... [1-3] However, theclinical significance of RBM thickening, and the mechanisms involved in its pathogenesis remain unclear In particular, it is not known at what age RBM thickening begins RBM thickness ... timing and natural history of RBM thickening, and other features ofairway remodelling in children, would be increased by the development of non-invasive techniques, thus providing the opportunity ... time and in response to treatment A number of non-invasive techniques have been developed for the study ofairway inflammation inasthma [4] In comparison, there has been little interest inthe development...
... findings within existing literature The weakest section of reporting across studies was planning ofthe interventions, with less than half of studies including any ofthe five elements outlined ... case discussion between distant health professionals 12 12.1 Organisational interventions Provider oriented Revision of professional roles 11 11.1 Satisfaction of providers withthe conditions of ... interventions in their initiatives; thus, it was difficult to make judgements regarding the unique or combined contribution of selected interventions on positive outcomes Furthermore, within the studies there...
... selecting the insertion site, the risk profile ofthe individual patient should be evaluated Subclavian access is preferable when the risk for infection is high Because the risk for infection increases ... approaches With CVCs only, we found that thrombosis ofthe internal jugular vein was diagnosed far more often than thrombosis ofthe subclavian vein (RR 4.13) [12] Haemodialysis catheter insertion is ... associated with an increased risk for venous thrombosis and subsequent stenosis [13] When manoeuvred around the bend at the innominate–caval junction, the tip ofthe catheter or its introducer...
... (16, 17) In older children, the type of pain is often a function oftheclinical stage ofthe infection In early HIV, most pain occurs as a result of opportunistic conditions and is, therefore, ... antidepressants ofthe class of serotonin and norepinephrine reuptake inhibitors for persisting neuropathic pain inchildren > 10 • Gabapentin for persisting neuropathic pain inchildren • Ketamine as ... Mucositis after chemotherapy or radiotherapy is also a frequent cause of pain inchildrenwith cancer > 24 Causes of persisting pain inchildrenwith cancer Chronic pain can be either caused by the...
... the manuscript JMG participated inthe design ofthe study and revised the manuscript POB participated inthe design ofthe study and revised the manuscript CS participated inthe design ofthe ... reviewed the statistical analysis and revised the manuscript UAL participated inthe design ofthe study and revised the manuscript TR participated inthe design ofthe study and revised the manuscript ... calculating the extent of missing items within each HRQL instrument The analysis of measurement properties requiring a longitudinal assessment were beyond the scope of this study The SAPALDIA...
... withasthma within the context of other predictors With this study a first step is made in investigating predictors of HRQoL while taking other predictors in account Since most studies investigate ... aim ofthe present study was to further explore predictors of HRQoL ofchildrenwithasthma This study is, to our knowledge, the first study that investigated predictors of HRQoL inchildrenwith ... functioning However, interrelations between the different factors inthe prediction of HRQoL remained unclear The aim of our study is to further explore predictors of HRQoL withthe stress-coping...
... nitrogen)-0.170 × (albumin)+0.318 × (0.762 if the person is female), since there were no differences inthe pattern of significance of findings arising from the full data analysis based on any ofthe three ... function during the 12 months of therapy compared with controls [41] On the other hand, in a cohort of patients with chronic kidney disease treated with allopurinol, discontinuation of allopurinol led ... might be the link between CVD and renal dysfunction in patients with RA To thebestof our knowledge, this isthe first study that focuses on the role of UA in renal dysfunction in patients with...
... to difficulty with walking in about 75% of people with RA, and isthe main or only cause of walking difficulty in 25% [1] Inthe foot, joint pain and stiffness isthe most common initial presentation, ... of mobility 42% of RA patients are registered disabled within yrs of diagnosis [2] 80% are moderately to severely disabled within 20 yrs At diagnosis, 16% of RA patients may have foot joint involvement ... mechanism should be in place whereby everyone with a diagnosis of inflammatory arthritis receives a foot examination within three months of diagnosis [16] Patients with RA should be provided with information...
... of BP that were the focus of our workshop and are the focus of this commentary The rate of BP diagnoses is rising faster inthe US than elsewhere Though debates about the diagnosis of BP inchildren ... conceptualizations ofthe disorder, in combination with other social and clinical factors, have fueled a significant increase inthe number ofchildren diagnosed with and treated for BP Insofar as everyone ... below the diagnostic rates ofthe US (Brazil, where 7.2% oftheclinical population is diagnosed with BP [39], isthe only country with diagnostic rates close to the low end ofthe estimates for the...
