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Báo cáo y học: " A Novel Variable Number of Tandem Repeat of the Natriuretic Peptide Precursor B gene’s 5’-Flanking Region is Associated with Essential Hypertension among Japanese Females"
... region of the NPPB gene was discovered. This poly-morphism was associated with EH in female subjects. However, this finding does not necessarily imply that there is a relationship between the ... accession number AB265677). This VNTR polymorphism is a tandem repeat of the 4-nucleotide sequence TTTC (Fig. 1A). There were 8 alleles of this VNTR polymorphism, ranging from 9-repeat to ... a deletion of this gene develop disorders that resemble the symptoms of subjects with a deleted allele in the 5’-untranslated region of NPRA. We previously iso-lated a missense mutation of...
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Tài liệu Báo cáo khoa học: The splicing factor ASF/SF2 is associated with TIA-1-related/ TIA-1-containing ribonucleoproteic complexes and contributes to post-transcriptional repression of gene expression doc
... be associated with polysomes. Although the association of DDX21 with TIAR relies on RNA intermediate, DDX5, hnRNP Mand ASF ⁄ SF2 are associated with TIAR by protein–protein interaction. It is ... molecularprocesses. However, the physiological existence ofASF ⁄ SF2-TIA complexes is conditioned by the tissuedistribution of TIA protein [46], which is clearly morerestricted compared to ASF ⁄ ... acting synergisticallyfor optimal interaction with RNA, both RRMs mediateinteractions with distinct motifs present in mRNA mol-ecules addressed to SGs upon stress. ASF ⁄ SF2 is abona fide...
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Tài liệu Báo cáo khoa học: Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines docx
... HO-2expression with each of two different siRNAs is consis-tently associated with increased expression of HO-1mRNA and protein. Moreover, we provide evidencethat at least three mechanisms may account ... cells with HO-2 siRNA induced the expres-sion of HO-1 mRNA and protein without affectingthe concentration of GAPDH mRNA and b-actin(Fig. 4A,B). Likewise, the selective reduction of HO-2mRNA with ... underlined is an artificialHindIII site. A full-length HO-2 cDNA fragment was iso-lated from pCR-hHO-2-1 with EcoR1 and subcloned intothe pMACS4-IRES vector (Miltenyi Biotec Inc., Bergisch-Gladbach,...
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Báo cáo khoa học: Muramyl-dipeptide-induced mitochondrial proton leak in macrophages is associated with upregulation of uncoupling protein 2 and the production of reactive oxygen and reactive nitrogen species docx
... iden-tical to those of the unstimulated cells. This view is consistent with a previous report showing that MDP,but not a safe analogue such as MB, is capable ofinducing mitochondrial proton leak ... purinenucleotides [4]. UCP2 is widely expressed in many tis-sues with high levels detected in the spleen, thymus,pancreatic b-cells, heart, lung, white and brown adi-pose tissue, stomach, testis and macrophages, ... MDP. The question raised atthis stage is whether UCP2 is responsible for theincrease in mitochondrial proton permeability (state 4)induced in macrophages after stimulation with MDP.Purine nucleotides...
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Báo cáo khoa học: Cellular refractoriness to the heat-stable enterotoxin peptide is associated with alterations in levels of the differentially glycosylated forms of guanylyl cyclase C pdf
... long-termtreatment of cells with ST. As the 130 kDa form of GC-C is still on the surface after prolonged ST treatment, it is notclear at this time whether the 130 kDa form alone is recycled, or not ... cells with ST at 4 °Csuggest that down-regulation is brought about by selectiveinternalization of the 145 kDa form through endocytosisand subsequent degradation. The mechanisms involved inthis ... 20-day-oldCaco2 cells were washed with serum-free DMEM/F12 andincubated with or without 10)7MSThinDMEM/F12for9 h. Monolayers were then washed and re-stimulated with fresh STh (10)7M) in the...
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Báo cáo khoa học: N-Methylation in polylegionaminic acid is associated with the phase-variable epitope of Legionella pneumophila serogroup 1 lipopolysaccharide pptx
... stereoisomerism). The lower-đeld1H NMR signal of 3 belonged to the N-methyl group at N2in the E isomer and t he higher-đeld signal t o that in t heZ isomer, in which N1 is in trans and cis ... stereoisomers,E and Z, with regard to the partial double bond at N2, whilethe NMR spectra showed the presence of only one isomer.Molecular modelling data ( not shown) suggested t hat thisisomer ... an(N,N-dimethylacetimidoyl)amino group is presen t (Fig. 8,structure 2). This group is linked to C5 of a legionaminicacid residue, which is substituted with a nonmethylatedN-acetimidoyl group...
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Báo cáo khoa học: Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade pptx
... reported that bikunin expression is associated with a less malignant phenotype [24]. There is evidence that bikunin significantly prevented pulmonarymetastasis of mouse Lewis lung carcinoma 3LL cells ... sodium vanadate is associated with increased uPAR expression: bikunin hasno ability to inhibit overexpression of uPAR in cells treated with sodium vanadate, indicating that bikunin is able tosuppress ... analysis.(B) Unstimulated cells were treated with PD098059 (60 lM) or vehicle for 12 h. C, Cells were pretreated with staurosporin (50 nM), PD098059(60 lM), U0126 (20 lM), or with a...
