... aspects of studydesign, performance, and analysis, with a focus on randomization of the study sub-jects, blinding of the investigators and study subjects, and the handling of dropouts and withdrawal ... perforatum L.)Hypericum, an extract of the flower of St. John’s wort, has been used for the treat-ment of depression for centuries (Mischoulon, 2007). St. John’s wort is the commonname for the ... 2004), it is not known whether digoxin will remain as the standard therapy for heart failure (Hauptman and Kelly, 1999).In the future, there might be other uses for digitoxin. There is evidence that...