HDAC INHIBITOR TARGETED THERAPY WITH NANOMEDICINE INCREASES THE EFFICACY OF PACLITAXEL IN TRIPLE NEGATIVE BREAST CANCER

... efficacy in breast cancer models, which would have more impact in the field of triple negative breast cancer Treatment combining epigenetics and anti-mitotic targeted therapies could improve the therapeutic ... the TNBC cells to certain cisplatin and PARP inhibitor treatment (Bhalla et al., 2012) Thus, it would be interesting to further explore the therapeutic effects of vorinostat in TNBC with another ... chemotherapy regime such as taxanes 1.5 Combination Chemotherapy with Paclitaxel Taxanes or microtubule inhibitors are recognized as effective anticancer drugs in the treatment of breast cancers...

báo cáo hóa học:" Enhancing the efficacy of cisplatin in ovarian cancer treatment – could arsenic have a role" potx

... Chemotherapy The most active chemotherapy agents in ovarian cancer are the platinum analogues, cisplatin and carboplatin The antitumor activity of cisplatin (cis-diamminedichloroplatinum (II)) was ... platinum-sensitive human ovarian cancer cell line OVCAR They also appeared to slow the growth of the cisplatin- sensitive human ovarian cancer cells GG and JAM [85] Arsenic trioxide and cisplatin had additive ... Aabo K, Adams M, Adnitt P, et al.: Chemotherapy in advanced ovarian cancer: four systematic meta-analyses of individual patient data from 37 randomized trials Advanced Ovarian Cancer Trialists'...

báo cáo khoa học: "Treatment options for patients with triple-negative breast cancer" docx

... irinotecan/carboplatin with or without cetuximab in patients with metastatic breast cancer Breast Cancer Res Treat 2007, 106:S32-S33 Carey LA, O’Shaughnessy JA, Hoadley K, Khambata-Ford S, Horak CE, ... expression profiling study of 99 patients with breast cancer, 41 of whom had triple negative disease They noticed that nine of the patients with TNBC clustered together with the ER positive group When ... combination of doxorubicin plus cyclophosphamide followed by paclitaxel for patients with TNBC, in the adjuvant setting For patients with metastatic disease, there is no standard first line agent to...

Báo cáo y học: "A randomized, double-blind, placebo-controlled trial to assess the efficacy of topiramate in the treatment of post-traumatic stress disorder" pot

... will compare the efficacy of topiramate with placebo in the treatment of PTSD, and will study its tolerability through the drop out rate in each group The primary hypothesis is that topiramate ... superior to placebo in the treatment of PTSD Secondary research goals includes studying the efficacy of topiramate in social adjustment, functioning and quality of life Additionally, evaluating treatment ... PTSD is challenging due to the complexity of the symptoms and psychiatric comorbidities Psychotherapy and pharmacotherapy are the two main classes of PTSD treatment In the Cochrane systematic review,...

Báo cáo khóa học: The proteasome inhibitor, MG132, promotes the reprogramming of translation in C2C12 myoblasts and facilitates the association of hsp25 with the eIF4F complex pptx

... reorganization of the actin ﬁlament system, playing a role in the migration of endothelial cells and in recovery of cells from wounding [40] In a variety of cells, in addition to the induction of hsp25 and ... MG132 and the reprogramming of translation (Eur J Biochem 271) 3605 A B C Fig Inhibition of p38MAP kinase activity attenuates the induction of hsp25 and prevents its interaction with the eIF4F complex ... before the addition of recombinant hsp25, as described in Materials and methods Following isolation and washing of the resin, protein was eluted and visualized by SDS/PAGE and Coomassie staining The...

Báo cáo y học: " Secondary infection with Streptococcus suis serotype 7 increases the virulence of highly pathogenic porcine reproductive and respiratory syndrome virus in pigs" potx

... Secondary infection with Streptococcus suis serotype increases the virulence of highly pathogenic porcine reproductive and respiratory syndrome virus in pigs Virology Journal 2010 7: 184 Submit your ... Li Y, Wang X, Bo K, Tang B, Yang B, Jiang W, Jiang P: Emergence of a highly pathogenic porcine reproductive and respiratory syndrome virus in the Mid-Eastern region of China Vet J 20 07, 174 : 577 -584 ... of the coinfected group reached 41°C, and in of the pigs the temperature reached 41.5°C, and the number of neurologic symptoms in these pigs increased significantly Secondary infection with the...

Báo cáo y học: "Evaluating the efficacy of sequential biologic therapies for rheumatoid arthritis patients with an inadequate response to tumor necrosis factor-a inhibitor" ppsx

... Evaluating the efficacy of sequential biologic therapies for rheumatoid arthritis patients with an inadequate response to tumor necrosis factor-a inhibitors Arthritis Research & Therapy 2011 13:R25 ... TA, Uffmann M, Smolen JS: Benefit of very early referral and very early therapy with disease-modifying antirheumatic drugs in patients with early rheumatoid arthritis Rheumatology (Oxford) 2004, ... while tumor necrosis factor (TNF)-a inhibitors were consistently recommended for patients with active RA and a history of inadequate response to synthetic DMARDs [5], the management of patients...

