fgfr2 tncr9 and map3k1 identified through genome wide association studies
báo cáo khoa học: " Moderate- to low-risk variant alleles of cutaneous malignancies and nevi: lessons from genome-wide association studies" pdf
... protein 1)) for CM and BCC risk Three cohorts (810 individuals with CM and 36,723 non-CM controls from Iceland; 1,033 CM cases and 2,650 controls from Sweden and 278 CM cases and 1,297 controls ... effort from ten GenoMEL groups with 1,650 cases and 1,065 controls The team identified five loci on chromosomes 2, 5, 9, 11 and 16, with at least one SNP at each locus with genomewide significance ... malignancies Association with pigmentation phenotype and risk of cutaneous melanoma A comprehensive meta-analysis by Gandini and colleagues [13] revealed a direct link between pigmentation and melanoma...
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Báo cáo y học: " DNA microarray analysis of rheumatoid arthritis susceptibility genes identified by genome-wide association studies" docx
... http://arthritis-research.com/content/12/2/401 Page of Table Candidate genes identified from rheumatoid arthritis genome- wide association studies Gene GeneID PMID Gene expression (up or down) Microarray ... and Korean population Arthritis Rheum 2009, 60:364-371 10 Gorlov IP, Gallick GE, Gorlova OY, Amos C, Logothetis CJ: GWAS meets microarray: are the results of genome wide association studies and ... determined by comparison between 112 rheumatoid arthritis patients and 45 healthy individuals Abbreviations GWAS, genome- wide association studies; RA, rheumatoid arthritis Competing interests This study...
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Model selection methods and their application in genome wide association studies
... in Genomewide Association Studies 72 5.1 Introduction to the multiple testing for genome- wide association studies 73 5.2 The generalized tournament screening cum EBIC approach for genomewide association ... methods and some feature selection methods incorporated into model selection are reviewed in Subsection 1.3.2 1.3.1 Feature selection methods in genome- wide association studies In genome- wide association ... the dimension P is large Such a problem has become especially prevalent in genome- wide association studies A genome- wide association study (GWAS) is a promising way to detect genetic variants responsible...
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Báo cáo y học: " Stress response regulators identified through genome-wide transcriptome analysis of the (p) ppGpp-dependent response in Rhizobium " docx
... transport and metabolism Carbohydrate transport and metabolism Cell motility Cell wall/membrane biogenesis Energy conversion and production Nucleotide transport and metabolism Intracellular tracking and ... in the wild type and rsh mutant during stationary phase The expression values in each row were standardized by subtraction of the mean and division by the standard deviation and hierarchically ... using UDP-glucose and glucose-6-phosphate Not only is trehalose an energy and carbon source, it also stabilizes and protects proteins and membranes from dehydration, oxidation and cold [64] Recently,...
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Báo cáo y học: "Genome-wide association studies in systemic lupus erythematosus: a perspective" docx
... JPA: Non-replication and inconsistency in the genome- wide association setting Hum Hered 2007, 64:203213 Neale BM, Purcell S: The positives, protocols and perils of genome- wide association Am J Med ... stratification in genome- wide association studies Nat Genet 2006, 38: 904-909 10 Li M, Li C, Guan W: Evaluation of coverage variation of SNP chips for genome- wide association studies Eur J Hum ... Fernando M, Zidovetzki R, Gaffney PM, Edberg JC, Rioux JD, Ojwang JO, James JA, Merrill JT, Gilkeson GS, Seldin MF, Yin H, Baechler EC, Li QZ, Wakeland EK, Bruner GR, et al.: Genome- wide association...
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GENOME WIDE ASSOCIATION STUDIES OF CORONARY ARTERY DISEASE IN SINGAPOREAN CHINESE POPULATIONS
... lipid traits and myocardial infarction 92 Figure 11 Summary of genome wide association analysis of HDL-C The Manhattan plot summarizes the genotyped and imputed genome wide association ... on a genome wide scale Therefore, association analysis provides a much more effective way to unveil the genetic basis of CAD 2.3 Genome wide association studies of coronary artery disease and ... CAD Genome wide association analysis, which is a powerful tool to identify genetic variants, is commonly employed to identify novel genetic variants currently Most genome wide association studies...
