NBS1 deficiency promotes genome instability by affecting DNA damage signaling pathway and impairing telomere integrity
Tài liệu Báo cáo khoa học: Pyruvate reduces DNA damage during hypoxia and after reoxygenation in hepatocellular carcinoma cells pptx
... hypoxia and reoxygenation have been reported to induce DNA damage [30–32], we examined the effects of pyruvate addition during hypoxia and after reoxygenation on DNA damage HepG2 cells were incubated ... by Singh et al [48], using alkaline electrophoresis, which allows detection of single-strand and double-strand breaks Pyruvate reduces DNA damage during ⁄ after hypoxia Cells cultivated in Petri ... new insights into the role of pyruvate in tumor cells during hypoxia We show here that tumor HepG2 cells are inclined to maintain extracellular pyruvate at a constant level (0.4 mm) Hypoxia inhibits...
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Tài liệu Báo cáo khoa học: Role of transcription factor activator protein 1 (AP1) in epidermal growth factor-mediated protection against apoptosis induced by a DNA-damaging agent doc
... ⁄ Akt signaling was not necessary for EGFinduced protection of TMK -1 cells against apoptosis Role of AP1 in EGF-mediated cell protection A B C MAP kinase signaling provides an alternative pathway ... induced by DNA-damaging agents Oncogene 17 , 13 1 14 1 15 Geier A, Beery R, Haimsohn M, Hemi R, Malik Z & Karasik A (19 94) Epidermal growth factor, phorbol esters, and aurintricarboxylic acid are survival ... the MAP kinase cascade [49] Our study showed that EGF caused a substantial increase in AP1 DNA binding In addition, this increase was prevented by MAP kinase kinase inhibitor PD98059 (Fig 5A) The...
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Tài liệu Báo cáo khoa học: Kinetics and thermodynamics of nick sealing by T4 DNA ligase pptx
... Scheme [24] Scheme Kinetic scheme of self-adenylation of T4 DNA ligase ể FEBS 2003 Kinetics of nick sealing by T4 DNA ligase (Eur J Biochem 270) 4321 T4 DNA ligase binds ATPMg noncovalently, ... between the steps of transadenylation and nick- sealing Abortive adenylation leads to the build-up of the AMPndsDNA pool and to the ể FEBS 2003 Kinetics of nick sealing by T4 DNA ligase (Eur J Biochem ... ligase catalysis Joining of nicked dsDNA by T4 DNA ligase involves three catalytic steps: formation of the enzymeadenylate, formation of the ndsDNAadenylate, and sealing of the nick These processes...
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Báo cáo khoa học: Apoptosis and autophagy: Regulation of apoptosis by DNA damage signalling – roles of p53, p73 and HIPK2 ppt
... 6075 p53, p73 and HIPK2 in apoptosis N Bitomsky & T G Hofmann Fig Regulation of DNA damage- induced cell death by p53 and HIPK2 Genotoxic stress-induced DNA damage facilitates activation of the DNA ... (2009) 607 4–6 083 ª 2009 The Authors Journal compilation ª 2009 FEBS N Bitomsky & T G Hofmann p53, p73 and HIPK2 in apoptosis Fig Regulation of DNA damage- induced cell death by the p73 pathway ... apoptotic p53, p73 and HIPK2 in apoptosis signalling routes of the DDR regulated mainly from the cell nucleus and the key molecules p53, p73 and homeodomain-interacting protein kinase (HIPK2) Multiple...
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Báo cáo khoa học: Dual role of Nbs1 in the ataxia telangiectasia mutateddependent DNA damage response ppt
... its role in the DNA damage response In addition, the extreme COOH-terminal region (amino acids 734–754) of Nbs1 mediates the interaction of Nbs1 with ATM and the recruitment of ATM to sites of DNA ... MRN foci [19–21] The Mre11-binding domain of human Nbs1 has been localized to amino acids 682–693 in the COOHterminal region of the protein Deletion of this region of Nbs1 results in a cellular ... DNA damage, thereby promoting ATM-dependent signaling [23] Domains similar to the ATM-binding domain of Nbs1 are also found in ATRIP and Ku80 and are required for the interaction of these proteins...