Báo cáo y học: "Evaluating the efficacy of sequential biologic therapies for rheumatoid arthritis patients with an inadequate response to tumor necrosis factor-a inhibitor" pps

... history with consequent exclusion of these five patients would lead to an increased specificity of 99.5% at the manufacturer’s threshold Analysis of test criteria To further assess the performance ... significantly better than the anti-dsDNA ELISA (p = 0.0024 and p = 0.0029, respectively) The Farr assay was not significantly better than any other ELISA, nor was the opposite the case The Anti-dsDNA-NcX ... (free of Scl-70 and histone H1) and the Farr assay in sera from 964 individuals by using ROC curve analysis (Table 1) To check whether the performance of a single test system was significantly better...

Báo cáo y học: "The association between systemic glucocorticoid therapy and the risk of infection in patients with rheumatoid arthritis: systematic review and metaanalyses" pptx

... al.: The association between systemic glucocorticoid therapy and the risk of infection in patients with rheumatoid arthritis: systematic review and meta-analyses Arthritis Research & Therapy 2011 ... literature review and meta-analysis (where appropriate) of RCTs and observational studies to assess the association between systemic GC therapy and the risk of infection in patients with RA, compared with ... by which they captured infection, nonreporting of infection within the results was assumed to represent no infections in either group Absent reporting of infection that was in any way ambiguous...

The application of games in teaching grammar with reference to tieng anh 10 textbook at ha trung high school, thanh hoa province

... 2.1 Ha Trung high school and current situation of teaching and learning English at the school 2.1.1 Ha Trung high school 10 Ha Trung high school is one of the leading schools in Thanh Hoa province ... deals with the theories of the role of grammar, students’ motivation, and the application of games in teaching grammar It is important that it is carried 35 out to investigate the application of games ... teaching and learning grammar? - What benefits does the application of games in teaching grammar bring to teachers and students? - What kinds games should be used to teach the grammar of Tieng Anh...

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Tài liệu Signaling Status with Luxury Goods: The Role of Brand Prominence docx

... in Interbrand’s ranking of the leading luxury brands of 2008 (Interbrand 2009) In addition, they are rated #2 and #3, respectively, on the Luxury Institute’s list of the most familiar luxury handbag ... larger sample of non-patricians with the hope of insuring we had significant representation from each of the three other classes of consumers The zip codes, along with these measures of income and ... to the haves that they are part of their group The irony is, of course, that while many parvenus believe they are saying to the world that they are not have-nots, in reality, they may also be signaling...

Tài liệu Signaling Status with Luxury Goods: The Role of Brand Prominence ppt

... (2009) ranking of the leading luxury brands of 2008, and they are rated second and third, respectively, on the Luxury Institute’s list of the most familiar luxury handbag brands (see www.luxuryinstitute.com) ... sample of nonpatricians with the hope of ensuring a significant representation from each of the three other classes of consumers The zip codes, along with these measures of income and need for status, ... to copy, they determine the price of their offerings on the basis of the price charged by the original manufacturer (β = 03, p < 01) In other words, counterfeiters price their knockoffs higher...

Tài liệu Báo cáo khóa học: The C-terminal domain of Escherichia coli Hfq increases the stability of the hexamer ppt

... The role of the C-terminal domain on Hfq (Eur J Biochem 271) 1259 the model further conﬁrmed by determination of the X-ray structure of Staphylococcus aureus and E coli Hfq proteins [19,20] Hfq ... binding of the polyadenylated rpsO RNA We have shown that the presence of the remainder of the acidic tail results in the thermodynamic stabilization of Hfq by 1.8 kcalÆmol)1 A comparison of the ... Figure shows the binding curves of Hfqf and Ó FEBS 2004 The role of the C-terminal domain on Hfq (Eur J Biochem 271) 1261 Fig Multiple sequence alignment of various bacterial Hfqs The alignment...

Báo cáo khoa học: Structure of the complex of a yeast glucoamylase with acarbose reveals the presence of a raw starch binding site on the catalytic domain doc

... GLU R1 5A forward (5¢-ATTCAAACTATAAAGTTGACGCAA CTGACTTGGAAACCTTC-3¢), GLU R1 5A reverse (5¢GAAGGTTTCCAAGTCAGTTGCGTCAACTTTATAGTT TGAAT-3¢); GLU H44 7A forward (5¢- GCAAGTCATTT TGGATGCTATTAATGATGATGGCTC-3¢), ... form any additional contacts with the molecule A 2164 Catalytic site The catalytic reaction of glucoamylases proceeds with inversion of conﬁguration at the anomeric carbon which requires a pair of ... H44 7A reverse (5¢- GAGCCATCATCATTAATAGCATCCAAAA TGACTTGC-3¢); GLU T46 2A forward (5¢- GAACAACTT AACAGATATGCCGGTTATTCCACCGGTGCC-3¢), GLU T46 2A reverse (5¢- GGCACCGGTGGAATAACCGGCA TATCTGTTAAGTTGTTC-3¢);...

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