... G1[ 19] . In particular, p21 is a direct target of SREBP [20]. The role of SREBP-1a in the regulation of cell growth and the cell cycle might be biphasic and complex, and needs to be further investigated.SREBP ... b-cellmass is crucial in the development of diabetes.SREBP-1c inhibition of IRS-2 affects b-cell mass and promotes diabetes. Besides affecting b-cell mass, the other factors by which SREBP-1c ... blockbinding of COPII proteins to SCAP, thereby controllingSCAP sorting in ER. Proc Natl Acad Sci USA 99 ,11 694 –11 699 .5 Horton JD & Shimomura I ( 199 9) Sterol regulatory ele-ment-binding proteins:...