... venVolume 11 / Number / May, 1 968 ture the opinion that the larger the project, the more essential the structuring! A hierarchy of five logical levels might then very well turn out to be of modest ... from the picture At level we find the "message interpreter" taking care ofthe allocation ofthe console keyboard via which conV o l u m e 11 / N u m b e r / May, 1 968 versations between the operator ... been introduced and inigiahzed begin semaphore mutex; mutex := 1; parbegin begin L1 : P (mutex) ; critical section 1; V (mutex) ; remainder of cycle 1; go to L1 end; begin L2: P mutex); critical...
... angles (°) P 212 12 a ¼ 47.9 b ¼ 70.2 c ¼ 80.2 a ¼ b ¼ c ¼ 90° 1. 54 20 1 .6 98 .1 (89.8) 0.079 (0 .1 86) 4 .6 (2 .1) 20 1 .6 19 30 13 0 21. 13 (24.3) 22 .14 ( 26. 4) 29853 ⁄ 15 56 28.39 0.005 415 1. 367 07 Crystallographic ... planes ofthe bonds between Trp 215 –Gly2 16 and Cys1 91 Gln192 sandwich the phenyl ring of benzamidine The DESC1 S1 pocket resembles the thrombin S1 pocket type because ofthe presence of an Ala rather ... [1, 2 ,10 ] S1 The following segments border the S1-specificity pocket of DESC1: Asp189–Gln192 (the basement ofthe pocket), Ser 214 –Gly 219 (the entrance frame), Lys224– Tyr228 (the back ofthe pocket)...
... with the Nd atom of His12, one ofthe Od atoms of Asp15 and the Ne atom of His 113 His 113 protrudes from helix a4 whereas His12 and Asp15 both belong to the loop which joins the b1strand with the ... Ile18, Ile149, Leu172, Phe179 and the aromatic ring of Tyr194 The side chains of Tyr194, Asn150 and Asp108 form a hydrophilic patch close to the zinc ion and to the His 110 ⁄ Asp 112 pair This position, ... with the same residues coordinating a zinc ion These residues plus an additional conserved motif (Fig 7B) in the immediate neighborhood ofthe active site (His 110 , Pro 111 , Asp 112 , His 113 in the...
... F1 56( 15 5)I,S,C; D157 (1 56) G,E; F158 (15 7)I; T159 (15 8) M,A; and G 16 2 ( 16 1 )R,W (here and in the discussion below, human numbering is given in parentheses) F1 56( 15 5), D157 (1 56) , and F158 (15 7) are conserved ... P153 and G 16 2 are buried in the protein core Also, F1 56, F158, and V 16 0 are tightly packed into the hydrophobic core ofthe domain On the other hand, residues D152, N154, D155, D157, and R 16 3 are ... charged arginines [or the bulky tryptophan in the case of G 16 2 ( 16 1 )W] is predicted to generate gross structural disturbance ofthe fold Likewise, as the side chains of F1 56( 15 5) and F158 (15 7) contribute...
... Glu43 Gly 36 O O O O O O Og O O Og O O O O O Og O O O O O O O O O O O O 0.7 96 6. 013 4 .17 7 3.958 2 .62 5 2. 262 2. 560 2.594 2.9 01 2.939 3.027 6. 594 0.247 5.443 3.853 0.377 0.793 4 .17 4 8 .10 7 1 .64 6 3.777 ... Superimposition ofthe backbones of 3egf and 1eph gave an rmsd of 0. 16 9 nm for residues 6 33 and 0. 16 5 nm for residues 32–47 The overall best structure from the chimera family was superimposed with a structure ... calculated structures also explain the large secondary structural shifts of Asn 16 bCH2 and Arg 41 gCH2, which Fig Stereo view oftheofthe 10 best chimera structures, superimposed using the backbones of...