the distrubances in the monetary financial mechanism of world economy
Báo cáo Y học: Role of conserved residues within helices IV and VIII of the oxaloacetate decarboxylase b subunit in the energy coupling mechanism of the Na+ pump ppt
... binding ligand Sodium ions may still bind to the N373L mutant through coordination to the other ligands of the binding site (center I), but the binding becomes much weaker as emphasized by the ... is the shift of the pH optimum from near neutral in the wild-type to pH 9.2 in the R389A mutant, which is in accord with an increase in the pK of Y229 if the stabilizing R389 residue is lacking ... option As the next step, we envisage binding of the second Na+ ion to the Y229 and S382 including site (center II) As these residues are within the hydrophobic core of the membrane the electroneutrality...
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báo cáo khoa học: " The function and mechanism of COX-2 in angiogenesis of gastric cancer cells" pdf
... Up-regulation of cox-2 expression and activity in the ulcer base not only during the acute phase of inflammation but also in the ulcer healing stage and especially in areas of intense tissue ... of gastric cancer cells in vitro and in vivo A, The growth rate of the cells was detected using MTT assay as described in “Materials and Methods” The value shown was the mean of three determinations ... control cells In order to investigate the angiogenic property of COX-2 in endothelial cells, the in vitro tube formation of HUVEC was assessed As shown in Figure 4, 5, Figure Down-regulation of COX-2...
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CITIZEN’S GUIDE TO THE 2011 FINANCIAL REPORT OF THE UNITED STATES GOVERNMENT pdf
... achieving an audit opinion The cost of maintaining effective financial operations is increasing, driven largely by the growing and high costs agencies are incurring to modernize agency financial ... position at the end of the fiscal year, explains how and why the financial position changed during the year, and provides insight into how the Government’s financial condition may change in the future ... contains the names and websites of the significant Government entities included in the Report’s financial statements Details about the information in this Financial Report can be found in these...
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Báo cáo khoa học: The crystal structure of pyruvate decarboxylase from Kluyveromyces lactis Implications for the substrate activation mechanism of this enzyme ppt
... [16], these domains are termed the PYR domain (binding the aminopyrimidine ring of ThDP), the R domain (binding regulatory effectors), and the PP domain (binding the diphosphate residue of ThDP) ... domain, green; C-terminal PP domain, blue; domain-connecting loops, yellow) The cofactors are depicted in space-filling mode The positions of the N-terminal and C-terminal amino acid residues of the ... binding of the cofactors ThDP and Mg2+ at the interface between two subunits The aminopyrimidine ring of ThDP is bound at the PYR domain of one subunit The diphosphate residue is bound to the PP...
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Báo cáo vật lý: "The Kinetics and Mechanism of the Core-shell Styrene-butyl Acrylate Polymerisation" pdf
... initiation step As in the case of the SLS surfactant, the dominant function of the surfactant is in establishing the initial charge, which will influence the formation of micelles, and thereby micellar ... Rp is the polymerisation rate of the styrene core, and k is the rate reaction constant in the formation of the styrene core 3.4 Mechanism of Reaction in the Formation of the Styrene Core The order ... are in the initiation step, in which the chain initiation is directly formed, and the radicals of the styrene core directly collide with the BAs CONCLUSION The reaction kinetics for the synthesis...
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Báo cáo y học: "Understanding the nature and mechanism of foot pain" ppt
... http://www.jfootankleres.com/content/2/1/1 Classification of foot pain The difficulties in clearly defining pain have impeded the development of clinically relevant pain models capable of guiding foot pain classification and communication ... placebo The 'placebo effect' is the change in outcomes observed following administration of the placebo intervention Due to the biologically inert nature of the placebo intervention, the changes ... confusingly used as a descriptor of pain history and as a prognostic statement for pain [34] The International Association for the Study of Pain (IASP) defines chronic pain as any pain persisting...
