pathophysiology of skeletal muscle
Tài liệu Báo cáo khoa học: Effect of gadolinium on the ryanodine receptor/ sarcoplasmic reticulum calcium release channel of skeletal muscle docx
... Regulation of the rat sarcoplasmic reti-culum calcium release by calcium. J Muscle Res CellMotil 21, 131–138.20 Lai FA & Meissner G (1990) Structure of the calciumrelease channel of skeletal muscle ... presence of 18 nm ryanodineand the amount of ryanodine bound was plottedagainst the concentration of the gadolinium (Fig. 7).Fitting of data points with the Hill equation revealed aKdvalue of ... CoronadoR (1988) Ryanodine receptor of skeletal muscle is a gapjunction-type channel. Science 242, 99–102.13 Sitsapesan R & Williams AJ (1995) The gating of thesheep skeletal sarcoplasmic reticulum...
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Báo cáo khoa học: Cardiac ankyrin repeat protein is a marker of skeletal muscle pathological remodelling pot
... standardization of the loading. (D) Weights of injected TA muscles (n = 13) were compared to those of control samples. No significant difference wasobserved. (E) Histological analyses of muscles. Frozen ... obtain denervation of the muscle of the lower limb,the dorsal skin of the thigh of 2-month-old male129SvPasIco mice (n = 6 for each time point) was cut,and the posterior muscles were split ... waschecked at the time of muscle excision by visualization of abnormal gait of the limb and by verifying the disconti-nuity of the sciatic nerve at the thigh. The TA, EDL andsoleus muscles were sampled...
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Báo cáo khoa học: Mapping contacts between regulatory domains of skeletal muscle TnC and TnI by analyses of single-chain chimeras potx
... domain of TnC [33]. The crystal structure of cTn [20] showed that residues R117 to L128 of TnI (inchicken fast skeletal numbers) are in close contact withthe N domain of TnC in the presence of ... terminus of TnI has a tubular-like conformation that involves theglobular N domain of TnC. NMR studies have provi-ded additional information on the structure of skeletal TnC(1–91) in the presence of ... structure of TnI and TnC that can explainhow they interact during muscle contraction. Figure 6shows a schematic representation of the structural dis-position of TnC and TnI in the light of recent...
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Báo cáo Y học: Fluorescence study of the high pressure-induced denaturation of skeletal muscle actin pdf
... release of ADPdepolymerised actindenaturedactinrandom aggregationafter release of pressure[1][2][3]Fig. 12. Schematic interpretation of thebehaviour of F-actin in the presence of free ... 250 MPa.However, the increase of intensity of ¯uorescence of eATPbuffer itself was much smaller than that of eATP bo und toG-actin. Therefore, the increase of ¯uorescence seems to b edue ... thecentre of spectral mass of intrinsic ¯uorescence spectrum of G-actinwithATP(0.5mgámL)1, p H 7.5) in a pressurerange from 0.1 MPa to 400 MPa at a ®xed temperature of 20 °C. The transition of the...
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Tài liệu Báo cáo khoa học: Subproteomics analysis of Ca2+-binding proteins demonstrates decreased calsequestrin expression in dystrophic mouse skeletal muscle pdf
... viscosity of t he extract as a result of D NA, 2 lLofDNase I (200 units) was added per 100 lL of buffer [30].Following filtration through two layers of miracloth a nd theaddition of four volumes of ... usedwere of analytical grade and purchased from SigmaChemical Company.Preparation of total muscle extractsFor the comparative gel electrophoretic analysis of normalvs. dystrophic skeletal muscle ... analysis of Fig. 3 and the 1D i mmunoblotting of Fig. 4.As the full-length Dp427 isoform of dystrophin does notenter the second dimension of conventional 2D gels, theexpression level of a-dystroglycan...
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Báo cáo khoa học: Progressive decrease of phosphocreatine, creatine and creatine kinase in skeletal muscle upon transformation to sarcoma pot
... 4. Immunoblot of CK isoforms of different post-operativehuman tissues. (A) Immunoblot of MCK (a) and sMitCK (b) of nor-mal muscle (N) and fibrosarcoma (T) tissue. (B) Immunoblot of BCK(a) and ... Expression of mRNA of MCK and sMitCK isoforms of crea-tine kinase and b-actin in normal muscle (NM) and 3MC inducedsarcoma tissue (ST) of mouse.1.00.80.60.40.2Relative expression of mRNA0.0NMCK ... that because of the lowabundance of MCK and sMitCK isoenzymes insarcoma, a much higher amount of protein had to beapplied compared with normal muscle. Detection of BCK and uMitCK isoforms in...
