... structural domains, while proCPY would be composed of a single fragile domain The propeptide ofthe proenzyme would be located at the interface ofthe two domains thus combining them into one body, ... Structural properties of mature form (CPY) As far as can be seen inthe experiments involving the stepwise increase in temperature and pressure, the heatinduced unfolding of CPY and Dgly CPY showed ... cleft ofthe active site will be located inthe interface between the two structural domains of CPY and would be filled by the propeptide, thus uniting the two domains in a body, as if the entire...
... role in stabilizing the proteinprotein interface [31] All ofthe interactions reported in Fig inthe range between and 6.0 A are identical inthe major and minor fractions ofthe holoprotein in ... between the two proteins (as indicated by the values of DGwater, Cm and Tg) hence arise from the changes inthe surface ofthe protein because ofthe interactions ofthe cofactor with the protein ... chaotrope-induced unfolding was almost fully reversible in both forms ofthe protein Removal ofthe perturbation makes the protein regain its native formThe unfolding reactions of both forms are...
... targeting as well For many proteins imported into mitochondria, the pI ofthe mitochondrial formofthe protein is higher than that ofthe cytosolic protein form [65,66] It will be surprising if the ... replication ofthe leading strand was thought to begin first, producing an expanding displacement (D)-loop prior to the initiation of lagging strand synthesis Instead, synthesis of leading and lagging strands ... proteins and DNA binding proteins from the mtDNA These proteins (now soluble) are recovered inthe supernatant following centrifugation ofthe high salt extract at 30 000 g for 30 In contrast, the...
... (figure 1) In anticipation ofthe difficulties expected in manipulating the left end hairpin and to increase the chances of obtaining the desired construct two copies ofthe left end termini were ... length molecule of ~806 bp (step 5) As a result of replication, the arrangement ofthe arms inthe hairpin change resulting in hairpins with the GAG triplet present at the 5'end ofthe molecules ... structures ofthe hairpin inthe flip conformation The expected fragments for the digestion ofthe flip and flop conformations ofthe left hairpin are very similar in size, any slight variation in migration...
... (figure 1) In anticipation ofthe difficulties expected in manipulating the left end hairpin and to increase the chances of obtaining the desired construct two copies ofthe left end termini were ... length molecule of ~806 bp (step 5) As a result of replication, the arrangement ofthe arms inthe hairpin change resulting in hairpins with the GAG triplet present at the 5'end ofthe molecules ... structures ofthe hairpin inthe flip conformation The expected fragments for the digestion ofthe flip and flop conformations ofthe left hairpin are very similar in size, any slight variation in migration...
... three kinds of distorted spectra and for several choices ofthe redshift of heating, zh, i.e for the corrisponding value of y~ indicated inthe top panel Inthe two first cases the energy is injected ... energy injected inthe radiation field (ei being the radiation energy density before the heating) The above formulae are a rather accurate description of numerical calculations, inthe hypothesis of ... Ae/e) includes the effect of relativistic neutrinos on the expansion time in presence of energy injected inthe radiation field (for species of massless neutrinos, ~ = 1.68) On the other hand the...
... (certain) Travel is said to the mind (broad) Maradona is one ofthe best football inthe world (play) The town is situated on the river (attract) How can you imagine theof mathematics in our ... She is thinking of English (study) Do you like to solve puzzles? (mathematics) The to the problems will be difficult to find (solve) He is the most pupil in our class (intelligence) The company ... Daisy has been out of work for months She stays at home and does the housework A) disappoint B) disappointed C) disappointing D) disappointedly The fight against the _of our environment...
... ) in Ha Noi The plane ( stop) at a small town It then (take ) off immediately after refuelling 10 She (be ) so happy when she (hearn ) the news that she ( cry ) V supply the correct verbs form ... ( finish ) lunch I ( hope ) it ( stop ) raining by o’clock this afternoon The river ( not begin ) to swell until some rain ( fall ) By next month , I ( leave ) for India The film ( end ) by the ... during winter 67 I ( finish) the book before my next birthday 68 John ( watch ) TV at last evening 69 Mr Pike ( live )here since last October 70 Someone ( cut ) down all the trees in the...