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Organizing marketing activities for Vietnamese-Owned automobile assemblers in the present development process of Vietnamese economy
... exceeds the cost of the activities, thereby resulting in a profit margin The primary value chain activities are: Inbound Logistics: the receiving and warehousing of raw materials and their distribution ... create the scientific basis for establishing the contents of implementing marketing plan in after, the thesis focus on analyze the main factors in the marketing program through distinguish the marketing ... both in structure and contents so they did not gained the high attention of customer even in awareness They will face the pressure from the integrated of economy, especially in given the deadline...
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Characterisation of the effects and mechanism of action of rapamycin and genistein on acute myeloid leukemia using high throughput techniques
... on their binding to specific cytosolic binding proteins called immunophilins Rapa specifically binds to the immunophilin FKBP12 (FK506 binding protein of 12 KDa) Other members of this class include ... domain The ternary complex formation is due to the presence of the FRB (FKBP12/rapamycin binding) domain The kinase domain lies sandwiched between the FRB and the FATC domains, at the C-terminus ... constituent of the protein ubiquitination pathway Working on this clue, we identified that the time dependent G1 arrest is in fact the result of the inhibition of Skp2, leading to the accumulation of...
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Structural study revealing the unique enzymatic mechanism of the severe acute respiratory syndrome (SARS) coronavirus main protease highly mediated by the extra domain
... the N-finger, are inserted into the cleft between domain II and domain III of the parent protomer, and interact with domain III of the opposite protomer In this thesis, the two β-barrel domains ... protomer In the absence of these two interactions, the active site and the S1 substrate binding region will lose their competent conformations (Lee et al 2005) Interestingly, the binding of a native ... determined by the interactions between Ser1 from the opposite protomer, and Phe140 from the parent protomer These interactions are certainly important in maintaining the catalytic loop in the catalytically...
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The International Financial Integration of China and India
... The International Financial Integration of China and India Paper Outline I Introduction II The International Financial Integration of China and India: Basic Stylized Facts III The Domestic Financial ... reduction in the absolute level of investment in tandem with a decline in the level of enterprise savings With an increase in market-driven investment and a decline in savings, the prediction of an increased ... changes in their domestic financial sectors, this analysis is relevant in projecting the future evolution of the international financial system The main current international financial impact of India...
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Báo cáo y học: "Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action"
... in the development of the oxidative stress (68) If our findings are proven by further studies involving a larger number of patients, ultra-low microcurrent therapy might change the concept of ... pathogenesis of insulin resistance in humans using magnetic resonance spectroscopy Obesity (Silver Spring) 2006;14 (Suppl 1): 34S–40S 31 Boden G Role of fatty acids in the pathogenesis of insulin resistance ... and the metabolic syndrome (30) In these conditions there is an elevation of both glucose and free fatty acid levels in the blood and an increase in oxidative stress (30,31) The high degree of...
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The Political Economy of Distress in East Asian Financial Institutions
... Asia financial crisis a good event to investigate the role of these connections in causing and resolving financial institutions’ distress Furthermore, the general causes of the East Asian financial ... following: i) the financial institution was closed; ii) the financial institution was merged with another financial institution; 10 iii) the financial institution was recapitalized by either the Central ... terms of number of nonbank financial institutions, our coverage is 4.0% in Indonesia, 81% in Korea, 54.9% in Malaysia, 27.5% in Thailand and 5.3% in the Philippines In terms of total assets, the...
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Tài liệu Global Retail Lending in the Aftermath of the US Financial Crisis: Distinguishing between Supply and Demand Effects ppt
... is whether the growing trend in globalization in banking results in events such as the U.S financial crisis affecting the real economy in other countries through the bank lending channel In particular, ... provide financial access to the community in which they operate and in particular to customers without access to financial services with other financial institutions The business model of savings ... after the Beginning of the Financial Crisis The main objective in this paper is to separate supply and demand effects of the financial crisis on consumer lending So far we have analyzed the supply...
