ms with and without interferon beta 1a treatment to define the dynamic changes of metabolites in the brain and to monitor disease progression
Báo cáo sinh học: " Neopterin production and tryptophan degradation during 24-months therapy with interferon beta-1a in multiple sclerosis patients" docx
... we investigated the dynamic profile of neopterin and kyn/ trp ratio and its correlation with the clinical features in patients with RRMS treated with two different doses of IFNb -1a Treatment with ... group, thus exposing patients treated with the LD to the risk of early relapses in the first months of treatment The observed patterns of neopterin production over the years of IFNb -1a treatment probably ... effects) aspect of IFNb -1a biological activity Initially, IFNb -1a administration may result in a sharp increase in the neopterin levels owing to the acute, proinflammatory actions of IFNb -1a [35,36]...
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báo cáo hóa học:" Neopterin production and tryptophan degradation during 24-months therapy with interferon beta-1a in multiple sclerosis patients" pot
... we investigated the dynamic profile of neopterin and kyn/ trp ratio and its correlation with the clinical features in patients with RRMS treated with two different doses of IFNb -1a Treatment with ... group, thus exposing patients treated with the LD to the risk of early relapses in the first months of treatment The observed patterns of neopterin production over the years of IFNb -1a treatment probably ... effects) aspect of IFNb -1a biological activity Initially, IFNb -1a administration may result in a sharp increase in the neopterin levels owing to the acute, proinflammatory actions of IFNb -1a [35,36]...
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Báo cáo khoa hoc:" Serum S100B in primary progressive multiple sclerosis patients treated with interferon-beta-1a" pps
... sensitive to disease progression in PPMS This supports the view that PPMS is less inflammatory than other forms of MS and that serum S100B would be ineffective as a surrogate marker of disease progression ... progression in this subgroup It would be valuable to identify surrogate markers of clinical progression in PPMS to aid the development of effective therapeutic intervention, since clinical trials with ... levels of S100B at 3-month intervals in subjects with primary progressive MS (PPMS) The key questions were whether serum S100B levels correlated with disability or MRI findings in patients with PPMS,...
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Báo cáo y học: "Dynamic changes of serum SARS-Coronavirus IgG, pulmonary function and radiography in patients recovering from SARS after hospital discharge" ppt
... contact with SARS patients or is part of a cluster of cases of SARS or there is clinical evidence of having infected other patients (1.2) The individual has a history of recent travel to an area ... from January to June in 2004 Tables and show the dynamic changes of SARSCoV IgG in patients with positive tests for SARS-CoV IgG within the year after discharge, indicating that the serum SARS-CoV ... MRI examinations 3–6 months later Clinical Diagnostic Criteria for the Patients with SARS Disease in Mainland China [3] (1) Epidemiological history (1.1) The individual has a history of close...
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Báo cáo khoa học: "Use of dynamic microsimulation to predict disease progression in patients with pneumonia-related sepsis" docx
... changes in both the total and component SOFA scores) and allows the progression of disease to depend upon the duration of illness and the recent history, namely whether the patient is improving, ... whether the patient's health is improving, worsening, or staying the same by comparing whether the SOFA scores are declining, rising, or remaining stable compared with the prior day's score Finally, ... movement to or from an ICU, discharge, or death) The clinical detail contained in the GenIMS data also allowed us to estimate the progression of disease over time in terms of both the level of illness...
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Báo cáo hóa học: "Regulatory T cell frequency in patients with melanoma with different disease stage and course, and modulating effects of high-dose interferon-a 2b treatment" pptx
... Page of 13 Figure Determination of transforming growth factor-b, interleukin-10 and autoantibody in interferon- a 2b-treated patients with melanoma (A) Transforming growth factor-b (TGF-b), (B) interleukin ... again perhaps because of the small size of the sample These preliminary data have suggested that the evaluated immunoregulatory proteins and autoantibodies are not modulated by IFN-a 2b within the ... understanding of the mechanism of action of IFN-a 2b may facilitate the development of treatment strategies to increase efficacy and reduce toxicity, ultimately leading to a better standard of care...
