnh nhân có nhiều giai đoạn FDE, thường gặp tăng sắc tố vị trí tổn thương có lúc trước 1.4 Phân loại hồng ban đa dạng (EM) tranh luận (controversial) chút mơ hồ Theo ... ứng Tuy nhiên, phát triển pemphigus thuốc xác định phần yếu tố di truyền 1.6 Pemphigoid thuốc theo sau thuốc dùng đường uống thoa +Ngứa triệu chứng thường gặp Bệnh cảnh viêm nắp quản (epiglottis)...
... lesion): +Các tổn thương khởi phát dát hồng ban hình vòng có bờ rõ ràng nhô cao Màu sắc thay đổi tùy theo vị trí, vùng trung tâm tổn thương sậm màu, đậm màu (dusky), tím; vùng ngoại biên có vành đai ... nước bóng nước +Các tổn thương “hình bia” “đồng tử”này thường gặp EM minor nhiễm trùng tiến triển theo kiểu hướng tâm (centripetal), +Các tổn thương rộng, hình dạng không đều, hợp thành nhóm thấy...