re 1 silencing transcription factor rest regulation of neuronal gene expression via modification of the chromatin structure
Báo cáo sinh học: " Repressor element-1 silencing transcription factor/neuronal restrictive silencer factor (REST/NRSF) can regulate HSV-1 immediate-early transcription via histone modification" pptx
... was reduced in the presence of REST/ NRSF These results demonstrate the roles of REST/ NRSF in the regulation of HSV1 IE transcription Results A putative RE- 1/ NRSE was found within the promoter of ... HSV -1 RE- 1/ REST/ NRSF recruited corepressor CoREST to HSV1 RE- 1/ NRSE and induced histone H4 deacetylation A Over -expression of REST/ NRSF in 293HEK cells by transfection of pFLAG -REST Lane 1: 293HEK ... multiplicities of infection (MOI) Our results revealed that CoREST is recruited to HSV -1 RE- 1/ NRSE in the presence of REST/ NRSF, supporting the hypothesis that REST/ CoREST complexes participated in the regulatory...
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Báo cáo khoa học: Transcriptional activity and Sp 1⁄3 transcription factor binding to the P1 promoter sequences of the human AbH-J-J locus docx
... Probe Sp regulation of the AbH-J-J locus P1 promoter In order to further confirm the role of Sp1-related proteins in the transcription regulation of the AbH-J-J locus, a transcription factor decoy ... define the splicing events (Fig 1) as well as the structure of the 5¢-region of this locus [1] The data obtained indicate that the use of different splice donors is involved in the generation of ... sites The 5¢-end nucleotide positions of the progressively deleted promoter sequence present in the reporter constructs are shown in gray (B) Schematic representation of the ) 512 ⁄ + 11 2 region of...
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báo cáo khoa học: " An R2R3 MYB transcription factor associated with regulation of the anthocyanin biosynthetic pathway in Rosaceae" pptx
... leaves of red-osier dogwood Plant Physiol 20 01, 12 7(2):566-574 Lin-Wang et al BMC Plant Biology 2 010 , 10 :50 http://www.biomedcentral.com /14 71- 2229 /10 /50 10 11 12 13 14 15 16 17 18 19 20 21 22 ... Figure 7) Expression of an R2R3 MYB repressor of anthocyanin biosynthesis, FaMYB1 [19 ] was also examined in the same fruit series There was a large increase in the relative transcript levels of the ... and the heterozygous R1 and R6 alleles (Figure 1B) If MYB1 and MYB10 were different genes, band intensity ratios of 3 :1 would be possible but as only 1: 1 ratios are observed, MYB1 and MYB10 are...
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SERUM RESPONSE FACTOR-DEPENDENT REGULATION OF SMOOTH MUSCLE GENE TRANSCRIPTION
... differentiation The most highly studied microRNAs in smooth muscle are microRNA -14 3 (miR -14 3) and miR -14 5 [11 5 ,11 6 ,11 7 ,11 8 ,11 9] The miR -14 3 and miR -14 5 are two mature microRNAs that arise from the ... 10 0 Figure 16 10 2 Figure 17 10 4 Figure 18 10 6 Figure 19 10 7 Figure 20 10 9 Figure 21 11 1 ix LIST OF TABLES ... AND FUTURE STUDIES 11 5 A CArG-dependent regulation of smMLCK 11 5 B Transcriptional and epigenetic regulation of microRNAs in SMC .11 7 C Overall summary .12 1 REFERENCES ...
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Tài liệu Báo cáo khoa học: Regulation of the members of the mammalian heat shock factor family doc
... development, the trimeric form of HSF4 increases, while the levels of HSF1 and HSF2 are reduced [10 2] In the olfactory epithelium of 3–6-week-old mice, the expression profile of HSF1 remains constant ... by temperature shock and DNP in Drosophila Experientia 18 , 5 71 573 Lindquist S (19 86) The heat-shock response Annu Rev Biochem 55, 11 51 11 91 FEBS Journal 277 (2 010 ) 412 6– 413 9 ª 2 010 The Authors ... which they are regulated Albeit they all recognize and bind HSEs, the Regulation of HSFs HSFs regulate different types of target genes that are involved in a broad range of cellular processes Therefore,...
