... positions of molecular mass markers are shown to the left,and the size in base pairs of the products to the right (the Meis2 equivalent of Meis3.2 would be expected at 149 bp). (C, D) RNA from aseries ... However, the activity of the full-length Meis1awas not tested, and on the basis of our work we expectthat its activity would be inhibited by the conservedHth domain. The Meis1a isoform, in which the C-terminal ... independently of Pbx, and does notpossess the autoinhibitory function of the Hth domain.In summary, our data suggest that one function of the conserved Hth domain is to inhibit the activity of the transcriptional...