... imaging ofthe wrist; contrast injection; enhanced imaging ofthe wrist; the patient was repositioned so that the fingers were within the coil; and then enhanced imaging ofthe fingers was performed ... definition of arthritis mutilans Clinical digitised photographs ofthe hands and feet were obtained in 25 ofthe 28 patients These were examined by a rheumatologist (ND) blinded to the results of radiography ... Details of sequences and acquisitions are shown in Table The sequence of imaging was as follows: unenhanced imaging ofthe fingers; the patient was repositioned so that the wrist was within the coil;...
... activity decreased inthe previous leaf and the highest enzyme activity was found again inthe new leaf (Fig 2) When the nitrate supply was withdrawn, the enzyme activity recovered its minimum value ... Effect of nitrate of leaf NR activity of nodulafed plants Administration of mM NaN0 to 11 mo old nodulated plants did not increase leaf NR activity, whereas the 10 mM NaN0 dose induced high ... nmol N02-mg- measured in vivo inthe leaves of young nitrogen-deficient R pseudoacacia; its role is unknown, but its decrease, concomitant with the advent ofthe N activity, indicates a relationship...
... imaging ofthe wrist; contrast injection; enhanced imaging ofthe wrist; the patient was repositioned so that the fingers were within the coil; and then enhanced imaging ofthe fingers was performed ... definition of arthritis mutilans Clinical digitised photographs ofthe hands and feet were obtained in 25 ofthe 28 patients These were examined by a rheumatologist (ND) blinded to the results of radiography ... Details of sequences and acquisitions are shown in Table The sequence of imaging was as follows: unenhanced imaging ofthe fingers; the patient was repositioned so that the wrist was within the coil;...
... to explain the absence of mutations in our cohorts is the lack of influence ofthe PINK1 gene inthe pathogenesis of late-onset PD Individual tagging SNPs and tag-defined haplotypes in 500 PD ... serine-threonine kinase domain with homology to kinases ofthe Ca2+/calmodulin family[3] It appears to exert protective effects against cellular stress within mitochondria[3] These findings link ... that the Q115L variant was not associated with late-onset PD in our study These findings correspond to previously published data of no leading association of other coding SNPs within the PINK1...
... exceeds the cost ofthe activities, thereby resulting in a profit margin The primary value chain activities are: Inbound Logistics: the receiving and warehousing of raw materials and their distribution ... create the scientific basis for establishing the contents of implementing marketing plan in after, the thesis focus on analyze the main factors inthe marketing program through distinguish the marketing ... objective, the board of leader must decide the combine marketing and other fields in efficiently 34 - Having department of collecting, analyzing information in timely and accurately The researches...
... centuries ago The countryside inthe area is ( charm) and most ofthe buildings there ear made from an( attract) of light stone that is particular to the Cotswold’s Inthe summer, the Cotswold’s ... help) against such abuse 56 His ( inform) were middle- class professional women 57.Only the snores ofthe ( sleep) broke the silence ofthe house 58 His landlady was a kind( home) ... of ( differ) between liking someone and loving them 25 She had never been greatly concerned about her( appear) 26 For further( inform) on the diet, write to us at this address 27 The...
... "I" needs the first singular verbform "am", and the subject ofthe third singular person "he" requires the third singular verbform "is" It is said that the different forms oftheverb "be"agree ... "including", theformoftheverb depends on the 1st element preceding these connectors If it is singular, theverb is singular too If it is plural, it requires a plural formoftheverb E.g: a The actor, ... require singular verbs But the plural forms "people" and "them" inthe "of- phrase" influence theformofthe nearby verbThe opposite phenomenon , singular attraction, is observed in example...
... but the fact is that he isn't here 12 I have never met her before in my life Why is she looking at me as if she knew me? 13 If I were a bird, I wouldn't want to live in a snake 14 My brother ... (be) hear but the fact is that he isn't here.were 12 I have never met her before in my life Why is she looking at me as if she (know) me?knew 13 If I (be) a bird, I (not,want) to live in a snake.were ... a snake.were / wouldn't want 14 My brother managed to kill the snake just at the time when I (be) almost exhausted If he (be) a little late, I (kill) by the snake.was / had been / would have...