... because of animbalance in the activity of tau kinases and phospha-tases [3]. One particular tau kinase pertinent to metaldyshomeostasis in AD is glycogen synthase kinase-3(GSK3). GSK3 has ... a major component of the amyloid plaques in AD brain[42,43], global AD research focused on this peptide as a causative agent in the disease. The 39–43 amino acidcleavage product of the Ab A4 ... stress, a loss of regulation of Abproduction, and an increase in tau hyperphosphoryla-tion. Furthermore, an increase in extracellular metalscan catalyse Ab oligomerization and aggregation, andthe...