... insectcells,wereusedtodefinetheroleplayedbyeachtranscrip-tion factor and c oactivator in activation of the IFN-bpromoter. We s how that activation of the IFN-b promoterwas critically dependent on the nature of the ... H., Hata, N ., Asagiri, M., Ogasawara, K.,Nakao, K., Nakaya, T., Katsuki, M., Noguchi, S., Tanaka, N. &Taniguchi, T. (2000) Distinct and essential roles of transcriptionfactors IRF-3 and ... fragments. Moreover, we have shown that in the case of IRF-3, all of its interactions with the coactivators wereindispensable for transcriptional activity [21]. Similarly, wehave shown that the...