... Ophthalmol Scand 2004, 82 :11 5 -11 7 Klocek MS, Sassani JW, McLaughlin PJ, Zagon IS: Naltrexone and insulin are independently effective but not additive in accelerating corneal epithelial healing intype ... epithelial and endothelial cells and thus result in cellular dysfunction [3,4] This results in delayed healing responses and loss of epithelial adhesion to the basement membrane, increasing the risk of ... local diabetes clinic At a one-month review inthe eye clinic, her ulcer remained healed, leaving a localized area of subepithelial scarring (Figure 4) Discussion The ocular features of diabetes...
... studied the conformation of cyclo17, 21[ Asp17,Lys 21] hCt (16 –22)-NH2 (1a), cyclo17, 21- [Asp17, D-Phe19,Lys 21] hCt (16 –22)-NH2 (2a), cyclo17, 21- [Asp17, Aib19, Lys 21] hCt (16 –22)-NH2 (3a), and [Asp17,Lys 21] ... of a type II¢stabilized analogue of would offer direct information about theroleofthe topographical features ofthe side chains ofthe residues in region 17 – 21 for receptor binding andin vivo ... these studies demonstrated the crucial roleof residues 18 and 19 and their chirality for human receptor binding Moreover, these findings suggested that the side chains of residues 18 and 19 and/ or...
... theroleof HIF -1 in chondrocytic energy generation, matrix synthesis and cell survival During hypoxic and normoxic conditions, functional inactivation of HIF -1 inthe presence of interleukin -1 ... Acknowledgements This work was supported in part by the Ministry of Research (IZKF-Erlangen, C2) andthe Deutsche Forschungsgemeinschaft (PF383/4 -1) References 10 11 12 13 14 15 Yudoh K, Nakamura H, Masuko-Hongo ... Sci 2003, 11 6 :18 19 -18 26 Lin C, McGough RM, Aswad B, Block JA, Terek R: Hypoxia induces HIF-1a and VEGF expression in chondrosarcoma cells and chondrocytes J Orthop Res 2004, 22 :11 75 -11 81 Coimbra...
... 12 9 4.2 Expression of caspase -1 and growth of virus in influenza A/PR/8/34 (H1N1) infection of RAW264.7 macrophages 13 0 4.3 Insights into theroleof caspase -1 using a murine ... 19 18 H1N1 “Spanish Flu”, the 19 57 H2N2 Asian Flu, the 19 68 H3N2 Hong Kong Flu andthe most recent Mexico swine-origin influenza A/H1N1 (2009) Of these 4, the infamous 19 18 “Spanish Flu” pandemic ... components ofthe inflammasome initiate the processing of procaspase -1, resulting inthe formation ofthe active caspase -1 Active caspase -1 processes the IL -1 precursor (step 7) inthe cytosol...
... Gregg EW, Bainbridge KE, Saydah SH, Geiss LS: Full accounting ofdiabetesand pre -diabetes inthe U.S population in 19 88 -19 94 and 2005-2006 Diabetes Care 2009, 32:287-294 doi: 10 .11 86/cc 910 1 Cite ... resistance and dysfunction of beta cells Insulin resistance is present inthe acutely ill [13 ,15 ,18 ,28] in different intensity, but the factors determining the extent of insulin resistance are not ... insulin resistance by inducing the release of stress hormones They also alter insulin receptor signalling [12 -16 ] and create insulin resistance Due to these actions, glucose uptake in fat and...
... HIV -1 subtype C chimeras in U373-MAGI-CCR5 and U373-MAGI-CXCR4 cell lines MAGI-CCR5 Infection counts → 5000 CHIMERA_ 17 1 17 3 18 2 18 3 221A 282 284 3 31 334 452 512 514 639 10 11 1 014 2099 (B-R5) 210 1 ... 210 1 (B-X4/R5) 30 41 (C-R5) 54 41 (C-X4) MAGI-CXCR4 10 000 5000 No of blue cells 21 23 9 13 23 1 11 16 - 10 000 Phenotype from MT-2 No of blue cells 99 92 18 12 30 31 65 26 33 19 10 34 - 10 23 21 ... AP.33/3 31, 334 AP.4/452, 454 AP.5/ 512 , 514 AP.6/639 AP .10 /10 11, 10 14 A score of -6.96 was used as a cut off for R5 strains and a score of -2.88 was used as a cutoff for X4 strains Most of these...
... HIV -1 subtype C chimeras in U373-MAGI-CCR5 and U373-MAGI-CXCR4 cell lines MAGI-CCR5 Infection counts → 5000 CHIMERA_ 17 1 17 3 18 2 18 3 221A 282 284 3 31 334 452 512 514 639 10 11 1 014 2099 (B-R5) 210 1 ... 210 1 (B-X4/R5) 30 41 (C-R5) 54 41 (C-X4) MAGI-CXCR4 10 000 5000 No of blue cells 21 23 9 13 23 1 11 16 - 10 000 Phenotype from MT-2 No of blue cells 99 92 18 12 30 31 65 26 33 19 10 34 - 10 23 21 ... AP.33/3 31, 334 AP.4/452, 454 AP.5/ 512 , 514 AP.6/639 AP .10 /10 11, 10 14 A score of -6.96 was used as a cut off for R5 strains and a score of -2.88 was used as a cutoff for X4 strains Most of these...
