... default rates as continuousrandom variables and incorporates the volatility ofthe default rate in order to capture the uncertainty in the level ofthe default rate. A mapping from credit ratings ... the actual default rate might be a similarquantity. Then there will be a substantial chance in any year ofthe actual average probability of default in the sector being, say, 10% instead of 5%. ... banking firm, providing comprehensivefinancial advisory, capital raising, sales and trading, and financialproducts for users and suppliers of capital around the world. It operates in over 60 offices...
... [Ca2+]changes inthe ER lumen are sensed by the canonicalEF-hand motif and cause conformational changes in this motif. The Ca2+signal change andthe accompa-nying conformational change inthe canonical ... that the isolatedcanonical EF-hand alone has an intrinsic tendency toform a dimer, which is in agreement with the EF-handpairing paradigm. Clearly, the canonical EF-handmotif alone is able ... engineeredprotein CD2.STIM1.EF increased, indicating that the inserted EF-hand motif at least partially maintains the natural helical structure after grafting. The Ca2+dis-sociation constant of CD2.STIM1.EF...
... storage. The players left Dallas and never returned. The Texans‘ only hurrah came ina Thanksgiving Day game in Akron, Ohio, against the Bears. Three thousand fans were inthe stands on a dank afternoon. ... final scores and salient details of every game the Cowboys had played for as long as I could remember. My grandfather, whom we called Pop, was amazed and amused by his grandson, the walking ... because when he did he would sit there coaching the team and calling plays before the ball was snapped, and my grandfather couldn‘t stand to listen to him. I was the youngest, the baby of the...
... thrombin and PAI-1 in thevesselwallhastwofaces.First,PAI-1isabletoinhibit the mitogenic potential of thrombin. On the other hand,cleavage and inactivation of PAI-1 by thrombin controls the urokinase-type ... is an inactivation ofthe PAI-1 pool in the vascular wall by thrombin, making it no longer available for interaction with u-PA and VN, which can explain part of the effect of thrombin on the ... orcan result in cleavage ofthe inhibitor and release of activeenzyme. A decreased overall inhibition rate can thus be the result ofa shift ofthe rate constants ofthe branched part of mechanism,...
... retail and institutional share classes of long-term mutual funds. Including institutional share classes is appropriate because the vast majority ofthe assets inthe institutional share classes ... brokers and other financial professionals who sell mutual funds have increasingly been compensated through “asset-based” fees (assessed as a percentage ofthe assets that the financial professional ... inthe fund’s name.These features have made lifestyle and target date funds especially attractive for individuals saving for retirement in 401(k) plans and IRAs.6 Lifestyle and target date...
... professional manages for an investor, rather than as a percent ofthe dollars initially invested. Over time, brokers and other financial professionals who sell mutual funds have increasingly ... excludes assets of mutual funds available as investment choices in variable annuities and mutual funds that invest primarily in other mutual funds. Assets are plotted as a two-year moving average. ... compared with a decline of 11 basis points for actively managed equity funds. Similarly, the average expense ratios of index and actively managed bond funds have fallen 8 and 16 basis points,...
... rubberfarming systems vary within Southeast Asia. Inthe beginning ofthe 20th century, estateplanting was encouraged in Malaya, while in Thailand andthe Netherlands Indies rubberbecame an important ... different amounts of rainfall. The Northeast of Thailand has beenpromoted for rubber plantation establishment, and, on the other hand, considerable variation in the amount of rainfall exists within the ... observations The owners of each plantation were interviewed in Thai with the help ofa translator. The basic information of planted clone, area of plantation and age ofthe trees was obtained in thisway....
... for supporting the project andfor sharing so much information. Confidentiality has been maintained. A big thank you to Deborah Haylett and Finn, Ermias Alemu, Sasha Rozansky and Mahi Salih ... psychotherapeutic and counseling treatment, as well as pharmacological interventions that are culturally appropriate and effective, [and] a workforce and organisation capable of delivering appropriate and ... hand note-taking only. All interviews were carried out with informed-consent and transcribed. The researchers charted the data for thematic analysis according to the principles ofthe Framework...
... glutamine and aspara-gine [1]. Glutaminase is found in many organisms,including mammals, fungi, yeasts and bacteria [1–5].Glutaminase from Micrococcus luteus K-3 (Mglu) and AoGlS glutaminase ... specific for l-glutamine, withthat of Erwinia carotovora asparaginase, which has substrates other thanl-glutamine, shows that Mglu has a larger substrate-binding pocket thatprevents the binding of ... crystalstructures andthe conserved amino acid residues (aa) of their active sites, these glutaminases are classifiedinto a large group of bacterial penicillin-bindingproteins and b-lactamases [5,10].Most...
... hotline activated, a rousing speech and memorandum from the CEO is delivered, and an “ethics officer” appointed, then all the employees and managers will join hands ina “Kumbaya” moment, andthe ... been a series of further scandals and settlements involving Wall Street analysts, mutual funds, as well as the insurance, healthcare and pharmaceutical industries. Beyond the scandals in these ... table advocated for this kind of split, and particularly forthe role ofa very strong compliance officer who stands up as an enforcer against senior management, others (including several of the...
... CGCGCTAGCATGATCAAGGACTGTGGGCAGCCC and CGCGAATTCTCACACTGGCAAGCACCGAGGAATCT;CCP1CCP2: CGCGCTAGCATGATCATCAAGTGCCCCCAGCCC and CGCGAATTCTCACACTGGCAAGCACCGAGGAATCT;CUB2CCP1: CGCGCTAGCATGACTCAGGCTGAGTGCAGCAGC and ... the b-strands. The loops between strands B and C, knownas the ‘hypervariable loop‘, D and E, E and F, F and G, and G and H are particularly tolerant of longerinsertions [19]. In multimodular ... observation that the internal dynamics ofa module can be modulated byneighboring domains offers a new way to understand the regulation of multidomain proteins and challenges the generally accepted...
... GACTAGTTTAAACGGATCGACGAGTTCGACGCppsE2 GACTAGTTTAAACGAGGCACTGTGACCAGATGCppsE3 CGTTCTGGAGCAACCTTCGppsE4 GGTCGAGGAAGTACGTGACres res1 GCTCTAGAGCAACCGTCCGAAATATTATAAAres2 GCTCTAGATCTCATAAAAATGTATCCTAAATCAAATATCPhthiocerol ... AGGAAGGCCGGCAAATGGC2951D TTCACGTGAGATAAGCTCCC2951E ACGGTTTCGGTGAAGCCAG2951L ACAATTAATTAACAGTATGTACGAGCGATGCG2951M ACAAAAGCTTGGCGCAAATCATAGCTTCTTGppsE ppsE1 GACTAGTTTAAACGGATCGACGAGTTCGACGCppsE2 GACTAGTTTAAACGAGGCACTGTGACCAGATGCppsE3 ... mutants andthe analysis of theirgrowth characteristics in various cellular and animalmodels may lead to the identification ofthe structuralmotif(s) of DIMs involved in pathogenesis, and thereby...