tms hd eeg detects changes in the brain s capacity for integrated information during sleep
CHOLESTEROL INDUCED GENE EXPRESSION CHANGES IN THE BRAIN AND CEREBRAL VESSELS
... chronically induced massive gene expression changes in the brain and cerebral vessels, possibly through the mediation of SREBP signaling, and it might affect similar pathways in both of these tissues Therefore, ... novo synthesis (Farooqui, 2011) The highest rate of cholesterol biosynthesis in the brain is found in the first postnatal weeks in humans and this may be associated with the development of CNS (Farooqui, ... maintain cholesterol homeostasis One of the regulatory mechanisms involves insulin-induce genes (INSIGs) and sterol regulatory element binding proteins (SREBPs) (DeBose-Boyd, 2008) This mechanism...
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Báo cáo khoa học: "Changes in the incidence and outcome for early acute kidney injury in a cohort of Australian intensive care units" docx
... created [25] Sepsis/septic shock encompassed admissions for primarily sepsis-related diagnoses, and included sepsis associated with pneumonia, gastrointestinal disease, urinary tract infections, central ... hours of ICU admission was assessed using the APACHE II, APACHE III and Simplified Acute Physiology Score II scoring systems [26,27] Pre-existing comorbid illnesses were defined using the chronic ... nervous system infections, soft tissue infections, and the ANZICS APD-specific diagnostic code additions for sepsis with shock of undetermined source A primary cardiac diagnosis encompassed nonsurgical...
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Poultry of the Middle in the U.S.: ‘Implications for Sustainable Producers & Scaling Up’ pdf
... law in Europe and used in slaughterhouses for other livestock in the U .S stunning is not a requirement in poultry processing in the U .S Stunning renders the birds insensible to pain It is also ... companies in 38 states in the U .S take their animals to state-inspected facilities for processing A major disadvantage is that meat processed in state-inspected facilities cannot cross state lines for ... this study This study examines the characteristics that distinguish this group of poultry producers and processors It seeks to better understand their business structures, the infrastructure they...
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Báo cáo y học: " Evolution of changes in the computed tomography scans of the brain of a patient with left middle cerebral artery infarction: a case report" pps
... Radiologists guidelines now suggest that such scans should be performed within the initial 24 hours of presentation The CT scanning of such patients is performed without the use of intravenous contrast ... millimetres above this area, but is seen in Figure 2) This is not in keeping with the patient 's clinical signs (right-sided weakness) and is too dense to represent blood and shows no surrounding oedema ... vessel supplying that area There is an even greater time lag before definite CT scan changes of an infarcted area of brain tissue may be seen However, changes such as loss of insular ribbon, obscuration...
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Characteristics of Leachate from Citrus Groves and their Changes in the Collecting Reservoirs in Matsuyama, Japan
... respectively Stream water samples were collected at the middle parts of the grove from points Sampling points St.1 and St.2 are in the same stream, and sampling point St.3 is in the other stream ... The two streams flow together to be one stream and the sampling point St.4 is situated in the joined stream, which is the only stream that flows into the reservoir The reservoir water was also ... Hiroshima, and others Therefore, it is considered that a large amount of pollutants runs into the sea from the urban as well as industrial areas As the area around the Seto Inland Sea has a small amount...
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Tài liệu Báo cáo khoa học: Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia pptx
... The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents Role for Nrf1 in gamma-gcs (1) and gss expression in mouse fibroblasts ... tested the level of mRNA for subunit VIIa, which is expressed as isolog H and L The L isolog is ubiquitously expressed in all the tissues whereas the H isolog is detected in the heart and skeletal ... ATP synthesis in control PC12 cells was nearly twice that of macrophages suggesting vastly different energy needs of these cell types The mitochondrial respiration-coupled ATP synthesis was inhibited...
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Báo cáo khoa học: Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability docx
... storage in LDs The PI3K ⁄ Akt signaling pathway stimulates lipogenesis via SREBP-1 FAS is the enzyme responsible for the synthesis of palmitate, the precursor of FFAs The inhibition of signaling ... resulted in the disappearance of LDs (Fig 2), suggesting that these cells carried out lipogenesis (de novo synthesis of lipids) in control cultures Interestingly, cerulenin also inhibited LD formation ... as they accumulated lipids mainly in the presence of serum Thus, our results suggest that the fatty acids necessary for LD formation during exposure to NPs are synthesized de novo by the cells,...
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Changes in the Economic Value of Variable Generation at High Penetration Levels: A Pilot Case Study of California pot
... decreases The decrease indicates that incumbent PHS is used less frequently in the high CSP6 cases than it is used in cases without VG This is presumably because the system has access to considerable ... price spikes stays relatively constant with increasing VG, suggests that just as sufficient generation capacity is being added in the case without VG as is being added in the cases with increasing ... welfare for missing AS targets and eventually for involuntary load shedding The scarcity price levels for missing AS targets are set following the scarcity prices used at the CAISO (CAISO, 2009) The...
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Báo cáo khoa học: Local changes in the catalytic site of mammalian histidine decarboxylase can affect its global conformation and stability pptx
... hypothesis proposed above To further address this hypothesis, we have characterized the protein conformational changes during catalysis, by using a strategy similar to that used previously for the ... hypothesis by Koshland, it is well established that the interactions between an enzyme and its substrate induce conformational changes at the active site In most cases, these conformational changes ... could induce global conformational changes in the intact holoenzyme, reinforcing our starting hypothesis Evidence has also been obtained suggesting differences between these conformations before...
