principles of clinical pharmacology ebook
PRINCIPLES OF CLINICAL PHARMACOLOGY Second Edition potx
Ngày tải lên :
22/03/2014, 23:20
... basic principles of clinical phar-
macology currently are being applied in the process of drug
development.
Journals
Clinical Pharmacology and Therapeutics
British Journal of Clinical Pharmacology
Journal ... effective use of
medicine can be traced back at least to Rudolph
Bucheim (1820–1879), who has been credited with
1
PRINCIPLES OF CLINICAL PHARMACOLOGY, SECOND EDITION
20 Principles of Clinical Pharmacology
Therefore, ... 6 Principles of Clinical Pharmacology
TABLE 1.1 Status of Renal Function in 44 Patients with
Digoxin Toxicity
a
Serum creatinine
(mg/dL)
No. of patients with CL
CR
of
Percentage of
group
50...
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Chapter 005. Principles of Clinical Pharmacology (Part 1) pps
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06/07/2014, 08:20
... Chapter 005. Principles of Clinical
Pharmacology
(Part 1)
Harrison's Internal Medicine > Chapter 5. Principles of Clinical
Pharmacology
Principles of Clinical Pharmacology: Introduction ... accompaniment of drug
therapy, this is not the case. The goal of this chapter is to describe the principles of
clinical pharmacology that can be used for the safe and optimal use of available ... of the target molecule itself or of variability in the broad biologic context
in which the drug-target interaction occurs to achieve drug effects.
Two important goals of the discipline of clinical...
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Chapter 005. Principles of Clinical Pharmacology (Part 2) ppt
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06/07/2014, 08:20
... P-glycoprotein, the product of the
normal expression of the MDR1 gene. P-glycoprotein is expressed on the apical
aspect of the enterocyte and on the canalicular aspect of the hepatocyte (Fig. 5-3); ... from the site of administration (Fig. 5-
2). The extent of absorption may be reduced because a drug is incompletely
released from its dosage form, undergoes destruction at its site of administration, ...
a
Inhibitors affect the molecular pathway, and thus may affect substrate.
b
Clinically important genetics variants described.
A listing of CYP substrates, inhibitors, and inducers is maintained at
http://medicine.iupui.edu/flockhart/table.htm....
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Chapter 005. Principles of Clinical Pharmacology (Part 3) docx
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06/07/2014, 08:20
... intravenous infusion, plasma concentrations at steady
Chapter 005. Principles of Clinical
Pharmacology
(Part 3)
Clinical Implications of Altered Bioavailability
Some drugs undergo near-complete ... a typical intravenous dose of verapamil is 1–5 mg, compared
to the usual single oral dose of 40–120 mg. Administration of low-dose aspirin can
result in exposure of cyclooxygenase in platelets ... tissues, the volume of distribution can be far greater than
any physiologic space. For example, the volume of distribution of digoxin and
tricyclic antidepressants is hundreds of liters, obviously...
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Chapter 005. Principles of Clinical Pharmacology (Part 4) ppsx
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06/07/2014, 08:20
...
Chapter 005. Principles of Clinical
Pharmacology
(Part 4)
Clinical Implications of Drug Distribution
Digoxin accesses its cardiac site of action slowly, over a distribution phase
of several ... volume of distribution of lidocaine is reduced. Therefore, lower-than-
normal loading regimens are required to achieve equivalent plasma drug
concentrations and to avoid toxicity.
Rate of Intravenous ... prevent elimination by
very rapid (t
1/2
of seconds) uptake into erythrocytes and endothelial cells before
the drug can reach its clinical site of action, the atrioventricular node.
Plasma...
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Chapter 005. Principles of Clinical Pharmacology (Part 5) doc
Ngày tải lên :
06/07/2014, 08:20
... effect of the drugs, it may produce
severe agonist–mediated effects (such as hypertension or tachycardia) if the
blocking drug is abruptly withdrawn.
Chapter 005. Principles of Clinical
Pharmacology ... site of action, it alters the function of that
molecular target, with the ultimate result of a drug effect that the patient or
physician can perceive. For drugs used in the urgent treatment of ... accumulation of
active metabolites. Commonly, the clinical effect develops as a downstream
consequence of the initial molecular effect the drug produces. Thus, administration
of a proton-pump...
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CRC Desk Reference of Clinical Pharmacology SECOND EDITION doc
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06/03/2014, 14:20
... designation of Chester Fritz Distinguished
Professor of Pharmacology and of Clinical Neuroscience, the
highest honor bestowed by the University of North Dakota.
8 DESK REFERENCE OF CLINICAL PHARMACOLOGY
For ... July of 1999, he was appointed professor
and chairman of the Department of Pharmacology and Tox-
icology at the University of North Dakota School of Med-
icine and Health Sciences. In September of ... infringe.
Library of Congress Cataloging-in-Publication Data
Ebadi, Manuchair S.
Desk reference of clinical pharmacology / author, Manuchair Ebadi. 2nd ed.
p. ; cm.
Rev. ed. of: CRC desk reference of clinical...
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Toxicology and Clinical Pharmacology of Herbal Products pdf
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06/03/2014, 14:20
... toxicological analysis of biofluids, or the pharmacologic or toxicologic
effects of the herb, further investigation might prove difficult or impossible. Toxicology and Clinical
Pharmacology of Herbal Products ... effects of herbs can
be found.
Toxicology and Clinical Pharmacology of Herbal Products is designed to provide medical examiners,
toxicologists, and health care providers with an objective review of ... toxicology is an extension of pharmacology, but also to make the book
useful for a wide variety of applications by professionals with various interests. Adverse effects noted
in clinical trials are...
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Clinical Pharmacology of Sleep doc
Ngày tải lên :
22/03/2014, 23:20
... tendency to pick and choose their clinical subject matter
as it relates to their interest in specific conditions and their clinical pharmacology.
Clinical Pharmacology of Sleep is an important and ... can get. Several people were instrumental
in the production of this new volume of Clinical Pharmacology of Sleep.
The dedicated staff of Birkhauser-Verlag, Basel, Switzerland made this project
an ... him up.
– Ecclesiastes 4:9
Clinical Pharmacology
of Sleep
Edited by S.R. Pandi-Perumal and J.M. Monti
Birkh¨auser Verlag
Basel • Boston • Berlin
Neuropharmacology of obstructive sleep apnea and...
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The Great Ideas of Clinical Science 17 Principles That Every Mental Health Professional Should Understand pot
Ngày tải lên :
29/03/2014, 00:21
... Davison is professor and chair of the University of Southern
California’s Department of Psychology. In 2006 he served as president
of the Society of Clinical Psychology (Division 12 of APA) and ...
Distinguished Professor of Psychology and director of the Clinical
Research Unit at the University of Houston, where he also teaches in
the graduate clinical program. He has served on the boards of 7 ... is not a matter of logic, but a matter of judgment and
persuasion.) The “importance” of the results is also a matter of persua-
sion. For example, is the magnitude of the effect clinically significant?...
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