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Tài liệu Báo cáo khoa học: On the mechanism of action of the antifungal agent propionate Propionyl-CoA inhibits glucose metabolism in Aspergillus nidulans doc
... compensates for the initial decrease of the oxaloacetate concentration in the equilibrium due to the accumulation of NADH [25] Lineweaver–Burk diagrams were obtained by use of the worksheet of the program ... cells), even in the mutant strain Determination of the intracellular volume In order to obtain the intracellular concentration of accumulated acyl-CoA esters, it was necessary to know the internal ... NADPÆmin)1Æmg protein)1 Determination of maintenance In order to calculate the amount of glucose used for maintenance, the wild-type strain A26 was used Four 100-mL aliquots of glucose minimal...
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Tài liệu Báo cáo khoa học: The mechanism of a-proton isotope exchange in amino acids catalysed by tyrosine phenol-lyase doc
... from the amino group to the a-carbon atom of the quinonoid intermediate should go faster than the isotopic exchange of the proton in the active site For the reaction of L-methionine, where no internal ... a-amino group in the external aldimine defines automatically the positions of the a-proton and the side chain of any bound amino acid The lability of the a-proton observed for a large number of ... the interaction of the side group of L-methionine with Arg100 in the considered reactions For L-aspartic acid the interaction of the distal carboxylic group with Arg100 takes place in the quinonoid...
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Tài liệu Báo cáo khoa học: A role for the intersubunit disulfides of seminal RNase in the mechanism of its antitumor action docx
... reconstituted in the presence of growing broblasts into the parent dimeric protein, which is internalized as a native-like dimeric RNase They also indicate for the rst time that when BS-RNase is internalized ... cysteine residues originally involved in the intersubunit disulde bonding of BS-RNase, are irreversibly blocked through S-alkylation In the active MSSAE and MSSG monomers, instead, the two Cys residues ... To verify the hypothesis described above, SVT2 broblasts were grown at 37 C in the presence of 20 lgặmL)1 of radioactively labelled 125I-labelled MSSAE in binding buffer (DMEM containing mgặmL)1...
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Tài liệu Báo cáo khoa học: A single amino acid substitution of Leu130Ile in snake DNases I contributes to the acquisition of thermal stability A clue to the molecular evolutionary mechanism from cold-blooded to warm-blooded vertebrates docx
... were obtained Phylogenetic trees with the nt sequence of the open reading frame (ORF) of their cDNAs and the corresponding aa sequences, in Table Summary of the purification of DNases I from the pancreases ... relative to the enzyme [38], were also found in all the snake enzymes The unique cysteine-rich-terminus and inserted Ser in the Ca2+-binding site of amphibian DNases I [14], were not observed in the ... be involved in changing the thermally stable characteristics of vertebrate DNases I, substitution of Ile130Leu in snakes and insertion of Ser205 in amphibia It is interesting that DNases I of...
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Báo cáo khoa học: Conservation of the egg envelope digestion mechanism of hatching enzyme in euteleostean fishes pot
... result of the formation of e-(c-glutamyl) lysine cross-links between subunit proteins of the envelope, mainly between inner layer subunit proteins [10] At the time of hatching of the embryo, the inner ... result of the existence of e-(c-glutamyl)-lysine cross-links in FE (d) The 25 kDa band was observed in the hatching liquid but not in the FHCE ⁄ FLCEdigests of UFE The N-terminal sequence of the ... located inside of ZP-domain of FhChgL In natural hatching, a part of the 35 kDa digest was further digested and degraded into the 25 kDa digest The SDS ⁄ PAGE patterns of the digests of isolated...
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Báo cáo khoa học: Transthyretin and familial amyloidotic polyneuropathy Recent progress in understanding the molecular mechanism of neurodegeneration pdf
... resulting from the occupancy of the first binding site [68] TTR is also involved in the transportation of retinol by forming a complex with the smaller retinolbinding protein (RBP) [69,70] The TTR–RBP–retinol ... structure of a TTR dimer is shown in Fig Native TTR is a tetramer and contains two identical thyroxine-binding sites located in a channel at the center of the molecule [67] The two binding sites ... ˚ H strand of the opposite dimer, creating a 50 A central channel that contains the two binding sites for thyroxine [81] The four binding sites for RBP are located on the surface of a TTR molecule...
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