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Báo cáo khoa học: Large conformational changes in the Escherichia coli tryptophan synthase b2 subunit upon pyridoxal 5¢-phosphate binding pot
... within a dimer (c) PLP binding strengthens the b–b subunit association as a result of increases in the hydrophobic interactions, hydrogen bonds and salt bridges, resulting in stabilization of the ... results in Schiff-base formation involving Lys87 This interaction triggers a slow local conformational re-arrangement in other regions, including residues of the long loop of the C domain These changes ... asterisks in the sixth and seventh lines represent those residues binding PLP via hydrogen bonds (blue), hydrophobic interactions (black) or covalent bonds (red) in Ecb Changes in the intersubunit...
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the changes in the narratots view of sonny
... that the narrator found himself understanding Sonny 's manhood He was on the same levelas his brother, and he was finally seeing his brother as he truly was When the narrator felt these feelingshe ... single event brings the narrator out of the second phase and intohis third phase It is in this final pahse that the narrator obtains a true understanding of Sonny The deathof the narrator 's daughter ... interested in what Sonny interested in Finally, he was willing to sit and listen to Sonny instead oftelling him how to run his life All of these were drastic changes from when their mother had first...
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Báo cáo khoa học: Protective effects of endomorphins, endogenous opioid peptides in the brain, on human low density lipoprotein oxidation pdf
... endomorphins and GSH The reaction conditions and the initial concentration of the substrates are the same as described in the legends of Fig for reactions conducted in LDL Data are the means of three ... free amino acids such as Trp and Phe cannot react with galvinoxyl radicals (data not shown) Therefore, it is suggested that both the indole ring on the Trp as well as the side chain on the indole ... prevents the formation of any nonspecific TBARS, as well as preventing decomposition of AAPH during the subsequent boiling The solution was heated in a boiling water bath for 15 After cooling, the...
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Báo cáo khoa học: Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site potx
... affinity for indinavir The changes in protease structure and interactions with indinavir must be considered during the design of new inhibitors for resistant HIV Ó FEBS 2004 HIV protease crystal structures ... Asp25¢ also showed a small shift relative to their positions in the other complexes, and less symmetrical interactions with the hydroxyl of indinavir (Table 5), as well as the close contacts ... the effect of the mutation The lower stability of PRL90M is consistent with the observed small structural changes in Asp25 and Asp25¢ at the dimer interface The DDG values for binding of indinavir...
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Biomechanical Walking Pattern Changes in the Fitand and Healthy Elderly docx
... Hz The smoothed coordinates then became inputs to the standard link-segment model ing during walking These variables are presented in the Table Results and Discussion In addition to the joint ... those measures Several of these studies have related these gait changes to falls,l8 rnobility,l9 and postfall anxiety.20 All of these studies have made inferences about the reasons for the observed ... illustrated by the power curves shown in Figure and is described in the Table Figure shows the average power plots for the 11 repeat trials for the same subject discussed previously The time integral...
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Báo cáo khoa học: An enzymatic mechanism for generating the precursor of endogenous 13-cis retinoic acid in the brain docx
... analysis in the present study shows that zebrafish RPE65 is predominantly expressed in the eye and, to a lesser extent, in the brain Detection of RPE65 in the brain was not unexpected because a ... expressed in the brain, and is only weakly expressed in the eye The high level of 13cIMH expression in the brain supports the notion that it may function in the pathway of 13cRA synthesis, and ... and result in improper neural communication The results obtained in the present study also showed predominant expression of 13cIMH in the brain, further supporting its proposed role in the modulation...
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Báo cáo khoa học: Biochemical evidence for conformational changes in the cross-talk between adenylation and peptidyl-carrier protein domains of nonribosomal peptide synthetases ppt
... to observe a reasonable degree of degradation in the former case These findings indicated, within the resolution of this assay, that induced the same conformational changes as the substrates ATP ... proteolysis by decreasing the rate of cleavage, indicating that the complex with the amino acyl adenylate shows less accessibility for the proteaserecognition sites at the solvent-exposed linkers (see ... means to monitor these changes with intact proteins in solution Furthermore, a close inspection of the results showed differences between the apo-protein and the holo-protein Interestingly, the...
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Báo cáo khoa học: Inactive forms of the catalytic subunit of protein kinase A are expressed in the brain of higher primates potx
... acids encoded by exon The fact that the CbD4 variants were expressed in NT2-N cells prompted us to investigate whether these variants are found in other human Cb-expressing tissues, such as brain ... Next, we searched for these splice variants in the brain of other species Rhesus monkey brain and mouse brain cDNAs were PCR amplified using the human and mouse Cb common primers (Table 1), respectively ... variants in Rhesus monkey but not in mouse brain cDNA In the latter species, several studies demonstrate at least three Cb splice variants exist [20,25,26] Based on these results, it may be hypothesized...
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Báo cáo khoa học: acids in the brain: D-serine in neurotransmission and neurodegeneration ppt
... whereas in adult rats, d-serine is exclusively present in neurons in these regions [38] Neuronal D-serine in NMDAR regulation Is there a role for neurons in synthesizing and releasing d-serine? ... suggesting that d-serine, rather than glycine, is the dominant NMDAR co-agonist in the supra-optic nucleus [11] The role of endogenous d-serine as the foremost co-agonist of NMDARs, as suggested ... Many questions remain to be solved regarding the relative roles of glia versus neurons in the synthesis and release of d-serine In the original model of d-serine signaling, d-serine was thought...
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