... 24 and 48 h of culture using trypan blue staining. (C) Cells weretreated with 0.5, 1 and 2 lg of hpST3dODN and 1 and 2 lg of control ODN for 6 h or with lipids only; after 48 h of culture, they ... (1988) Induction of indoleamine 2,3-dioxygenase: a mechanism of the anti-tumor activity of interferon gamma. Proc Natl Acad SciUSA 85, 1242–1246.41 Stephanou A (2004) Role of STAT-1 & STAT-3 ... be a good target for the induction of cell death. Several therapeutic approaches have beendeveloped to inhibit STAT3, including inhibition of itsexpression [14,15], inhibition of its dimerization...