... insulin isoforms at the level of both transcription and translation This leads to an increase inthe ratio of insulin I over insulin II in terms of both their respective mRNA content as well as their ... understanding when I was preparing the final draft of my thesis I thank the Lord for giving me good health and strength to finish this PhD dissertation for without his grace nothing is possible ... the treatment of diabetes It is a competitive inhibitor ofthe major α-glucosidase enzymes inthe brush border ofthe mucosal cell ofthe small intestine It inhibits the digestion ofthe complex...
... origin Davenport et al [14] interpreted their findings within the frame ofthe blunted perception of inspiratory load that has been observed in asthmatic patients with a history of life-threatening ... [15] Statistical analysis Right-to-left comparisons ofthe presence ofthe various components ofthe RREPs were conducted within the controls and within each category of patients using the McNemar ... respiratory inflammation may interfere withthe processing of respiratory afferent information by the brain, whatever the underlying mechanism Indeed the number of CF patients exhibiting no RREP...
... methacholine (PC20 ≤ 12.5 mg/ml) Childrenwith severe asthma or other clinically significant medical conditions were excluded Ofthe 1041 children enrolled inthe original clinical trial, 968 children ... population is a genetic isolate of mixed Spanish and Amerindian descent with one ofthe world’s highest rates ofasthma (27.4% ofchildren aged 6-7 years [25]) Questionnaires were sent to the parents of ... excluded from this analysis because of Mendelian inconsistencies, leaving 586 trios Ofthe 422 nuclear families in CAMP trios, 25 were excluded from this analysis because of Mendelian inconsistencies...
... effects of combining these medications would be premature, and the present findings can be applied only to childrenwith an inadequate stimulant response Nonetheless, the findings ofthe present ... atomoxetine each have been established as an effective monotherapy for the treatment of ADHD, a number ofclinical situations may arise that would suggest the strategy of augmenting or combining the ... tolerability findings from this study mirror previous findings of cardiovascular effects in patients who have received combined treatment as a portion of a clinical trial design In a study optimizing the...
... stability of sleep problems over time in this group ofchildrenThe increased rate of sleep problems inchildrenwith chronic illness may have several potential pathways, some of them suggesting a ... problems In addi- There are several potential factors that may explain the increased persistency of sleep problems inthe chronic illness group Having a neurological disorder greatly increased the risk ... schools inthe city of Bergen, Norway The protocol and population ofthe BCS is described in detail elsewhere [8,12] In short, inthe first wave, the target population was 9430 primary school children...
... management of incidental findings in research studies has not been raised in musculoskeletal imaging It is important given the increasing use of MRI inthe investigation of OA by researchers trained ... radiologist or other suitably trained specialist review all the images or just the baseline images in a longitudinal study This will also add to the cost ofthe research study Despite the increasing ... [7,8] This issue has prompted institutions to institute formal plans to deal withthe ongoing management of these incidental lesions at many levels, incorporating clinical, ethical, and financial...
... will find answers," the old man said "One is within yourself The other isin these blogs For now, you have no answers within yourself, so we must start by observing these blogs For the rest ofthe ... heavily influenced by The Zen of Juggling by Dave Finnigan Additional inspiration came from The Matrix by The Wachowski Brothers, The Lord ofthe Rings by J R R Tolkien, The Legend of Zelda by Nintendo, ... domain name," the old man said "While the words don't make sense, they have a nice ring to them They roll off the tongue and flow withthe blog." "I see And what about this one? This one is long,...
... paradigm where a predefined level of demand is managed internally and the remainder augmented with cloud services The apothegm is ‘Own the base and rent the peak’ Conclusion The customer’s overall ... starts with an assessment of value The assessment of value of cloud services can only include a comparison against other cloud providers The comparison of cost between traditional IT investment ... deal? Ordering IT Services: Would you like CHIPS with that? Sourcing's Three Fates The IT Outsourcing RFP COW is too FAT AMS - The next stage inthe evolution of IT Outsourcing Outsourcing’s Two...
... by smoking, drinking, exercising and the body mass index - contribute to explaining the gradient The size of this contribution is larger when we consider the entire history of behaviors rather ... three binary indicators: whether the mother died early, whether the father died early and whether the mother and the father where present when the individual was aged 10 The extracted principal ... the others are continuous We list below the synthetic indicators, the observed variables used for each indicator and the interpretation we propose, based on the sign ofthe scoring coefficients The...