... suggestion [10,13]. Knee instability is verylikely to increase inappropriate mechanical loading in manyparts of the joint and, in keeping with this, col II and YKL40expression rose in all locations ... progression characterized by further upregulation of MMP13 and tenascinC. From a clinical point of view, the possibility of differentiating successive stages of OA pro-gression by means of early and ... chondrocytes in human OA, and in a similar direction.Conclusion In conclusion, upregulation of col II, col I and YKL40 was avery sensitive and robust response to the alteredmechanical situation after...