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Báo cáo khoa học: Template-independent ligation of single-stranded DNA by T4 DNA ligase doc
... Ligation of ssDNA by T4 DNA Ligase nontemplated ligation on ssDNA substrates [29,30], this property of T4 DNA ligase has, to our knowledge, not been reported Unlike T4 DNA ligase, bacterial DNA ... ligases would also result in template-independent ssDNA ligation Oligonucleotide I was incubated with either E coli DNA ligase, Taq DNA ligase, or Ampligase Ligation Ligation of ssDNA by T4 DNA ... ª 2005 FEBS Ligation of ssDNA by T4 DNA Ligase indicate that template-independent ligation products may be avoided by using ligases such as E coli DNA ligase, Taq DNA ligase or Ampligase Finally,...
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Báo cáo lâm nghiệp: "The survey of some factors affecting bark lesion development caused by Phytophthora cactorum on common beech and other broadleaved trees" pdf
... pathogen inoculation was sycamore (mean of lesion 48.16 mm; P < 0.05) and the second one was beech (mean of lesion 22.07 mm) The differences among lesion extent on beech, alder and lime were distinct, ... experiment III Confirmation of water stress effect on lesion development The P cactorum isolate No P078.07 and 2-year old saplings of common beech were used in the experiment The inoculation process ... first and second Fig Bark lesions caused by different Phytophthora species on common beech saplings after four weeks From left to right: control, P gonapodyides, P cambivora, P cactorum, P citricola...
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Báo cáo khoa học: "Protective effect of the isoflavone equol against DNA damage induced by ultraviolet radiation to hairless mouse skin" potx
... VUSS gniwollof sllec lamred dna lamredipe ni htob ,ylralullecartni 122 ortiv ni dnuof erew sDPC ,snoitidnoc latnemirepxe ruo rednU ]41,5[ noisserppusonummiotohp dna sisenegonicracotohp htob ni elor ... VUSS retfa dna erofeb htob deilppa saw taht louqE )2 giF( erusopxe VUSS )a /b( gniwollof syad dna erusopxe VUSS ot roirp syad rof deilppa saw ti nehw ,sDPC decudni-VUSS tsniaga tcetorp ot devresbo ... stceffe evitcetorpotohp eht suht ,]82[ ecim ni seitreporp cinegonicracotohp -itna evah ot detartsnomed neeb sah louqe deilppa yllacipot dna ,sromut detaitini-noitaidar VU fo noitomorp eht rof etisiuqererp...
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Báo cáo khoa học: "Effects of DDA, CpG-ODN, and plasmid-encoded chicken IFN-γ on protective immunity by a DNA vaccine against IBDV in chickens" pps
... sulp eniccav AND 342PV -ANDcp htiw( γ-FNIhC sulp eniccav AND ,)egnellahc dna NDO-GpC sulp eniccav AND 342PV-ANDcp htiw( NDO -GpC sulp eniccav AND ,)egnellahc dna ADD sulp eniccav AND 342PV-ANDcp ... ADD sulp eniccav AND ,)egnellahc dna eniccav AND 342PV-ANDcp htiw( enola eniccav AND ,)egnellahc htiw tub eniccav tuohtiw( lortnoc egnellahc ,)egnellahc dna noitaniccav tuohtiw( lortnoc lamron ... detavitcani rof ammag-norefretni nekcihc fo tceffe tnavujdA M arumakaN ,Y ozimokoY ,T atagaN ,M awakimaK ,R ammupanattuR ,K ihsayaboK ,K arahekaT 93 955-055 ,831 ,3002 la te hoR gnuJ aH 863 ...
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Báo cáo khoa học: "Radiosensitization and growth inhibition of cancer cells mediated by an scFv antibody gene against DNA-PKcs in vitro and in vivo" docx
... and growth inhibition of cancer cells mediated by an scFv antibody gene against DNA-PKcs in vitro and in vivo Radiation Oncology 2010 5:70 Submit your next manuscript to BioMed Central and take ... production and radiosensitizing effect in vitro of a scFv antibody against DNA-PKcs [19] This scFv antibody was originally generated from a hybridoma cell line expressing the mAb 18-2 antibody of DNA-PKcs ... sensitize cancer cells to ionizing radiation in vitro and in vivo Radiosensitization by this scFv antibody is association with the decrease of DSBR capability and partial inhibition of DNA-PKcs kinase...
