... cardiomyopathy. Intern. Med. 34, 670–673.51. Wada, H., Woo, M., Nishio, H., Nagaki, S., Yanagawa, H.,Imamura, A. , Yokoyama, S., Ohbayashi, C., Matsuo, M., Itoh,H. & Nakamura, H. (1996) Vascular ... 774–779.48. Yoneda, M., Chomyn, A. , Martinuzzi, A. , Hurko, O. & Attardi,G. (1992) Marked replicative advantage of human mtDNA car-rying a point mutation that causes the MELAS encephalomyo-pathy. ... that the recyclingmechanisms are inherently imperfect [15,25], and this mayprovide an attractive explanation for many of the features of aging. A number of early explanations of aging, such as Orgel’s...