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báo cáo hóa học: " Comparison of the discriminative ability of a generic and a condition-specific OHRQoL measure in adolescents with and without normative need for orthodontic treatment" potx
... de Oliveira CM: The planning, contracting and monitoring of orthodontic services, and the use of the IOTN index: a survey of consultants in dental public health in the United Kingdom Br Dent J ... discriminative ability of OHIP-14 and CS-OIDP attributed to malocclusion between groups with and without normative need for orthodontic treatment These findings differed according to the indicator ... Comparing and contrasting two orthodontic indices, the Index of Orthodontic Treatment need and the Dental Aesthetic Index Am J Orthod Dentofacial Orthop 1996, 110(4):410-416 Beglin FM, Firestone...
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Báo cáo y học: "Serum levels of biomarkers of bone and cartilage destruction and new bone formation in different cohorts of patients with axial spondyloarthritis with and without tumor necrosis factor-alpha blocker treatment" ppt
... the data analysis, and helped in the drafting of the manuscript JL performed the statistical analysis and helped in the drafting of the manuscript RH participated in the data collection and the ... understanding of the sequence of events in the spine Therefore, we analysed vasoendothelial growth factor (VEGF), metalloproteinase-3 (MMP-3), and bone-specific alkaline phosphatase (BALP) in the ... levels at baseline and after 36 to 52 weeks of treatment with adalimumab (Figure 3) Interestingly, the difference of serum levels of VEGF between weeks 36 to 52 and baseline (d_VEGF) and d_MMP-3...
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Báo cáo y học: "Cost estimates of HIV care and treatment with and without anti-retroviral therapy at Arba Minch Hospital in southern Ethiopia" docx
... the cost-effectiveness and sustainability of the intervention A costing study of ART provision in Ethiopia may offer useful insights into the functioning of such treatment, and provide a premise ... dividing the total laboratory overhead cost by the total number of laboratory tests during the base year The recurrent and capital unit overhead costs therefore remained constant for all types of ... haematology test, and imaging examination with 85%, 61% and 56% of the totals, respectively Recurrent costs were the major components of the outpatient consultation, clinical chemistry and other...
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Báo cáo y học: "Different effect of exercise on left ventricular diastolic time and interventricular dyssynchrony in heart failure patients with and without left bundle branch block"
... product of absolute systolic time and heart rate and expressed in seconds per minute Diastolic time was calculated as the cardiac length (RR interval) minus the duration of systole To define diastolic ... evaluated the effect of exercise on heart rate corrected diastolic time in IDCM patients yielded the following findings: LBBB was a major determinant of the duration of LV systole, irrespective of the ... found in both IDCM subgroups Results Systolic and diastolic time intervals The clinical characteristics and time interval details of the patient groups and the control group are presented in Table...
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CD4 lymphocyte dynamics in Tanzanian pulmonary tuberculosis patients with and without HIV co-infection ppt
... HIV uninfected and 154 HIV infected hospitalized TB patients during the initial months of TB treatment [19] In that study the CD4 count increased in both the HIV infected and the HIV uninfected ... weakness of our study is the lack of data regarding symptoms of Immune Reconstitution Inflammatory Syndrome (IRIS), which might have explained some of the CD4 fluctuations The incidences of IRIS ... slightly increasing tendency during the observation period, which was interpreted as a positive effect of the TB treatment This finding is in line with results obtained from patients from Uganda...
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Network-Centric Operations Case Study - Air-to-Air Combat With and Without Link 16 pdf
... With and Without Link 16 findings of this report with four other pilots who have had experience with Link 16–equipped aircraft and with the new tactics Link 16 enables This process of gaining ... However, there was only limited understanding of how and why these improvements arose The Office of Force Transformation (OFT) and the Office of the Assistant Secretary of Defense for Networks and Information ... quality and distribution of information to the pilots in the example mission, resulting in an increase to both individual and shared information This is believed to be associated with an increase in...
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báo cáo hóa học:" Stem cells from umbilical cord blood do have myogenic potential, with and without differentiation induction in vitro" pdf
... complex of proteins (dystrophin-glycoprotein complex) responsible for the membrane maintenance of muscle cells A primary deficiency in any of these proteins induces to a secondary deficient of the ... myotube formation, resulting in the restoration of dystrophin expression These findings represent a possible tool for future cell therapy applications in DMD disease and for other muscular dystrophies ... cultured with differentiating human DMD myoblasts and myotubes even when the co-culture was maintained in growth media [36] The present results of co-culture of CD34+ and DMD myoblasts without the inductive...
