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Tài liệu Báo cáo khoa học: Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) scaffold multi-PDZ domain protein 1 pptx
... signal is impaired.We finally examined the effect of deletion of the components of the PDZ binding motif on the signal-ing properties of the receptor in Ca2+imagingexperiments. Truncation of the ... and have elucidated the moleculardetails of this interaction. The primary source of olfactory signaling and the sites of expression of ORs are the ciliary structures of the OSNs. Interestingly, ... ORs. The observed effects can therefore only be taken as proof of the functional significance of the observed interac-tion. Further studies are necessary to shed light on the function of this interaction...
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Tài liệu Báo cáo Y học: Thermostability of manganese- and iron-superoxide dismutases from Escherichia coli is determined by the characteristic position of a glutamine residue pdf
... SODs is not governed by one or even two residues, but is most likely accomplished by the concerted effects of a combination of key residues.Further analysis of these and other mutant SODs is currently ... with the iron metal at the active site. The presence of iron is therefore a prerequisite for its effect and suggeststhat the absence of reactivity with the MnSOD mutants is due to the lack of ... which is structurally equivalent in the enzymes, is contributed by the N domain of FeSODs (Q69) and the C domain of MnSODs(Q146). Exceptions to this scheme include the substitution of Gln by His...
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Báo cáo khoa học: Interaction analysis of the heterotrimer formed by the phosphatase 2A catalytic subunit, a4 and the mammalian ortholog of yeast Tip41 (TIPRL) ppt
... Subsequently, the GST–PP2Aca:His–TIPRL complex was incubated withHis–a4 and the GST–PP2Aca:His–a4 complex wasincubated with His–TIPRL. Binding of His–TIPRL to the previously formed GST–PP2Aca:His–a4 ... yeast two-hybrid screen using the TIPRL as bait. PP2Ac is represented by a black bar for comparison. Numbers on the left of the gray bars indicate the first amino acid in the respective activationdomain-phosphatase ... complex is shown in Fig. 4C. In the reciprocal experiment,binding of His-a4 to the previously formed GST–PP2Aca:His–TIPRL complex was also observed (datanot shown). Because of the lower levels of...
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Báo cáo khoa học: Androgen receptor function is modulated by the tissue-specific AR45 variant ppt
... recruitment, due to the absence of the NTD. This might be overcome by the overexpression of cofactors. To test this hypothesis, weanalyzed the effects of two AR cofactors known tointeract with the AR LBD. ... that the ratio of both forms is essential for proper development of the mammarygland [22]. Analysis of human endometrial tumoursindicates that loss of the B-form is linked to poor prog-nosis ... in other tis-sues, including testis (Fig. 2A). In comparison, verylow levels of the AR transcript were detected in heart,as compared to liver or testis (Fig. 2B). The transcriptlevels of the...
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Báo cáo khoa học: The bioactive dipeptide anserine is transported by human proton-coupled peptide transporters doc
... mm. The Kivalue of anserine for the inhibition of [14C]Gly-Sar uptake via PEPT2 into SKPTcells was 0.033 ± 0.001 mm (Table 1). The apparent affinity of anserine is thereby lowerthan that of ... at the intestinal epithelium. The purpose of this study was to investigate whether anserine is a substrate of the H+⁄ peptide cotransporters 1 and 2 (PEPT1 and PEPT2). We firstassessed the ... lm.Construction of pNKS-hPEPT1 and in vitro cRNAsynthesis The X. laevis oocyte expression vector pNKS was kindlyprovided by Professor G. Schmalzing (RWTH, Aachen,Germany). This vector contains the 5¢...
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Báo cáo khoa học: The expression of retinoblastoma and Sp1 is increased by low concentrations of cyclin-dependent kinase inhibitors ppt
... of chase time. A representativeexperiment of the five performed is shown. The remaining Rb proteinlevels are expressed as the percentage of the Rb protein present at 0 h of CHX, for either the ... doi:10.1046/j.1432-1033.2003.03874.xTherefore, the effect of UCN-01 on the levels of Rbprotein may be caused by an increase in the synthesis of Rband by a decrease in its degradation. However, the effect onSp1 ... a positive effect caused by accumulation of the hypophosphorylated form or by a combination of the two mechanisms, in keeping with the self-regulation of the Rb gene by its own gene product,...
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Báo cáo khoa học: Proteolytic degradation of nitric oxide synthase isoforms by calpain is modulated by the expression levels of HSP90 potx
... andobviously the isolated proteins are degraded by the protease. On the basis of these observations, we canexplain not only the protective effect exerted by HSP90 on the digestion of NOS isozymes, ... described in the Exper-imental procedures. The areas of the peaks were normalized on the basis of the amount of protein loaded on the column. The val-ues reported are the arithmetical mean ± SD of three ... canprevent the degradation by calpain of both NOS by protecting the cleavage of the peptide bond close to the CaM binding site. This explains why both NOSare inactivated by calpain in the absence of...
