Role of multidrug resistance associated protein 4 (MRP4 ABCC4) in the resistance and toxicity of oxazaphosphorines

... resistance profiles of MRP4/ABCC4 to oxazaphosphorines including CP and IF in the absence and presence of various MRP4/ABCC4 inhibitors or MRP4/ABCC4 inducers by using the MRP4/ABCC4 overexpressing HepG2 ... interesting to investigate the effect of the combination of oxazaphosphorines and -x- MRP4/ABCC4 inhibitors on cancer treatment, and to investigate the effect of MRP4/ABCC4 on the toxicity of CFB - ... substrate of MRP4/ABCC4 and a modulator of MRP4/ABCC4 in vitro Further studies are needed to explore the effect of MRP4/ABCC4 on the transport of oxazaphosphorines and CFB It would also be interesting...

Effects of plant polyphenols and mutational analysis of multidrug resistance protein 4 (MRP4 ABCC4) functions

... EFFECTS OF PLANT POLYPHENOLS AND MUTATIONAL ANALYSIS OF MULTIDRUG RESISTANCE PROTEIN (MRP4/ ABCC4) FUNCTIONS WU JUAN (B.M., Peking University) A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF ... by MRP4/Hep G2 cells 84 4.1 .4 Effects of plant polyphenols on GSH efflux mediated by MRP4 87 4. 2 Cloning and expression of mutant MRP4 93 4. 2.1 PCR 93 4. 2.2 Cloning of mutant ... Functional study of MRP4 protein .75 4. 1.1 Export of bimane-GS by MRP4/Hep G2 cells 75 4. 1.2 Effects of plant polyphenols on bimane-GS efflux mediated by MRP4 78 4. 1.3 Export of reduced...

Báo cáo khoa học: Cell death-inducing DFF45-like effector, a lipid droplet-associated protein, might be involved in the differentiation of human adipocytes pdf

... suggesting that CIDEC might be a target of PPARc transactivation These data suggest that CIDEC may not only be a downstream target of PPARc transactivation, but is also likely to be involved in a ... human adipocyte differentiation F Li et al mRNA in 3T3-L1 adipocytes, whereas the expression of a dominant-negative mutant of PPARc results in a decrease in the amount of Fsp27 mRNA in 3T3-L1 adipocytes ... conﬂuence After 14 days of induction, the majority of the cells displayed a phenotype of mature adipocytes (Fig 4A) The neutral 4176 lipids accumulated in the cytoplasm, and a large number of lipid...

Báo cáo khoa học: Isothermal unfolding studies on the apo and holo forms of Plasmodium falciparum acyl carrier protein Role of the 4¢-phosphopantetheine group in the stability of the holo form of Plasmodium falciparum acyl carrier protein docx

... The chaotrope-induced unfolding was almost fully reversible in both forms of the protein Removal of the perturbation makes the protein regain its native form The unfolding reactions of both forms ... as the major and the minor forms of the holoACP structure, on the basis of their percentage contributions (65% and 35%, respectively) to the overall structure of the protein The structures of the ... better stability than the other form (Fig 4C) The DG of stability is on an average 20% greater in the case of the holoprotein as compared to the apoprotein Similarly, the Cm of the holo form always...

Tài liệu Báo cáo khoa học: Competition between innate multidrug resistance and intracellular binding of rhodamine dyes pdf

... pumping of the agents out of the cells and their passive uptake [10,31] and (b) competition between the active pumping of the agents out of the cells and their intracellular binding to receptors and ... allowing the enhanced uptake of rhodamine dyes inhibited the efﬂux of these dyes from the cells The efﬂux of rhodamine 123 and TMRM was inhibited by NBD-Cl and MK571 and, to a lesser extent, by ... they are hydrophobic and negatively charged A comparison of rhodamine uptake, in the presence and the absence of uncouplers, allows the estimation of the effect of intracellular binding on the MDR...

Analysis of regulator of g protein signaling (RGS) function in growth, development and pathogenicity of magnaporthe grisea 4

... Figure 39 WT rgs1D Figure 40 Figure 41 Figure 42 _ Figure 43 - Gd + Gd, 1h + Gd, 0h + Gd, 2h + Gd, 0.5h + Gd, 3h _ Figure 44 A WT rgs1D Solvent Solvent 10mM 8-Br-cAMP 10mM 8-Br-cAMP _ B WT rgs1D ... Solvent 10mM 8-Br-cAMP 10mM 8-Br-cAMP _ B WT rgs1D Figure 45 Appressorium formation on inductive membrane (%) Appressorium formation on Noninductive membrane (%) WT 89 1.5 mscL∆ 92 mscS1∆ 87 2.5 ... mscS1∆ 87 2.5 mscS2∆ 91 mscS3∆ 85 mscL∆mscS1∆ 86 mscL∆mscS2∆ 92 1.5 mscL∆mscS3∆ 88 mscS1∆mscS2∆ 84 mscS1∆mscS3∆ 85 mscS2∆mscS3∆ 89 ...

Tài liệu The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States: A Joint Statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory Committee on Immunization Practices docx

... Atlanta, GA 30333 SUGGESTED CITATION Centers for Disease Control and Prevention The role of BCG vaccine in the prevention and control of tuberculosis in the United States: a joint statement by ... Committee and the Advisory Committee for Elimination of Tuberculosis published a joint statement on the use of BCG vaccine for the control of TB (2 ) Based on available information concerning the effectiveness ... vaccination in the prevention and control of TB in the United States CDC, the Advisory Council for the Elimination of Tuberculosis (ACET), and the Advisory Committee on Immunization Practices (ACIP),...