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báo cáo hóa học: " Utility values for symptomatic non-severe hypoglycaemia elicited from persons with and without diabetes in Canada and the United Kingdom" potx
... prone to anxiety and panic attacks and these sequelae increase with the number of episodes [10,11] In order to avoid hypoglycaemic events, some patients alter insulin treatment intensity and others ... remunerated The study received ethical approval in the UK and in Canada and complied with the tenets of the Declaration of Helsinki Standardised Descriptions of Health States The derivation of health ... trading a number of remaining years of life in full health for receipt of a hypothetical treatment that would restore the person to full health The process incorporated a "ping-pong" approach with...
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báo cáo hóa học: " Health predicting factors in a general population over an eight-year period in subjects with and without chronic musculoskeletal pain" potx
... decided to study two cohorts based on the baseline pain report and not to include the change in pain status in the forming of the groups The forming of multiple groups, based on pain progression, ... factor highlight that this has to be taken into account both in care of patients and in all health promoting work at too complex picture Changes in pain status could though, together with other ... This is interesting with regard to the findings in this study with interaction analyses on sex, where former smoking was associated to better score in baseline SF-36 domains RP and RE in females,...
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báo cáo hóa học: " Comparing the SF-12 and SF-36 health status questionnaires in patients with and without obesity" pot
... than the SF-36 in explaining variations in QOL across BMI Since the MCS36 has been shown in this and other studies to be relatively insensitive to differences in BMI, using the MCS-12 instead of ... cannot be used to compare the QOL impact of obesity and changes in weight with the QOL impact of other diseases Thus, studies of obesity may need to include a combination of different instruments ... unclear In this context, we compared the SF-12 and the SF-36 in a cross-sectional sample of primary care patients of varying body weights to examine the correlation between the two instruments and their...
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báo cáo hóa học: " Kinematics and muscle activity of individuals with incomplete spinal cord injury during treadmill stepping with and without manual assistance" docx
... subjects with spinal cord injury walking with (MA) and without (WO) manual assistance and control (C) subEMG profiles for EMG profiles for subjects with spinal cord injury walking with (MA) and without ... subjects with spinal cord injury walking with (MA) and without (WO) manual assistance and control (C) subEMG profiles for EMG profiles for subjects with spinal cord injury walking with (MA) and without ... subjects with spinal cord injury walking with (MA) and without (WO) manual assistance and control (C) subEMG profiles for EMG profiles for subjects with spinal cord injury walking with (MA) and without...
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báo cáo hóa học:" Effects of low intensity pulsed ultrasound with and without increased cortical porosity on structural bone allograft incorporation" doc
... findings have prompted recent efforts using LIPUS to mitigate the onset of osteoporosis in patients with spinal cord injuries and for the treatment of osteoporosis in elderly women[16,17] Combining ... cephazolin antibiotic (1 g IV) was given at induction and at the end of surgery With the sheep in dorsal recumbancy, a 12-cm skin incision was created from the left knee joint to the tarsocrural joint ... from plots of torque and angular displacement data and normalized to the value of the iCTL to minimize the inherent variability in torsional properties between animals http://www.josr-online.com/content/3/1/20...
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Báo cáo hóa học: " Differential inhibition of human cytomegalovirus (HCMV) by toll-like receptor ligands mediated by interferon-beta in human foreskin fibroblasts and cervical tissue" pdf
... TLR4 and TLR2 respectively) associated with their infections [8-10] The clinical studies contrast with the findings of our in vitro and ex vivo studies where inhibition by defined TLR ligands ... experiments to determine if exposure to defined TLR ligands affects HCMV infection and found that TLR ligands inhibit HCMV infection of both HFF and ectocervical explant tissue through induction of IFNβ ... measured to determine the responsiveness of HFF and explants to the TLR ligands The IL-8 response pattern to the TLR ligands was also different between HFF and ectocervical explants with only TLR3 and...
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báo cáo hóa học:" Correlation and comparison of Risser sign versus bone age determination (TW3) between children with and without scoliosis in Korean population" doc
... anteroposterior standing radiogram of spine while evaluating the patients with scoliosis Therefore it is better to correlate the reliability of Risser sign with skeletal age to find out the average ... conception and design of data, analysis and interpretation of data, drafting the manuscript and revising it critically, SWS has contributed in conception and design of data, drafting the manuscript and ... and also to compare the reliability of skeletal age with that of chronological age in Korean population Using the control group in our study we also aimed at to find out the Table 1: Values of...
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