... ). The renewed interest in examining the indications for BCG vaccination in the United States included consideration ofthe wide range of vaccine efficacies deter-mined by clinical trials and ... toexplore the sources ofthe heterogeneity inthe efficacy ofthe BCG vaccine reported in the individual studies. Using a model that included the geographic latitude of the study site andthe data ... resurgence inthe incidence of TB occurred inthe UnitedStates and included increases inthe number of TB cases among adults and children and outbreaks of multidrug-resistant TB (MDR-TB) involving...
... a role in managing chest pain from the point of entry, theymust acquire and demonstrate competence in diagnosing the complaint.Chest pain can have a multitude of etiologies, involves aninherently ... set of themes as reached via consensus.This process involved examining themes for commonal-ity, classifying them for uniformity, and then reachingagreement on the final list of six key themes. ... forchest pain will depend on the nature ofthe condition and the urgency ofthe situation, that the point of referral maydepend on the familiarity or relationship between the providers, and that the...
... long way in influencing the target market and marketing approach to drive the demand of organics. The second LDF 2 identified the person responsible for shopping andthe location ofthe consumer ... with information that has established the decline of agriculture generally inthe province. Inthe Ciskei, the second most preferred shopping place is the Grocery stores mentioned by 23.1% ofthe ... regression andthe standardized discriminant functions to analyze the resulting data. There is evidence of growing interest in organic products inthe province, with a sizeable proportion of respondents...
... points ofthe 11 basis-point decline in the average expense ratio of funds of funds over the period (labeled in Figure 13 as “Fall in expense ratios of individual funds”). By definition, the ... inflation by taking the fee breakpoints available in 2010 and multiplying by the Consumer Price Index in December 2000 and dividing by the Consumer Price Index in December 2010. 3 The front-end ... Trends inthe Fees and Expenses of Mutual Funds, 2010KEY FINDINGS »On average, fees and expenses incurred by investors in long-term mutual funds declined in 2010. Stock fund investors in 2010...
... percentage of the assets that the financial professional manages for an investor, rather than as a percent ofthe dollars initially invested. Over time, brokers and other financial professionals ... underlying funds in which it invests. Since 2005, the average expense ratio for investing in funds of funds has fallen 18 basis points. » The average expense ratio investors paid to hold either index ... including its investment objective, its level of assets, the average account balance of its investors, the range of services it offers, fees that investors may pay directly, and whether the...
... the majority of rain during the Southwest monsoon. Generally, the quantity of rainfall decreases with increasing distancefrom the sea, but the amount of rainfall andthe length of rainy season ... plantation were interviewed in Thai with the help of a translator. The basic information of planted clone, area of plantation and age ofthe trees was obtained in thisway. In addition, information ... ResearchInstitute of Thailand (RRIT) andthe Office ofthe Rubber Replanting Aid Fund (ORRAF). The RRIT works under the Department of Agriculture (Ministry of Agriculture and Cooperatives), and its...
... asylum inthe UK has become increasingly controversial and emotive, successive governments have focused on reducing the number of asylum applications inthe UK and on increasing the number of asylum ... another and to make sure that they did not imbue the responses of interviewees with their own meaning and terminology. In some cases the interpreters had previously worked with the clients and ... though the resultant frameworks developed for charting and interpreting data were compared. Codes and frameworks were rooted inthe aims ofthe project and guided by the nature ofthe interview...
... state(disordered inthe ligand-free state in YbgJ). In the absence ofthe ligand, the lid part is separated from the active site, which leads to a more open active site.Upon the binding of ligand inthe ... sites of Mglu and Bacillus glutaminase inthe presence and absence of ligands. Backbone atoms ofthe seven conservedamino acid residues andthe three conserved tyrosine residues in Mglu and Bacillus ... conformations ofthe regions at100-105 and 303-309 aa inthe N form, and we investi-gated the following points. First, these areas are notinvolved in any contacts with other molecules in crys-tals...
... once into the idea ofthe children in regard to them, and treated them always as if theywere real persons; often speaking of them and to them, inthe presence ofthe other children, inthe mostserious ... all in his power to make the yoke of obedience light and easily to beborne.Influence on the healthful Development ofthe Brain.Indeed, besides the bearing of these views on the happiness ofthe ... for them to come simply because their motherCHAPTER IV. 20commands and signals, without being trained. In all these cases they perceive the necessity of training and instruction, and understand...
... Ponting CP (1998) Evidence that the conformation of unliganded human plasminogen ismaintained via an intramolecular interaction between the lysine-binding site of kringle 5 andthe N-terminalpeptide. ... effective in elevating Glu-plasminogen–fibrin binding. The actions of complestatin are canceled by a lysine analog. Thus, the target of complestatin is Glu-plasminogen, and the agent promotes its binding ... The surfactin Caction involves modulation of Glu-plasminogen activa-tion through relaxing the conformation ofthe protein.Surfactin C increases the intrinsic fluorescence of Glu-plasminogen, shortens...
... Ca2+.Removing the proposed Ca2+-coordinating residues in positions 1 and 3 ofthe EF-hand motif significantlycompromised the metal-binding capability ofthe engi-neered protein, indicating that the ... demonstratethat the conformation of CD2 is unchanged. After the insertion ofthe helix–loop–helix EF-hand domainfrom STIM1, the helical content ofthe engineeredprotein CD2.STIM1.EF increased, indicating ... grafting approach to address thisquestion. As shown in Fig. 1B, the distance between the two termini ofthe inserted Ca2+-binding sites in the model structure ofthe EF-hand of STIM1 is within15...
... represents an intermediate in processing.These findings indicate that the processing of pro-CPAoccurs in (at least) two steps, and that the processing of the intermediate form of CPA to mature ... Both the kinetics of accumulation andthe level of maximal storage werevirtually identical in SG+ ⁄ + and SG– ⁄ – cells, indica-ting that the storage of b-hexosaminidase is independ-ent of ... on serglycin. Together,these findings indicate that the reduced amounts of neutral proteases in the absence of serglycin is not caused by missorting into the constitutive path-way of secretion,...