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Báo cáo khoa học: Calmodulin-mediated regulation of the epidermal growth factor receptor doc
... CM, Revankar CM, Deb TB, Dickson RB & Johnson MD (2009) Calmodulin modulates Akt Calmodulin and the EGFR 10 5 10 6 10 7 10 8 10 9 11 0 11 1 11 2 11 3 11 4 11 5 FEBS Journal 277 (2 010 ) 327–342 ª 2009 The ... disrupt the interaction of the JM region with another non-identified region in the receptor [67] The non-identified region of the receptor to which the JM region might bind could correspond to the ... Fiore PP (19 91) The juxtamembrane regions of the epidermal growth factor receptor and gp185erbB)2 determine the specificity of signal transduction Mol Cell Biol 11 , 319 1–3202 64 Sorokin A (19 95)...
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Báo cáo khoa học: Mitochondrial transcription factor A overexpression and base excision repair deficiency in the inner ear of rats with D-galactose-induced aging pdf
... analysis of Pol-c and OGG1 protein expression in the inner ear (A) Representative western blots show the expression levels of TFAM in different groups (B) The relative abundance of Pol-c and OGG1 protein ... Biol Rep, doi: 10 .10 07/s 110 33- 010 -0476-5 FEBS Journal 278 (2 011 ) 2500–2 510 ª 2 011 The Authors Journal compilation ª 2 011 FEBS Y Zhong et al 12 Kang D, Kim SH & Hamasaki N (2007) Mitochondrial transcription ... 2 011 FEBS Y Zhong et al mitochondrial D-loop region is rarely deleted, and the copy number of this region therefore serves as a measure of the total amount of mtDNA in a given tissue sample The...
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Báo cáo khoa học: A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-jB pathway in skeletal muscle pdf
... before amino acid 71, the region of cleavage would be between amino acids 65 and 71 Considering the location of the N-terminal extremity of DNter2 on the structure of CARP and the presence of the ... physiological processes: the orchestration of sarcomere remodeling [10 12 ], the control of apoptosis [9 ,13 ] and the regulation of gene expression [2,7–9] Calpain is found in several different subcellular ... (DARP), grouped together with respect to their common minimal structure and their potential role in the control of transcription [17 ,19 – 21] Although the three MARPs are expressed in both heart...
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Báo cáo khoa học: The C-terminal region of the proprotein convertase 1⁄ 3 (PC1⁄ 3) exerts a bimodal regulation of the enzyme activity in vitro pdf
... and are secreted upon stimulation of the cells Interestingly, it has been reported previously that no enzyme activity resulting from the PC1 ⁄ 66 kDa form could be recovered from the medium of ... frugiperda (Sf)9 cells expressing the recombinant mPC1 ⁄ 3, the presence of the 87 kDa form in excess of the 66 ⁄ 71 kDa facilitates isolation of the enzyme and helps in maintaining the enzymatic activity ... identification of a decapeptide present in the PC1 ⁄ CTpeptide The amount of the corresponding peptide, GVEKMVNVVE, located at the extreme N-terminus of the CT-peptide is reduced 10 -fold in extracts...
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Báo cáo y học: "Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes" pps
... citation purposes) Arthritis Research & Therapy 10 11 12 13 14 15 16 17 18 19 20 21 Vol No Hammaker et al Mor A, Abramson SB, Pillinger MH: The fibroblast-like synovial cell in rheumatoid arthritis: ... arthritis and its regulation by IL -1 and tumor necrosis factor- alpha J Immunol 19 91, 14 6:3365-33 71 Vincenti MP, Brinckerhoff CE: Transcriptional regulation of collagenase (MMP -1, MMP -13 ) genes in arthritis: ... (FLSs) were stimulated with IL -1 (2 ng/ml) for 24 h and MMP3 gene expression was assayed and normalized to GAPDH Data are shown as relative expression units (REU) IL -1 -induced MMP3 gene expression...
