GENOME WIDE ASSOCIATION STUDIES OF CORONARY ARTERY DISEASE IN SINGAPOREAN CHINESE POPULATIONS

... Singapore Coronary Artery Genetics Study xv SCES: Singapore Chinese Eye Study SCES: Singapore Chinese Eye Study SCHS: Singapore Chinese Health Study SiMES: Singapore Malay Eye Study SINDI: Singapore ... that studies of coronary artery disease in Asia are conducted to address this increasing burden 1.3 Overview of the etiology of coronary artery disease The etiology of CAD is multifactorial, involving ... findings 2.3.1 GWAS of CAD Genome wide association studies have identified multiple genetic variants associated with CAD Most of the associations have been replicated in independent studies, indicating...

A genome wide association study of pulmonary tuberculosis susceptibility in Indonesians doc

... monozygous twins, full siblings, and parent-offspring In each instance, the sample with the higher call-rate was retained in the analysis Analysis of association statistics After sample and SNP quality ... Working Group, Medical Faculty, University of Indonesia, Jakarta, Indonesia 8Samara Oblast Tuberculosis Dispensary, Samara City, Samara, Russian Federation 9Clinical TB and HIV Group and Health ... and sampling sample in Russia SN participated in sample collection in Russia and association analysis of the Russian data Competing interests The authors declare that they have no competing interests...

báo cáo khoa học: " Moderate- to low-risk variant alleles of cutaneous malignancies and nevi: lessons from genome-wide association studies" pdf

... susceptibility to melanoma may also result in high-risk predisposition to other such forms of cutaneous malignancies [12] Risk variants of cutaneous malignancies Association with pigmentation phenotype and ... 1)) for CM and BCC risk Three cohorts (810 individuals with CM and 36,723 non-CM controls from Iceland; 1,033 CM cases and 2,650 controls from Sweden and 278 CM cases and 1,297 controls from Spain) ... association BCC, no association to CM KRT5, G138E substitution [12] No association BCC, no association to CM 7q32 adjacent to KLF14 [12] No association BCC, no association to CM MTAP rs4636294...

Báo cáo y học: " DNA microarray analysis of rheumatoid arthritis susceptibility genes identified by genome-wide association studies" docx

... as: Sugino H, et al.: DNA microarray analysis of rheumatoid arthritis susceptibility genes identified by genome-wide association studies Arthritis Research & Therapy 2010, 12:401 ... financially supported partly by the grant from the Ministry of Health, Labor and Welfare of Japan Author details Graduate School of Frontier Bioscience, Osaka University, 1-3 YamadaOka, Suita-City, ... Sugino et al Arthritis Research & Therapy 2010, 12:401 http:/ /arthritis- research.com/content/12/2/401 Page of Table Candidate genes identified from rheumatoid arthritis genome-wide association...

ASSOCIATION OF CETP AND ADTRP GENES WITH CORONARY ARTERY DISEASE IN MULTI ETHNIC SINGAPOREAN POPULATION

... consisting of Telugas and Tamils from southeastern India and a minority of Sikhs and Pathans from north India and accounts for 7.9% of the Singapore population The immigrant Chinese and Indians ... ethnic Chinese were not different from that in the ethnic Indians, in spite of a much lower CAD incidence in the ethnic Chinese (57) Because of Singapore's multiracial population structure and differential ... 76.7% of the resident Singaporean population The Malay population account for 13.9% of the Singapore population (52) Moreover, the Indian migrants in Singapore were from the Indian subcontinent, with...

Báo cáo y học: "Two-year Outcome of Turkish Patients Treated with Zotarolimus Versus Paclitaxel Eluting Stents in an Unselected Population with Coronary Artery Disease in the Real World: A Prospective Non-randomized Registry in Southern Turk

... results of these initial trials indicate that the ZES is safe and reduces the rates of clinical and angiographic restenosis in patients with symptomatic coronary artery disease (CAD; 4) Also the safety ... Abbreviations ACC: American College of Cardiology; AHA: American Heart Association; CABG: coronary artery binding graft; CK: creatine kinase; MACE: major adverse cardiac events; MI: myocardial infarction; ... between the ZES and the PES treated groups with the Kaplan-Meier method and log-rank test A P value < 0.05 was considered statistically significant RESULTS Baseline clinical, coronary angiographic and...

Báo cáo khoa học : Tissue Doppler imaging for the diagnosis of coronary artery disease ppt

... KW, et al .: Color Doppler myocardial imaging: a new technique for the assessment of myocardial function J Am Soc Echocardiogr 1994, 7:4 41–458 Tissue Doppler imaging and coronary artery disease ... different there is deformation of the tissue in between In the case that the two locations are getting closer there is myocardial shortening, and when they move apart there is lengthening Strain ... Non-invasive diagnosis of coronary artery disease by quantitative stress echocardiography: optimal diagnostic models using off-line tissue Doppler in the MYDISE study Eur Heart J 2003, 2 4:1 584–1594...