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Báo cáo khoa học: " Enhancement of radiosensitivity in human glioblastoma cells by the DNA N-mustard alkylating agent BO-1051 through augmented and sustained DNA damage response" potx
... design DNAdirected alkylating agents by linking the alkylating pharmacophore to the DNA- affinity molecules (e.g., DNA intercalating agents, DNA minor groove binder) [7,8] In most cases, the DNA- directed ... article as: Chu et al.: Enhancement of radiosensitivity in human glioblastoma cells by the DNA N-mustard alkylating agent BO-1051 through augmented and sustained DNA damage response Radiation ... dilution of 1:100 in 1% BSA The secondary antibody solution was then aspirated, and the cells were washed twice in PBS The cells were then incubated in the dark with PI (1 μg/ml) in PBS for 30 min,...
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Báo cáo y học: "Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen-induced arthritis" pdf
... (from days 32 to 66) and chronic phase (from days 66 to 158), because there was a decrease in the mean arthritis score after day 66 in wild-type mice COMP deficiency led to early onset of the disease, ... molecules of the immune system reach and bind other cartilage proteins To test whether COMP deficiency, like collagen IX deficiency, influences the antigenic/immunogenic properties of the cartilage, ... oligomeric matrix protein deficiency did not alter collagen II-specific antibody synthesis Antibodies have been shown to play an important role in arthritis onset and the severity of the disease...
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Báo cáo y học: "Erect wing regulates synaptic growth in Drosophila by integration of multiple signaling pathway" pptx
... cellular signaling to regulate synaptic growth erect wing integrates cellular signaling to regulate synaptic growth (a-d) Genetic interaction of ewg with known signaling pathways in synaptic growth regulation ... Erect wing rescues viability and synaptic growth defects of elav mutants Erect wing rescues viability and synaptic growth defects of elav mutants (a) Rescue of viability of elav mutants by ewg ... phenylalanine hydroxylase involved in dopamine and serotonin synthesis Candidates for mediating the synaptic growth phenotype from the remaining Genome Biology 2008, 9:R73 http://genomebiology.com/2008/9/4/R73...
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Oxidative and nitrosative DNA damage occurrence, measurement and mechanism
... Species 1.2 Oxidative and Nitrosative Damage in DNA 1.2.1 DNA damage Induced by Reactive Oxygen Species 1.2.2 DNA Damage Induced by Reactive Nitrogen Species 1.3 Mutagenicity of Oxidative and Nitrosative ... Nitrosative DNA Damage Products 14 17 1.4 Methods Used in the Quantitative Study of Oxidative and Nitrosative DNA Damage 1.5 Aims of this Study 18 22 1.5.1 Oxidative Damage in Mitochondria and Nuclei ... obtained mtDNA of desired purity in order to make a valid comparison of oxidative damage between mtDNA and nDNA Our data show that a possibility exists that mtDNA damage is not higher than nDNA damage, ...
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NBS1 deficiency promotes genome instability by affecting DNA damage signaling pathway and impairing telomere integrity
... NBS1 DEFICIENCY PROMOTES GENOME INSTABILITY BY AFFECTING DNA DAMAGE SIGNALING PATHWAY AND IMPAIRING TELOMERE INTEGRITY HOU YANYAN (Bachelor of Science, ... 84 4.1 NBS1 deficiency affects the DNA damage response 84 4.2 NBS1 deficiency compromises telomere integrity 92 IV 4.3 NBS1 deficiency promotes genome instabilities and is implicated ... the central of DNA damage signaling pathways About 25 substrates of ATM and ATR have been identified, and many of them have been revealed as candidates in DNA damage signaling pathway that play...
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Từ khóa: dna damage signaling downstream of atmm shoffner jm lott mt wallace dc 1992b association of mitochondrial dna damage with aging and coronary atherosclerotic heart disease mutat res 275 169 180step by step dna replication process animationsimple step by step dna replicationeasy step by step dna replicationstep by step dna replication animationemerging technologies for genome wide profiling of dna methylationanalysis of microsatellite instability by micro fl uidic based electrophoresishla typing by direct dna sequencingdna damage caused by oral malodorous compounds in periodontal cells in vitro novel carcinogenic pathwayλ by motor dna complex assemblymeasurement of dna damage in spermatozoa by tunel assaydna damage caused by endogenously generated products of oxidative stressploidy genome instability and cancerttc0096 by nterminal amino acid sequence analysis and malditofmsBáo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Định tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Thơ nôm tứ tuyệt trào phúng hồ xuân hươngSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)chuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)Đổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namMÔN TRUYỀN THÔNG MARKETING TÍCH HỢP