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báo cáo khoa học: " Identification of a GCC transcription factor responding to fruit colour change events in citrus through the transcriptomic analyses of two mutants" potx
... 2 010 , 10 :276 http://www.biomedcentral.com /14 71- 2229 /10 /276 CI (10 00·a/L·b) A Relative expression B Page 11 of 14 -5 -10 GA3 -15 -20 -25 2,5 1, 5 GA3 0,5 1- Sep 1- Oct 31- Oct 30-Nov Figure Effect of ... 0 .1 0.6 ± 0.3 0.5 ± 0.2 0.2 ± 0 .1 b-Cryptoxanthin 6 .1 ± 0.7 10 .3 ± 0.7 14 .1 ± 1. 2 11 .1 ± 2.3 15 .1 ± 0.5 13 .5 ± 2.0 Zeaxanthin Anteraxanthin 1. 7 ± 0 .1 5.6 ± 0 .1 2 .1 ± 0 .1 8.0 ± 0.5 2.3 ± 1. 3 10 .6 ... CX2904 91 C02024G06 PDR6 ABC transporter CX300782 C08002B 11 no annotation available CX298347 CX298349 C06 011 C03 C06 011 C05 Nitrate transporter NRT1-2 T23G18.9 CX3 014 11 CX3 015 71 C08009D08 C08 011 C 01 At1g62790...
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Báo cáo y học: "Baicalein inhibits IL-1β- and TNF-α-induced inflammatory cytokine production from human mast cells via regulation of the NF-κB pathway" pot
... IL-8 expression were 0.76 and 0.79 for the IL -1 and the IL -1 plus BAI groups, respectively, while that for MCP -1 expression were 0.74 and 0. 71 for the IL -1 and the IL -1 plus BAI groups, respectively ... http://www.clinicalmolecularallergy.com/content/5 /1/ 5 20 21 22 This work was supported in part by The Ruth R Harris endowment, and Research Development Committee of ETSU 23 References 10 11 12 13 14 15 16 17 18 19 Krishnaswamy ... 4analysis of effects of BAI on the gene expression of IL-6, IL-8, and MCP -1 in IL -1 - and TNF-α-activated HMC -1 cells RT-PCR RT-PCR analysis of effects of BAI on the gene expression of IL-6, IL-8,...
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Molecular function and regulation of the bax associating protein MOAP 1
... MITOCHONDRIA 14 1. 3 .1 Discovery of Bcl-2 as an oncogene 14 1. 3.2 The Bcl-2 family 16 1. 3.2 .1 Bcl-2 homolog (BH) domains 16 1. 3.2.2 Three classes of the Bcl-2 family 18 1. 3.2.3 Models for the functional ... HCT 116 cells are resistant to recombinant Bax- or tBid-mediated release of cytochrome c Figure 3 .1. 12 Stable expression of MOAP -1 rescues the phenotypes associated with MOAP-1knockdown xii Figure ... a variety of death-signals Figure 1. 15 The structures of the Bcl-2 proteins show a striking similarity to the pore-forming domains of bacterial colicins Figure 1. 16 Comparison of pore-forming...
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Reactive oxygen species mediated regulation of the na+ h+ exchanger, NHE 1 gene expression a new mechanism for tumor cells resistance to apoptotic cell death
... IV .12 Regulation of intracellular pH as one of the mechanisms of 11 3 NHE -1- mediated cell survival IV .13 Region of NHE -1 promoter involved in O2. mediated activation 11 5 IV .14 Conclusions 11 6 ... correlates with the amount of NHE -1 protein expression on the cell surface Moreover, down -regulation of NHE -1 gene expression in tumor cell lines tested reverted their resistant phenotype These ... 48 III .1. a Regulation of NHE -1 gene expression regulates cells’ response 48 to death triggers in NIH3T3 cells III .1. b Regulation of NHE -1 gene expression regulates cells’ response 52 to death...
