... larger extracellular domain of CD4 and its close proximity to CXCR4 on the cell membrane may be the reason for the selection of CD4 PhAbs by Pathfinder selection guided by the CXCR4 mAb 12G5 In addition, ... characterization of selected scFvs showed that none of them were CXCR4 specific, although antibodies against CD4 and transferrin receptor (TfR, CD71) were identified Some of the limitations of these selection ... was from the second round of Pathfinder selection, and the other, designated 92, was from the third round of Pathfinder selection Analysis of clone diversity The diversity of the 59 Jurkat cell-positive...