Báo cáo y học: "Genome-wide association studies in systemic lupus erythematosus: a perspective" docx

... the key pathways involved in lupus pathogenesis, with each pathway constructed of a number of interacting proteins making an individual contribution to disease susceptibility Page of (page number ... Arthritis Research & Therapy Vol 11 No Cunninghame Graham reproducibility between GWAS may reflect an overall lack of power for each individual study, since each published GWAS was of intermediate ... Yin H, Baechler EC, Li QZ, Wakeland EK, Bruner GR, et al.: Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and...

Báo cáo y học: "Meta-analysis of genome-wide linkage studies of asthma and related traits" potx

... consistency of results across studies and to identify regions that contain asthma and atopy susceptibility genes The aim of the current study was to complete the first meta-analysis of available ... analysis combines data from 10 years of asthma and atopy genetics and is extremely timely providing a definitive analysis of available linkage data to complement the highly anticipated whole genome ... study represents the first meta-analysis of asthma and related trait linkage data using the majority of the data available for the Caucasian asthma cohorts in the public domain This analysis...

Báo cáo y học: " Importance of cumulative exposure to elevated cholesterol and blood pressure in development of atherosclerotic coronary artery disease in systemic lupus erythematosus: a prospective proof-of-concept cohort study" pdf

... Importance of cumulative exposure to elevated cholesterol and blood pressure in development of atherosclerotic coronary artery disease in systemic lupus erythematosus: a prospective proof -of- concept ... erythematosus, atherosclerosis, coronary artery disease, risk factors Introduction Systemic lupus erythematosus (SLE) is associated with a dramatically increased risk of atherosclerotic coronary artery disease ... were a total of 94 coronary events (75 angina, 25 MI and sudden cardiac deaths; had both angina and MI) in the BP dataset, while the TC dataset contained 86 coronary events (71 angina, 20 MI and...

Model selection methods and their application in genome wide association studies

... feature selection methods conﬁned to genome- wide association studies in Subsection Chapter1: Introduction 1.3.1 Model selection methods and some feature selection methods incorporated into model selection ... original SCAD method Chapter 3: Model selection criterion in generalized linear models 37 Chapter Model Selection Criteria in Generalized Linear Models In model selection, optimization of a model ... selection are reviewed in Subsection 1.3.2 1.3.1 Feature selection methods in genome- wide association studies In genome- wide association studies, a large number of statistical studies have been developed...

Genetic epidemiology of coronary artery disease

... Summary viii List of Publications x List of Abbreviations xi List of Tables xiv List of Figures xv Introduction to Coronary Artery Disease 1.1 Definition of coronary artery disease ... Cumulative age distribution of mt5178C and mt5178A subjects 65 xv Chapter Introduction to Coronary Artery Disease 1.1 Definition of coronary artery disease Ischemic heart disease is the generic ... risk factors of coronary artery disease 1.5 Conventional risk factors of coronary artery disease The risk factors that predispose to the atherosclerosis and resultant ischemic heart disease have...

Báo cáo khoa học: Genome-wide identiﬁcation of glucosinolate synthesis genes in Brassica rapa potx

... et al Glucosinolate biosynthesis genes in Brassica rapa Fig Biosynthesis pathways of the three major groups of glucosinolates in B rapa The genes involved in each step are shown Numbers in parenthesis ... expression of Arabidopsis glucosinolate synthesis genes altered the glucosinolate proﬁle in Chinese cabbage [50,51] Because most of the Arabidopsis genes encoding glucosinolate biosynthesis pathways ... Halkier BA (2008) Subclade of ﬂavin-monooxygenases involved Glucosinolate biosynthesis genes in Brassica rapa 29 30 31 32 33 34 35 36 37 38 39 in aliphatic glucosinolate biosynthesis Plant Physiol...

Low-Carbohydrate-Diet Score and the Risk of Coronary Heart Disease in Women potx

... intake of fat and protein and a lower intake of carbohydrate) The association between the low-carbohydrate-diet score and the risk of coronary heart disease was examined Results During 20 years of ... fat and protein intake and the highest carbohydrate intake) to 30 (the highest protein and fat intake and the lowest carbohydrate intake) Therefore, the higher the score, the more closely the ... associated with increased risk of coronary heart disease in women When vegetable sources of fat and protein are chosen, these diets may moderately reduce the risk of coronary heart disease n engl...

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