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Báo cáo y học: " Restriction Site Tiling Analysis: accurate discovery and quantitative genotyping of genome-wide polymorphisms using nucleotide arrays" pptx
... is a need for and keen interest in generating genome- wide genotype data for wild populations of a species RSTA provides such quantitative genome- wide genotype data in a technically and analytically ... populations and HS is the mean of heterozygosity within populations [52] The genome- wide mean FST was 0.0029 among populations, with single locus FST values ranging from to 0.5 Genome- wide population ... analytically straightforward approach and without an upfront microarray design cost Opportunities for expanded genome- wide population genetics We present an accurate genome scanning method that allows...
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Báo cáo y học: "Meta-analysis of genome-wide linkage studies of asthma and related traits" potx
... skin tests) AND linkage AND genome- scan OR scan OR genome OR genomewide OR genome- wide OR LOD OR microsatellite) Limits were set on the search including; published in English, human studies, published ... published 1996–2006 and the exclusion of reviews This initial search identified 516 matches of which 488 were discarded as not containing genome- wide linkage data A further eight studies were discarded ... evidence for genome wide significance for linkage and a p < 0.0083 provides suggestive evidence for linkage [5] Results Data included The selection criteria and data requests provided eleven studies...
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Báo cáo y học: "Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells" pptx
... DEP5 and DEP25, DEP and 25 μg/ml, respectively; ox10, ox20, ox40: ox-PAPC 10, 20 and 40 μg/ml, respectively; DEP5 + (ox10, ox20 ox40): DEP μg/ml + ox-PAPC 10, 20 and 40 μg/ml respectively Genome ... polycyclic aromatic hydrocarbons and quinones), transition metals, sulfates and nitrates In studies looking at the effects of diesel exhaust particles (DEP) on the lung, we and others have shown that ... treated HMEC with ox-PAPC at concentrations of 10, 20, and 40 μg/ml; DEP at Genome Biology 2007, 8:R149 http://genomebiology.com/2007/8/7/R149 Genome Biology 2007, (a) Volume 8, Issue 7, Article...
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Báo cáo y học: "Novel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling" ppt
... mouse and human pDCs cluster together and apart from cDCs (Figure 3) Importantly, when analyzing the DC datasets alone, mouse CD8α and human BDCA3 cDCs on the one hand, and mouse CD11b and human ... decomposition for genome- wide expression data processing and modeling Genome Biology 2008, 9:R17 http://genomebiology.com/2008/9/1/R17 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 Genome ... http://genomebiology.com/2008/9/1/R17 Genome Biology 2008, value, and 'absent' and 'present' calls Target intensity was set to 100 for all chips membership indexes, each comprised between and [34]...
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Efficient computational techniques for tag SNP selection, epistasis analysis, and genome wide association study
... Introduction 1.1 1.1.1 Motivation Genome- wide association studies (GWAS) A genome- wide association study (GWAS) searches for inherent expression (genetic patterns) from a genome that is potentially ... of genome- wide association studies He guided me in developing ideas rigorously and logically through our regular meetings over the past four years I especially appreciate his encouragement and ... classification tasks and has been successfully applied to the identification of genome- wide associations in casecontrol studies RF can also be applied to population association studies with multivariate...
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A population based study of copy number variations and regions of homozygosity in singapore and swedish populations using genome wide SNP genotyping arrays
... Chia KS The pursuit of genome- wide association studies: where are we now? Journal of Human Genetics 55: 195-206 (2010) 15 Ku CS*, Chia KS The success of the genome- wide association approach: a ... Kee-Seng Whole Genome Resequencing and 1000 Genomes Project Published online: 19 April, 2010 Chee Seng Ku, Nasheen Naidoo, Mikael Hartman, Yudi Pawitan Genome wide association studies of cancers ... Published Genome- Wide Association Studies: http://www .genome. gov/26525384) Almost all the GWAS have used the commercially available whole -genome SNP genotyping arrays from Illumina and Affymetrix...
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TDT for human QTL mapping and genome wide association study
... 50 CONTENTS v TDT in Genome- wide Association Study 57 4.1 FDR-controlling procedure 58 4.2 Genome- wide TDT procedure using logistic model and feature selection techniques ... has not been applied to genome- wide association study yet In this thesis, we provide an efficient logistic model and an algorithm to search the causal genes in the genome- wide scope This algorithm ... 4.2.1 4.2.2 LASSO and glmpath 64 4.2.3 Genome- wide mapping procedure 67 4.2.4 4.3 Introduction to logistic model for TDT 62 Genome- wide TDT for...