... Sensitivity 17 7 Kevin C Maki and Tia M Rains Part Complications 19 1 Chapter 10 Characteristics of Vitamin B12 Deficiency in Adult Chinese Patients with TypeDiabetesandthe Implication of Metformin 19 3 ... (2 011 ) Prevalence of Prediabetes in School-Going Children, Indian Pediatrics, Vol 48, 2 011 , pp 295-299, ISSN 0 019 -60 61 NDS (2 011 ) National Diabetes Statistics, 2 011 , U.S Department of Health and ... appear to be the only region involved in fibril formation In fact, recent studies have evidenced the importance ofthe residues in position 13 -18 inthe interaction leading to the formation of fibrils...
... resistance /type diabetes Thus, lipids inthe liver link typediabetes to increased secretion of VLDL1 Another factor of importance is insulin Although insulin inhibits the assembly of VLDL1 in individuals ... forthe formation of lipoproteins It exists in two forms: apoB48 on chylomicrons (the lipoproteins formed inthe intestine); and apoB100 on very low-density lipoproteins (VLDL; the lipoproteins ... determinant forthe secretion of VLDL1 is the amount of triglycerides inthe liver An accumulation of ectopic triglycerides inthe liver is a major event inthe development of insulin resistance/type...
... 0.02 cm2 inthe UA, 0 .18 ± 0.04 cm2 inthe TA, and 0.05 ± 0. 01 cm2 inthe SA The CSAs inthe controls were 0.08 ± 0.02 cm2 inthe MA, 0.07 ± 0.02 cm2 inthe MB, 0.04 ± 0. 01 cm2 inthe UA, 0 .10 ± ... next to the hand inthe somatotopic map and by anaesthetizing the forearm, the cortical hand area can rapidly expand over the forearm area resulted in improved sensory function ofthe hand in healthy ... between typediabetesand an increased risk for certain types of cancer affecting the gastrointestinal tract Kamoi summarizes evidence supporting therolefor high blood pressure and techniques for...
... clarify whether sigma -1 receptors are involved inthe active mechanism of fluvoxamine To confirm theroleof sigma -1 receptor agonism inthe treatment of psychotic Table 1: Characteristics and depression ... should be performed to clarify theroleof sigma -1 receptors inthe efficacy of fluvoxamine for psychotic depression Consent Written informed consents were obtained from the all patients in this case ... fluvoxamine (50 to 200 mg), but not paroxetine (20 mg), binds to sigma -1 receptors inthe intact human brain at therapeutic doses [5], suggesting that sigma -1 receptors are involved inthe active...
... the phenotype of cells within the IVDs in vivo, the cell phenotype was assessed in monolayer culture and at increasing times in alginate culture The phenotype was then compared with that of uncultured, ... proportions of cells inthe NP and IAF reacting for IL -1 , IL-1Ra, and ICE (P = 1. 525, 0.870, and 0.639, respectively) IL -1 and IL-1RI immunopositive cells were more frequent inthe NP than the IAF ... immunoreactivity for any ofthe five molecules inthe OAF; low proportions of cells immunopositive for IL -1 , IL1β, and IL-1RI inthe NP and IAF (approximately 20%); the presence of IL-1Ra immunopositive...
... 8,879.37 11 ,12 1.66 1. 25 He et al Journal of Biomedical Science 2 011 , 18 :22 http://www.jbiomedsci.com/content /18 /1/ 22 Page of 10 Figure Regulation of miR -1 and miR -13 3a by IPost MiR -1 and miR -13 3a ... rno-miR -1, NR 03 211 6 .1; rno-mir -13 3a, NR 0 318 79 .1) and AMOs (AMO -1 and AMO -13 3a) were synthesized by Jima Inc (Shanghai, China) The sequences of miRNA mimics and AMOs are showed in Table Mimic and ... angiopoietin-2 andthe Tie2 receptor but not angiopoietin -1 or the Tie1 receptor in a rat model of myocardial infarction J Biomed Sci 2004, 11 :16 3 -17 1 Yin C, Salloum FN, Kukreja RC: A novelroleof microrna...
... FR139 317 or PD 14 5065 Br J Pharmacol 19 94, 11 1(4) :10 09 -10 16 Henry PJ, Carr MJ, Goldie RG, Jeng AY: Theroleof endothelin in mediating virus-induced changes in endothelinB receptor density in ... Grants 10 5828 /1 and 67865.02, the Lancardis Foundation and Hungarian Scientific Research Grant OTKA F38340 23 References 24 10 11 12 13 14 15 16 17 18 19 20 21 Carvalho CR, de Paula Pinto Schettino ... potential, ET -1 compromises the lung mechanics [7 ,11 ,14 ,18 ] and it may therefore play a roleinthe regulation ofthe airway tone Separate assessment ofthe airway and tissue responses to ET -1 in mice...
... bipartite NLS (18 6KRK and 211 KELQKQITK) by showing that IN mutants K186Q and Q 214 / 216 L in these regions lost the protein nuclear localization and their inability to bind to karyopherin α in vitro [3] ... C and sequence Q [17 ] inthe C-terminal domain of HIV -1 IN, impaired protein nuclear localization, while mutations of arginines at amino acid position of 263 and 264 inthe distal part ofthe ... feature of HIV -1 IN To delineate the karyophilic determinant in HIV -1 IN, two truncated IN- YFP expressors CMV -IN5 0–288-YFP and CMVIN1– 212 -YFP were generated In CMV -IN5 0–288-YFP, the Nterminal HH-CC...