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Tài liệu Báo cáo khoa học: NMR structural characterization of HIV-1 virus protein U cytoplasmic domain in the presence of dodecylphosphatidylcholine micelles doc

... bear structural similarity to the tight loop formed by L73–V78 of VpUcyt in the presence of DPC micelles Although the structural motifs adopted by the cytoplasmic domain of VpU appear to be qualitatively ... structure of the cytoplasmic domain of the human immunodeﬁciency virus type encoded virus protein U (Vpu) Int J Pept Protein Res 47, 297–310 Willbold D, Hoffmann S & Rosch P (1997) Secondary ¨ structure ... Schomburg D (1993) Synthesis and characterization of the hydrophilic C-terminal domain of the human immunodeﬁciency virus type 1-encoded virus protein U (Vpu) Pept Res 6, 79–87 Wray V, Federau T,...

Tài liệu Báo cáo khoa học: Inorganic pyrophosphatase in the roundworm Ascaris and its role in the development and molting process of the larval stage parasites doc

... that the hypodermis of the body wall, which synthesizes components of the cuticle, may offer a useful target for studies into the mechanism of the development and molting process in the roundworms ... presence of increasing concentrations of inhibitors for 10 days, and the number of molting larvae was determined Molting was manifested by shedding of the L3 cuticle Results Identiﬁcation of cDNA ... involved in the molting process, we examined the effects of two PPase speciﬁc inhibitors, imidodiphosphate (IDP, 1-0631; Sigma) and NaF on development and molting of A suum lungstage L3 to fourth-stage...

Báo cáo khoa học: Spatio-temporal distribution of fatty acid-binding protein 6 (fabp6) gene transcripts in the developing and adult zebraﬁsh (Danio rerio) pptx

... Spatio-temporal distribution of cellular retinol-binding protein gene transcripts (CRBPI and CRBPII) in the developing and adult zebrafish (Danio rerio) Eur J Biochem 271, 339–348 Ohmachi T, Inoue ... Alves-Costa et al The zebrafish fabp6 gene Distribution of fabp6 gene transcripts in zebrafish embryos and larvae Fig A neighbor-joining tree showing the phylogenetic relationship of zebrafish Fabp6 with selected ... the AB strain of zebrafish (see http://zfin.org for strain details) The zebrafish fabp6 gene The coding sequence of the fabp6 gene contained an open reading frame of 393 bp (not including the stop...

Báo cáo khoa học: Identiﬁcation of multiple isoforms of the cAMP-dependent protein kinase catalytic subunit in the bivalve mollusc Mytilus galloprovincialis potx

... mussel M galloprovincialis Results Separation of different isoforms of the C -subunit In order to demonstrate the presence of different isoforms of the PKA C -subunit in mussels, the protein was ... isoforms [33] In summary, in this work we demonstrate the presence of several structurally different isoforms of the PKA C -subunit in mussel tissues In principle, the combination of these catalytically ... tissuespeciﬁc protein kinase (Cc) from human testis – representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase Mol Endocrinol 4, 465–475 22 Gross RE, Bagchi S, Lu X & Rubin...

Báo cáo khoa học: The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B1 and B2 bradykinin receptors potx

... in Role of helix and C-termini in bradykinin receptors receptor signaling because: (a) interruption of the amphipathic structure of B1wt helix in B1wt and B1KB2 through the presence of a serine ... TSIfiAAA N3 38* B1wt B1RB2 B1NB2 B1CB2 B1KB2 B1KB2 ⁄ SfiV B1KB2 ⁄ QGVfiKQ B1KB2 ⁄ VCfiCV B1YB2 B1V323S 10400 5020 52 98 383 2 625 127 511 1701 182 3 17 58 2142 1 786 2957 84 6 3.91 ± 1.06 3.76 ± 1.61 2 .82 ± 0.92 ... Faussner et al Role of helix and C-termini in bradykinin receptors Fig Schematic representation of the C-terminal B1wt and B2wt sequences and chimera thereof The C-terminal sequences beginning at transmembrane...

Báo cáo khoa học: Differential tissue-speciﬁc distribution of transcripts for the duplicated fatty acid-binding protein 10 (fabp10) genes in embryos, larvae and adult zebraﬁsh (Danio rerio) docx

... show differential tissue-specific distribution of fabp10a and fabp10b transcripts in developing and adult zebrafish, evidence of the divergence of regulatory elements in the promoters of the fabp10a ... vesicles indicates a potential role for this protein in the early development of the zebrafish brain Tissue-specific distribution of fabp10b gene transcripts in adult zebrafish The tissue-specific distribution ... transcripts in embryos, larvae and adult zebrafish show strikingly different tissue-specific patterns of distribution On the basis of the distribution of fabp10b transcripts in many tissues of adult zebrafish, ...

Báo cáo khoa học: Molecular dissection of the biosynthetic relationship between phthiocerol and phthiodiolone dimycocerosates and their critical role in the virulence and permeability of Mycobacterium tuberculosis doc

... postinfection, we observed a marked difference between the number of CFUs of the wild-type strain and that of the PMM56 mutant strain in lungs and in the spleen (Fig 7A) Indeed, both strains ... cell envelope of M tuberculosis and to virulence [3–6] Nevertheless, their precise molecular mechanisms of action are still unknown, and the speciﬁc roles of the various members of the DIM family, ... DIM A and DIM B, in these functions have never been investigated The recent developments in our understanding of the biosynthetic pathway of DIMs have provided the means to investigate the contribution...

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