Báo cáo y học: "Uric acid is a strong independent predictor of renal dysfunction in patients with rheumatoid arthritis" docx
Báo cáo y học: "Uric acid is a strong independent predictor of renal dysfunction in patients with rheumatoid arthritis" docx
... draftedthe manuscript and participated in data acquisition. VP partic-ipated in data acquisition, provided technical assistance andassisted in analysis and interpretation of data. TT, HJ and IAparticipated ... Kubo M, Kiyohara Y, Kato I, Iwamoto H, Nakayama K, Hirakata H,Fujishima M: Effect of hyperinsulinemia on renal function in a general Japanese population: the Hisayama study. Kidney Int1999, ... hyperuricaemia [20,45].Apart from a direct pathogenic association of UA with renal dysfunction, alternative explanations may also apply. To start with, UA may just be 'marking' patients...
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Báo cáo y học: "Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren''''s syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate" pptx
... K, Tagawa Y, Iwakura Y, KayagakiN, Kurimoto M, Okamura H, Hada T, Yagita H, Akira S, NakanishiK, Higashino K: IL-18 up-regulates perforin-mediated NK activ-ity without increasing perforin messenger ... expression of IL-18 by CD68+ macrophages wasobserved only within periductal inflammatory foci and in periacinar macrophages adjacent to focal infiltrates, andnot in isolated macrophages, an observation ... at somelevel was detected in all SS patients studied, but interest-ingly only in a minority of patients with chronic sialoadenitis.No staining for IL-18 was found in acinar cells, indicatingthat...
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Báo cáo Y học: Bass hepcidin is a novel antimicrobial peptide induced by bacterial challenge pptx
... 90) is probably the translational start sitebecause it is followed by a typical signal peptide motif with a basic residue (lysine) and a hydrophobic region (rich in valine and alanine) and matches ... acids) consists of three domains: a signal peptide (24 amino acids), prodomain (40 amino acids)andamaturepeptide(21aminoacids).Thegenehastwointrons and three exons. A TATA box and several consen-sus-binding ... gills may have a mechanism to bind or concentrate bass hepcidin. In summary, bass hepcidin, a homologue of humanhepcidin, was isolated from the gills, demonstrates antibac-terial activity against...
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Báo cáo Y học: Arginine 121 is a crucial residue for the specific cytotoxic activity of the ribotoxin a-sarcin potx
... of RNase T1 [23,26,27] and His50 of a- sarcin [20] areinvolved in catalysis rather than in substrate binding. Therole of Arg77 has not yet been established as all attempts toisolate any RNase ... quantitative analysis of the ribonucleaseactivity of a- sarcin has been developed by using thedinucleotide ApA as substrate [18]. Both mutant variantshydrolysed ApA. They displayed a Kmvalue ... composing the spot obtained with a photodocumentation system UVI-Tec using the software facilityUVISOFT UVI BAND) vs. protein concentration (determinedby amino -acid analysis of acid- hydrolysed...
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Báo cáo y học: "The human anti-IL-1β monoclonal antibody ACZ885 is effective in joint inflammation models in mice and in a proof-of-concept study in patients with rheumatoid arthritis" doc
... activity.Proof -of- concept clinical trial in patients with RA A proof -of- concept study to explore safety and tolerability,pharmacokinetics and pharmacodynamics was conducted in patients with established ... evaluate the safety and tolerability of ACZ885 adminis-tered as an intravenous infusion. Secondary objectivesincluded assessment of the preliminary biologic activity/phar-macodynamics of ACZ885 ... tolerability and pharmacodynamic activity of ACZ885 in RA patients in a small proof -of- concept study – the first to beconducted in humans. Patients with active RA despite treatment with stable...
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Báo cáo y học: "SAPHO syndrome: Is a range of pathogen-associated rheumatic diseases extended" ppsx
... Massara A, Cavazzini PL, Trotta F: In SAPHO syndrome anti-TNF-alpha therapy may induce persistent amelioration of osteoarticular complaints, but may exacerbate cutaneousmanifestations. Rheumatology ... This is a significant addition to a longrange of publications showing an association of SAPHO with P. acnes in 42% of patients (Table 1). The activity of SAPHO,by assessment of skin disease, ... beenEditorialSAPHO syndrome: Is a range of pathogen-associated rheumaticdiseases extended?Alexander P RozinB. Shine Department of Rheumatology, Rambam Health Care Campus and Rappaport Faculty of Medicine,...
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Báo cáo y học: "The past is a foreign country" docx
... own lab.• ey have almost certainly never seen anyone blowglass. In fact, many of them may not know that test tubes were ever made of anything but plastic.• ey have always had ... In theirlifetime,noonehaseverpipettedanythingbymouth.• DNAsequencing,peptidesynthesis,chemicalanalysis,and gene synthesis have always been farmed out to specialty companies rather than done in one’s ... have largely been seen as incompatible.• ere have always been ‘big science’ projects in biology.• Chemistryhasalwaysbeen a decliningeld in terms of student interest, and physics...
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Báo cáo y học: "Aboriginal status is a prognostic factor for mortality among antiretroviral naïve HIV-positive individuals first initiating HAART" ppt
... were diag-nosed with AIDS during the HAART era, declines in deathswere smaller among racial minorities (black, Hispanic,Asian/Pacific Islanders, American Indian/Alaskan Native)compared with ... health care disparities exist bydetermining what other aspects of being Aboriginalincrease their risk of mortality after initiating HAART canprovide potential targets for intervention in this ... aboriginalstatus, clinical and socio-demographic confounders with time to death are displayed in Table 4. Aboriginal statuswas strongly associated with mortality in both univariate(hazard ratio...
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Tài liệu Báo cáo Y học: Dinucleoside polyphosphates stimulate the primer independent synthesis of poly(A) catalyzed by yeast poly(A) polymerase ppt
... poly (A) catalyzed by yeast poly (A) polymerase. The relativeactivity of diadenosine polyphosphates as effectors of the poly (A) synthesis was assayed as in Fig. 4, using0.05 mM [a- 32P]ATP as substrate, ... strain containing a clone of the yeast poly (A) polymerase gene [6]. In principle, it can be assumed that thispreparation corresponds to pure poly (A) polymerase with no contaminating cleaving factors.While ... properties of yeast poly (A) polymerase and on the intracellular role of dinucleosidepolyphosphates, a family of compounds of increasingmetabolic and regulatory interest [7–11].MATERIALS AND METHODSMaterialsPoly (A) ...
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Báo cáo y học: "DAS28: a useful instrument to monitor infliximab treatment in patients with rheumatoid arthritis" pps
... opinion-based, approach, with expertrating (n = 35) of a sample of clinical profiles that werecategorised into remission, low disease activity, moderatedisease activity and high disease activity [7]. Interestingly, ... external criteria for high and low disease activityto study the validity of the Disease Activity Score and theDAS28. In a study performed in Italy in the late 1990s, it wasfound that the Disease ... with absolute values to measuredisease activity in daily clinical practice and clinical trials.ConclusionThe study of Vander Cruyssen and colleagues confirms thatthe DAS28 is a valid measure...
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