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A genome wide association study of pulmonary tuberculosis susceptibility in Indonesians doc
... manuscript TO and MS were the principal investigators of the study, and supervised it throughout together with RC and MH BA, ES, RN all played crucial roles in patient and control selection and sampling ... Petersburg and Samara, Russia, and Cambridge, UK, and had written informed consent from all participating subjects Genotyping Stage 1: GWAS in Indonesian cohort For the initial genome- wide scan, ... S2: Association results and genotype counts of nine significant SNPs from the combined meta-analysis results of all three stages List of abbreviations TB: tuberculosis; GWAS: genome wide association...
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Báo cáo y học: "Identification of novel genetic susceptibility loci for Behçet''''s disease using a genome-wide association study" pps
... KIAA1529, CPVL, LOC100129342, and UBASH3B A probable association with UBAC2 was also identified We performed a genome- wide association study and identified novel candidate genetic loci that confer ... total of 152 patients were included in this study We have identified 10 possible candidate genes based on the unbiased genome- wide pooling association study Individual case-control genotyping using ... incompletely understood We have performed a genome- wide genetic association study using a cohort of Turkish Behçet's disease patients and controls We identified novel genetic susceptibility loci...
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báo cáo khoa học: " The public health utility of genome-wide association study results for smoking behavior" docx
... GR: Genomewide association for nicotine dependence and smoking cessation success in NIH research volunteers Mol Med 2009, 15:21-27 Guessous I, Gwinn M, Khoury MJ: Genome- wide association studies ... CL and PFS were involved in drafting the manuscript and have reviewed and approved the final version Acknowledgements We thank Jennifer Dackor for her curation of the genome- wide association studies ... co-morbidity between nicotine dependence and other substance abuse conditions and psychiatric dis orders, the possibility of pleiotropic associations and the differential prevalence of risk-conferring...
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báo cáo khoa học: "Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data" ppt
... for multiple sclerosis identified by a genomewide study N Engl J Med 2007, 357:851-862 12 Australian and New Zealand Multiple Sclerosis Genetics Consortium: Genome- wide association study identifies ... (CD58, CD226, SELPLG, and VCAM1) and MHC class I and class II genes Wang et al Genome Medicine 2011, 3:3 http://genomemedicine.com/content/3/1/3 Page of 11 Table Clinical and demographic characteristics ... HLA-DRB1 and 11 additional validated susceptibility genes bThe 350-gene set includes HLA-DRB1 and 349 additional genes identified in the genetic profile Wang et al Genome Medicine 2011, 3:3 http://genomemedicine.com/content/3/1/3...
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Genome wide association study for reproduction traits in maternal pig breeds
... 2: A Genome- Wide Association Study in Large White and Landrace pig populations for number piglets born alive 59 IV Contents Chapter 3: Genome- Wide Association Study in Large White and Landrace ... chromosome -wide and genome- wide SNPs found within and across breed × organisation data set depending on trait and breed 130 Table 12: Number of identified chromosome- and genome- wide significant ... QTLs and associations for NBA and components traits were identified on SSC13 (N = 58) and on SSC1 (N = 40) The lowest amount of QTLs and associations were identified on SSC5 and 11 (N = and 6,...
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Báo cáo khoa học: Genome-wide analysis of clustering patterns and flanking characteristics for plant microRNA genes doc
... improve the current understanding of transcriptional regulation and processing of plant miRNAs and provide useful knowledge for understanding the mechanism of the origin and computational identification ... miRNAs in plants, and these were limited to A thaliana and O sativa Recently, increasing numbers of plant miRNAs have been identified through forward genetics, direct cloning and computational ... gene pairs with random distances, as described in the Materials and methods, and found that the miRNA gene pair distances were statistically significantly higher than expected at random (P < 0.001)...
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Báo cáo y học: "Genome-wide prioritization of disease genes and identification of disease-disease associations from an integrated human functional linkage network" pps
... On the other hand, the remaining data sources are relatively unbiased, and include sequence data, high-throughput experiments, and functional associations mapped from yeast, worm, and fly (organisms ... disease genes and are identified by both methods (pairs connected by blue links in Figure 8a) However, the remaining 49 pairs share no known disease genes, and their associations are identified ... and for details) (2) i =1 Genome Biology 2009, 10:R91 http://genomebiology.com/2009/10/9/R91 Genome Biology 2009, Neighborhood-weighting decision rule ground gene set within each test case, and...
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