principles of clinical pharmacology ppt
Chapter 005. Principles of Clinical Pharmacology (Part 2) ppt
... P-glycoprotein, the product of the normal expression of the MDR1 gene. P-glycoprotein is expressed on the apical aspect of the enterocyte and on the canalicular aspect of the hepatocyte (Fig. 5-3); ... from the site of administration (Fig. 5-2). The extent of absorption may be reduced because a drug is incompletely released from its dosage form, undergoes destruction at its site of administration, ... aInhibitors affect the molecular pathway, and thus may affect substrate. bClinically important genetics variants described. A listing of CYP substrates, inhibitors, and inducers is maintained at http://medicine.iupui.edu/flockhart/table.htm....
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PRINCIPLES OF CLINICAL PHARMACOLOGY Second Edition potx
... basic principles of clinical phar-macology currently are being applied in the process of drugdevelopment.Journals Clinical Pharmacology and TherapeuticsBritish Journal of Clinical Pharmacology Journal ... effective use of medicine can be traced back at least to RudolphBucheim (1820–1879), who has been credited with1 PRINCIPLES OF CLINICAL PHARMACOLOGY, SECOND EDITION20 Principles of Clinical Pharmacology Therefore, ... 6 Principles of Clinical Pharmacology TABLE 1.1 Status of Renal Function in 44 Patients withDigoxin ToxicityaSerum creatinine(mg/dL)No. of patients with CLCR of Percentage of group50...
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Chapter 005. Principles of Clinical Pharmacology (Part 1) pps
... Chapter 005. Principles of Clinical Pharmacology (Part 1) Harrison's Internal Medicine > Chapter 5. Principles of Clinical Pharmacology Principles of Clinical Pharmacology: Introduction ... accompaniment of drug therapy, this is not the case. The goal of this chapter is to describe the principles of clinical pharmacology that can be used for the safe and optimal use of available ... of the target molecule itself or of variability in the broad biologic context in which the drug-target interaction occurs to achieve drug effects. Two important goals of the discipline of clinical...
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Chapter 005. Principles of Clinical Pharmacology (Part 3) docx
... intravenous infusion, plasma concentrations at steady Chapter 005. Principles of Clinical Pharmacology (Part 3) Clinical Implications of Altered Bioavailability Some drugs undergo near-complete ... a typical intravenous dose of verapamil is 1–5 mg, compared to the usual single oral dose of 40–120 mg. Administration of low-dose aspirin can result in exposure of cyclooxygenase in platelets ... tissues, the volume of distribution can be far greater than any physiologic space. For example, the volume of distribution of digoxin and tricyclic antidepressants is hundreds of liters, obviously...
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Chapter 005. Principles of Clinical Pharmacology (Part 4) ppsx
... Chapter 005. Principles of Clinical Pharmacology (Part 4) Clinical Implications of Drug Distribution Digoxin accesses its cardiac site of action slowly, over a distribution phase of several ... volume of distribution of lidocaine is reduced. Therefore, lower-than-normal loading regimens are required to achieve equivalent plasma drug concentrations and to avoid toxicity. Rate of Intravenous ... prevent elimination by very rapid (t1/2 of seconds) uptake into erythrocytes and endothelial cells before the drug can reach its clinical site of action, the atrioventricular node. Plasma...
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Tài liệu Principles of Public Speaking ppt
... 30-Jan Interviews, a preparation for Speech of Introduction A, J 2-Feb SPEECH OF INTRODUCTION S, F 4-Feb SPEECH OF INTRODUCTION S, F 6-Feb SPEECH OF INTRODUCTION S, F, J 9-Feb Organizing the ... incorporate each of the previous speaking purposes, with the additional task of cooperating in a team of approximately 4 to craft an extended presentation (no more than 45 minutes) on a topic of your ... outside of our class and write a thoughtful critique of the speaker. In 2-3 pages, you should discuss topics such as the strengths and limitations of the speaker’s style, organization of content,...
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Tài liệu OECD Principles of Corporate Governance ppt
... Part Two Annotations to the OECD Principles of Corporate Governance 9 © OECD 2004 OECD Principles of Corporate Governance The OECD Principles of Corporate Governance were originally ... board, subject to the approval of the shareholders. Some companies issue preferred (or preference) shares which have a preference in respect of receipt of the profits of the firm but which normally ... support the exercise of entrepreneurship and limit the risks of damaging conflicts of interest in both the private sector and in public institutions. OECD PRINCIPLES OF CORPORATE GOVERNANCE...
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Tài liệu OECD Principles of Corporate Governance pptx
... 92-64-01597-326 2004 02 1 POECD Principles of CorporateGovernanceOECD Principles of Corporate GovernanceSince they were issued in 1999, the OECD Principles of Corporate Governancehave gained ... corporate officers may not only violate the rights of stakeholders but also be to the detriment of the company and its shareholders in terms of reputation effects and an increasing risk of future ... board. Each of the sections is headed by a single Principle that appears in bold italics and is followed by a number of supporting sub -principles. In the second part of the document, the Principles...
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principles of economics 2012 pptx
... of income, in-cluding compensation of employees, corporate profits, and so on. A slice of the pierepresents each source’s share of the total. The bar graph in panel (b) compares ameasure of ... I’ll produce 24 pounds of meat and 2 pounds of potatoes. After I give you 3 pounds of meat in exchange for 1 pound of potatoes, I’ll have 21 pounds of meat and 3 pounds of potatoes. Inthe end, ... less of the other. When the economy moves frompoint A to point C, for instance, society produces more computers but at the ex-pense of producing fewer cars.Another of the Ten Principles of Economics...
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Handbook of Clinical Neurology pptx
... BreezeDepartment of Neurosurgery, University of ColoradoSchool of Medicine, Denver, CO, USAC. Brefel-CourbonDepartment of Clinical Pharmacology, Clinical Investigation Centre and Department of Neurosciences, ... RabeyDepartment of Neurology, Assaf Harofeh MedicalCenter, Zerifin, IsraelA. RajputDivision of Neurology, Department of Medicine,University of Saskatchewan, Saskatoon, SK, CanadaA. H. RajputDivision of ... RaoDepartment of Neurology, Louisiana State UniversityHealth Sciences Center, New Orleans, LA, USAO. RascolDepartment of Clinical Pharmacology, Clinical Investigation Centre and Department of Neurosciences,...
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