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Tài liệu The Role of BCG Vaccine in the Prevention and Control of Tuberculosis in the United States: A Joint Statement by the Advisory Council for the Elimination of Tuberculosis and the Advisory Committee on Immunization Practices docx
... statistics of pulmonary tuberculosis in Denmark, 1925–1934: a statisticalinvestigation on the occurrence of pulmonary tuberculosis in the period 1925–1934, workedout on the basis of the Danish National ... Disease Controland Prevention (CDC) The Role of BCG Vaccine in the Prevention and Control of Tuberculosisin the United StatesA Joint Statement by the Advisory Councilfor the Elimination of ... for Disease Control and Prevention. The role of BCG vaccine in the pre-vention and control of tuberculosis in the United States: a joint statement by the Advisory Council for the Elimination of...
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Board of Governors of the Federal Reserve System Federal Deposit Insurance Corporation Office of the Comptroller of the Currency potx
... regular basis to determine, among other things, the validity of the assumptions, the severity of tests, the robustness of the estimates, the performance of any underlying models, and the stability ... viability.2 The Federal Reserve, the Office of the Comptroller of the Currency, and the Federal Deposit Insurance Corporation (collectively, the “agencies”) are issuing this guidance to emphasize the ... reasonableness of the results. Stress test results should inform analysis and decision-making related to business strategies, limits, risk profile, and other aspects of risk management, consistent...
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Báo cáo khoa học: Investigation of the kinetics and order of tyrosine phosphorylation in the T-cell receptor f chain by the protein tyrosine kinase Lck potx
... tyrosine by assaying the transfer of 32P by recombinant Lck on to each of the peptides. The rates of phosphorylation were found todepend on the location of the tyrosine, leading to the pro-posal ... exhibit the same kinetics as those located on the intact protein. Therefore, determination of the kinetics of phosphorylation of these peptides allows the order of phosphorylation of the six ... differences in the amino-acid context of the six f chain ITAM tyrosines affect the efficiency of theirphosphorylation by the kinase Lck, which probably contri-butes to the distinct patterns of phosphorylation...
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Báo cáo Y học: Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku-80 subunit is necessary for basal transcription of the WD gene ppt
... addition, the concurrent decrease in the level of Ku-70 from 0.5 to 12 h after transfection of Ku-80 IR gene is consistent with previous report that the stability of Ku-70 is compromised by the absence ... function in the maintenance of metal homeostasis and detoxification by forming strongcomplexes with several types of metal ions [16,17]. Given the existence of MREs in the promoter of the WD gene, ... identical to the Ku proteins. The effects of RNAi of the Ku-80 subunit and the truncated Ku-80 mutant on WD gene expressionTo examine the effects of the Ku protein on the regulation of WD gene...
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how the use of the diary form narrative is beneficial to the
... writing and book. One of the greatest benefits of the diarynarrative is that the reader is allowed see, and feel the emotional heartsand souls of the emotional characters. This is great because ... narrative. This was agood choice of how to write the novel since it was very beneficial to the plot of Dracula. Examples of how the diary form is beneficial to Dracula is seen in his writing and ... is not feeling too great and is trying hide something, the readerknows this, and therefore the reader knows everything that is happening; nothing is being hidden from the reader. An example of...
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PLANNING THE PROJECT MANAGEMENT WAY: EFFICIENT PLANNING BY EFFECTIVE INTEGRATION OF CAUSAL AND RESOURCE REASONING IN REALPLAN pdf
... robots10.012.014.016.018.0Numerical ValueA Look into Plans by Graphplanin the Blocks World domainLength of plan Number of steps in planClasses of Resource Allocation SchedulingINH-UNSOLV[5 10] INFRES FINRESEASYHARD[3 ... secs)Performance of Graphplan and Blackbox (satz)in the 6-block Shuffle Problem in Blocks WorldGP-GGP-SGP-TOTBB-TOT1.0 3.0 5.0 7.0# robots10.012.014.016.018.0Numerical ValueA Look into Plans by ... A^2_6Viewing actions as tasks of unit time (3-4 robots)1231FREEUNFREEFREEUNFREEUNFREEFREE1223A^1_6 A_8 A_9 A_10A_7A^1_5A_4A_3A_2A_1A^2_5 A^2_6Viewing actions as tasks of unit time (2 robots)12FREEUNFREEFREEUNFREEUNFREEFREEA^2_8A^3_61212121
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ chỉ tiêu chất lượng 9 tr 25