... intestinal peptide (VIP) receptor-binding activity (A) and adenylatecyclase activation (B) with VIP and pituitaryadenylate cyclase- activatingpolypeptide 27 (PACAP27) in L2 cells (A) Concentration-inhibition ... Pituitaryadenylate cyclase- activatingpolypeptide and its receptors: from structure to functions Pharmacol Rev 52, 269–324 10 Onoue, S., Endo, K., Yajima, T & Kashimoto, K (2002) Pituitaryadenylate ... & Mutt, V (1970) Polypeptide with broad biological activity: isolation from the small intestine Science 169, 1217–1218 Arimura, A (1992) Pituitaryadenylatecyclaseactivatingpolypeptide (PACAP):...
... & Mutt V (1970) Polypeptide with broad biological activity: isolation from the small intestine Science 169, 1217–1218 14 Arimura A (1992) Pituitaryadenylatecyclaseactivatingpolypeptide (PACAP): ... Acad Sci USA 95, 13363–13383 10 Onoue S, Endo K, Yajima T & Kashimoto K (2002) Pituitaryadenylate cyclase- activatingpolypeptide and vasoactive intestinal peptide attenuate glutamateinduced nNOS ... attenuated by neuropeptides, including vasoactive intestinal peptide (VIP) [13] and pituitaryadenylate cyclase- activatingpolypeptide (PACAP) [14–16], and their neuroprotective effects were associated...
... similar studies of ATP ⁄ GTP substrate preference in mammalian adenylate and guanylate cyclases Whereas point mutations converted a guanylate cyclase protein to an AC, the reverse was not achieved Therefore, ... Kanacher T, Schultz A, Linder JU & Schultz JE (2002) A GAF-domain-regulated adenylyl cyclase from Anabaena is a self -activating cAMP switch EMBO J 21, 3672–3680 Bruder S, Linder JU, Martinez SE, Zheng ... domain J Biol Chem 280, 3771– 3779 16 Salomon Y, Londos C & Rodbell M (1974) A highly sensitive adenylatecyclase assay Anal Biochem 58, 541–548 FEBS Journal 274 (2007) 1514–1523 ª 2007 The Authors...
... Genes and Proteins: MorA Motility regulator PpAC Pseudomonas putida Adenylatecyclase AC AdenylateCyclase DGC Diguanylate Cyclase PDE Phosphodiesterase xi CHAPTER INTRODUCTION Bacteria can exist ... 3.19c Cladogram of PpAC and Adenylate cyclases from other bacterial species generated using Clustal W and Tree View……………………………… 3y FIG 3.19d Phylogram of PpAC and Adenylate cyclases from other bacterial ... the Pfl_5493 (Adenylate cyclase) locus and flanking genes in P.fluorescens PfO-1 The primers are depicted as arrows The primer design and cloning strategy to clone the Adenylatecyclase homolog...
... with an IV load (125) The most important incretin hormones are glucose dependent insulinotropic polypeptide (GIP) and glucagon like peptide (GLP)-1 (126) GIP is secreted by K-cells located in ... 115–23 132 Kieffer TJ, CH McIntosh, and RA Pederson, Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide in vitro and in vivo by dipeptidyl peptidase IV...
... …….107 4.1 Studies Using Bacterially Produced Polypeptides……………………………………… 108 4.1.1 The design and production of polypeptides………………….108 4.1.2 The polypeptide- containing complexes… ………………….111 ... Results………………………… ………66 3.1 Studies Using Bacterially Produced Polypeptides…………………………………………67 3.1.1 Description of the Recombinant Cationic Polypeptides….… 67 3.1.2 Activation of TrkA, Erk and Akt ... Methods………… …………… …….50 2.1 Studies Using Bacterially Produced Polypeptides…………………………………………51 2.1.1 Plasmid Construction.……… ………………………….………51 2.1.2 Polypeptide Expression, Purification and Detection.………...