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Báo cáo khoa học: The unique pharmacology of the scorpion a-like toxin Lqh3 is associated with its flexible C-tail pdf
... Whereas substitutions ofHis15, His36 and His43 did not reduce Lqh3 sensitiv-ity to pH, substitutions of His66 had a clear impact with the utmost decrease obtained with H66R(Table 3). Unexpectedly, ... onto the oocyte, suggesting that Lqh3sensitivity to pH is associated with some later stage inthe binding process to the channel. This is corrobor-ated by previous binding studies, which demonstratedthat ... 6B).DiscussionInsight into the molecular basis of preferential interac-tions of scorpion a-toxins with insect or mammalianNavs was thus far obtained mainly from mutagenesisand comparison...
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Báo cáo khoa học: A distinct sequence in the adenine nucleotide translocase from Artemia franciscana embryos is associated with insensitivity to bongkrekate and atypical effects of adenine nucleotides on Ca2+ uptake and sequestration pdf
... untreated with ADPthan in those treated with the nucleotide. This is in line with the experimental findings on Ca2+uptake capacityin the presence and absence of adenine nucleotides.Mitochondria isolated ... roteinsequence with that of other species (Xenopus, Drosophila,mouse isoforms 1, 2, and 4, rat isoforms 1 and 2,bovine isoforms 1, 2, 3, and 4, and human isoforms 1,2, 3, and 4) is shown in Fig. ... failed to inhibitANT operation as compared with the control (5 mmNH4OH, which is the vehicle of BKA, trace c). With the same BKA stocks, this poison fully inhibited ANToperation in rat liver...
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Báo cáo khoa học: Homologous desensitization of guanylyl cyclase A, the receptor for atrial natriuretic peptide, is associated with a complex phosphorylation pattern pot
... top). This suggests that thisphosphorylation site, in contrast with the others, is phosphorylated during homologous desensitization.Hence, homologous desensitization of GC-A is associ-ated with ... alsoincluded in all subsequent purifications. After incubation with lysis buffer for 30 min on ice with vigorous vortexing,the cell debris and nuclei were pelleted by centrifugation at2000 g for ... by incubation with anti-FLAG IgG coupledto agarose beads (M2 agarose, Sigma-Aldrich) for 2 h at4 °C, followed by extensive washing with Tris buffer. Theprotein was eluted in Tris buffer containing...
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Báo cáo khoa học: Mutation of epidermal growth factor receptor is associated with MIG6 expression docx
... hormone administration. For the tran-scriptional analysis, cells were incubated with 10 nm EGFfor 0.5, 1, 2, 4, 6 or 10 h and then washed twice with NaCl ⁄ Pi. Cells not treated with growth ... non-small-cell lung cancer (NSCLC) cell line H1299 with EGFR overexpression (wild-type: EGFR-WT) and with or without the mutation in which Leu858 is substituted with Arg (mutant: L858R), in addition tothe ... RALT is known to be a transcriptional feed-back regulator of the ErbB-MAPK signaling pathway[14,15] and its loss is associated with ErbB2 ⁄ HER-2oncogenic potency leading to Herceptin resistance[16]....
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báo cáo hóa học:" Higher percentage of CD133+ cells is associated with poor prognosis in colon carcinoma patients with stage IIIB" pptx
... functionof CD133 is unknown, preliminary evidence proposedthat expression of CD133 is associated with the activationof stemness-related signal pathway, resistance to apopto-sis and bioenergetic ... cells is associated with the prognosis of cancer patients, the over-population hypothesis would be substantially supported.By now, the relationship between the percentage ofCD133 and prognosis ... tumor cells andthe prognosis of colorectal cancer patients. This studyshowed that the percentage of CD133+ tumor cells was associated with the prognosis among patients with locallyadvanced colon...
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báo cáo hóa học:" A MIF haplotype is associated with the outcome of patients with severe sepsis: a case control study" pdf
... Kaczmar-ski EB, Borrow R, Wilson AG: The tumor necrosis factor poly-morphism TNF (-308) is associated with susceptibility tomeningococcal sepsis, but not with lethality. Crit Care Med2009, 37:1237-1243. ... characteristics of patients with severe sepsis and patients with abdominal surgery without signs of infection or inflammation (* unpaired t test, ** Fisher's exact test).Severe Sepsis(n ... pol-ymorphism with inflammatory bowel disease in Chinese Hanpopulation. Cytokine 2008, 41:44-47.28. Hizawa N, Yamaguchi E, Takahashi D, Nishihira J, Nishimura M:Functional polymorphisms in the...
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Báo cáo hóa học: " Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer" ppt
... assisted with the data collection and helped draft the manuscript. IBJ assisted with thestatistical analysis. JM assisted with data collection and helped to draft themanuscript. JB assisted with ... expressionwas associated with a significantly improved OS in uni-variate and multivariate analysis. This is in line with previous findings from two independent breast cancercohorts where RBM3 was associated ... found to be associated with agood prognosis in both cohorts. RBM3 expression wasalso examined in vitro using the cisplatin sensitiveovarian cancer cell line A2780 and its cisplatin resistantderivative...
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Báo cáo hóa học: " MMP-1 is a (pre-)invasive factor in Barrettassociated esophageal adenocarcinomas and is associated with positive lymph node status" doc
... wassignificantly (p = 0.01) lower in comparison to EAC without BE. Normal tissue is considered as one-fold (b). Statistically significant value is indicated with an asterisk.Grimm et al. Journal of Translational ... survivaleffect [46] but may be associated with neoplastic pro-gression in BE [47]. Therefore, our results may indicatethat MMP-1 expression is associated with multistep car-cinogenesis according to clonal ... same as described for immunohistochemistryTable 1 Clinicopathological characteristics of the EAC studypopulation (with and without histological proven BE)Characteristics Patients(n = 60)MMP-1...
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