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Tài liệu Báo cáo khoa học: The Arabidopsis protein kinase Pto-interacting 1-4 is a common target of the oxidative signal-inducible 1 and mitogen-activated protein kinases docx
... were further analysed (Fig 1B) Three of the prey cDNAs encoded two other FEBS Journal 278 (2 011 ) 11 26 11 36 ª 2 011 The Authors Journal compilation ª 2 011 FEBS 11 27 pBD-OXI1 pBD-OXI1 pBD pBD-OXI1 ... Grierson FEBS Journal 278 (2 011 ) 11 26 11 36 ª 2 011 The Authors Journal compilation ª 2 011 FEBS C Forzani et al 10 11 12 13 14 15 16 17 18 CS, Hirt H et al (2004) OXI1 kinase is necessary for oxidative ... signaling in Arabidopsis Mol Cell 15 , 14 1 15 2 FEBS Journal 278 (2 011 ) 11 26 11 36 ª 2 011 The Authors Journal compilation ª 2 011 FEBS 11 35 PTI1-4, a common target of OXI1 and MAPKs C Forzani et al 34...
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Tài liệu REGULATION OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL doc
... total not exceed a threshold of EUR 500 million In order to make the calculation of this threshold 13 OJ L 302, 17 .11 .2009, p 32 OJ L 17 4, 1. 7.2 011 , p .1 14 EN 11 EN operational, the power to adopt ... (d) of Article 13 (1) of the removal of the venture capital fund manager from the register referred to in point (b) of paragraph of this Article The right to market one or more qualifying venture ... established in the Union and are registered with the competent authority in their home Member State in accordance with Directive 2 011 / 61/ EC of the European Parliament and of the Council of June 2 011 on...
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Tài liệu Báo cáo khoa học: Regulation of the actin–myosin interaction by titin doc
... and remained in the pellet independently of the other components and the ionic strength of the mixture In the presence of ATP, the amount of bound HMM was very similar (average value of 52.5 ± 1. 1%) ... muscles which are heterogeneous in their fibre-type content [59] Nevertheless, both the homogeneity of the T800 preparation and the results of the mass peptide analysis suggest that the proteolysis ... mediated by the PEVK domain Another actin-binding site candidate was proposed within stretch of residues 17 91 212 6 of cardiac titin [ 31] , but we are still not certain whether this stretch of residues...
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Tài liệu Báo cáo Y học: Presence and regulation of the endocannabinoid system in human dendritic cells potx
... intense immunoreactive band at 61. 5 kDa To examine the modulation of CB1, CB2 and FAAH mRNA expression in immature vs mature dendritic cells, we compared the expression of these genes by RT-PCR ... determine the presence of the corresponding proteins Using specific primers for human CB1, amplification of immature and mature dendritic cell cDNA revealed the presence of mRNA transcripts of the expected ... dehydrogenase and FAAH were selected on the basis of the sequence of the FAAH gene (NCBI accession number AF098 010 ) by including the introns 5476–6026 and 617 3–6296, and of the sequence of the glyceraldehyde-3-phosphate...
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Báo cáo khoa học: Protein transport in organelles: The composition, function and regulation of the Tic complex in chloroplast protein import pptx
... which anchor the protein in the membrane The position and function of the long C-terminal tail on the other hand remains a matter of controversy [10 ,11 ,13 15 ] According to one hypothesis, the hydrophilic ... Tic 110 -Ct faces the stroma, where it functions as a scaffold for the organization of the stromal processes occurring during import [10 ,13 ,14 ] These include the recruitment of chaperones to the ... knockouts were albino even in the youngest 11 68 parts of the seedling [19 ,20] The presence of at least one other Tic20 isoform (AtTic20-IV) may prevent attic20-I plants from lethality Two more isoforms...
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