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Báo cáo y học: "Skeletal muscle sodium glucose co-transporters in older adults with type 2 diabetes undergoing resistance training"
... support the postulated sensing activity of hSGLT3 [33] in skeletal muscle. However, the increased expression of hSGLT3 in skeletal muscle we found after 16 weeks of resistance exercise without a ... predictor of hSGLT3 transcript levels, explaining 68% of its variability (P=0.01). Our data show that hSGLT3, but not GLTU4, expression was enhanced in skeletal muscle after 16 weeks of resistance ... important factor. Exercise, the major physiological activator of muscle glucose transport, regulates the expression of GLUT4 in skeletal muscle [3, 4], and induces its translocation from the intracellular...
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Tài liệu Report on The Management of Non-Muscle-Invasive Bladder Cancer ppt
... TL,Catalona WJ. Long-term followup of patients treatedwith 1 or 2, 6-week courses of intravesical bacillusCalmette-Guerin: analysis of possible predictors of response free of tumor. J Urol 1990;144(3):652-7.Cordon-Cardo ... butmost recurrences of non -muscle- invasive bladdercancer (especially of initially diagnosed grade 1,stage Ta disease) are not muscle invasive and car-ry relatively little risk of metastasis or ... recur-rence of these tumors. There is no evidence thatany intravesical therapy affects the ultimate rate of progression to muscle- invasive disease. Because there is risk of progression to muscle- invasive...
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Tài liệu The pathophysiology of tuberculosis - Tuberculosis: back to basics ppt
... bythalidomideMoreiraetal.(1993)J.Exp.Med.177,16751680Theuse of IL4genekno ckou tBalb/cmicetolookattherole of IL4innecrosisan dfib rosisinpulmonaryTBHernan dezPandoetal (2004)EurJImmunol34,174183•Role of IL4innecrosisconfirmed•Whataboutfibrosis?Doeshu ... PeoplewithlatentTBwhodonotprogresstoactivediseasehaveincreasedexpression of anantagonist of IL4,kno wnasIL4d2• Asuccessfulvaccin emayneedto downregulatetheunwantedTh2(IL4)component,ratherthanincreasingTh1whichisrapidlyevokedby ... tedmacrophageIL4,IL5Th0TcyIL4easilydetectedbyELISAIL4notdetectedbyELISA;needRTPCR,orprestimulatedcellsandFACSIshi ghIL4inTBpatientsafeature of developingcountries?Rook,DhedaandZumla(2004),Vaccine,inpressLowlevels of IL4d2nowfoundinrodentsYatsenkoetalBullExpBiolMed2004;137:179IL4d2,competitive...
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Tài liệu Báo cáo khoa học: SREBPs: physiology and pathophysiology of the SREBP family ppt
... and pathophysiology of the SREBP familyFEBS Journal 276 (2009) 616–621 ª 2008 The Author Journal compilation ª 2008 FEBS 621SREBP-1c and lipogenesisThe SREBP family consists of three isoforms: ... summarize, SREBP-1c is a physiological regulator of lipogenesis, and activation of SREBP couldcontribute to obesity-related pathophysiology throughmodification of tissue-specific gene expression asshown ... exocytosis of insulin-containing gran-ules by uncoupling protein-2 through ATP consump-tion, and granuphilin through inhibition of the vesiclefusion machinery [29–31].Fatty acids as modulators of...
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Tài liệu Báo cáo khoa học: Thermal unfolding of smooth muscle and nonmuscle tropomyosin a-homodimers with alternatively spliced exons docx
... may also occur in nonmuscle Tmisoforms due to replacement of the N-terminal muscle exon 1a by nonmuscle exon 1b.The noncooperative unfolding of a significant part of the nonmuscle Tm molecule ... to isoform type. In mam-malian cells, alternative splicing produces a variety of muscle and nonmuscle isoforms from four differ-ent genes [1]. Muscle cells express two major iso-forms of Tm ... to investigate thermal unfolding of recombinant fibroblast isoforms of a-tropomyosin (Tm) in comparison with that of smooth muscle Tm.These two nonmuscle Tm isoforms 5a and 5b differ internally...
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Báo cáo khoa học: Equilibrium distribution of skeletal actin–tropomyosin– troponin states, determined by pyrene–tropomyosin fluorescence potx
... states of regulated actin are important determinants of the regu-lation of striated muscle contraction. The distribution of these states determines the ATPase activity, whereasthe rates of transitions ... troponin T,troponin I and troponin C, which bind along actin fila-ments of skeletal and cardiac muscles. Activation of striated muscle contraction occurs when Ca2+binds totroponin C, or in a Ca2+-independent ... reliable meth-ods of determining the state of actin in real time. Thismanuscript explores, in detail, a well-known method of monitoring the state of regulated actin.The fraction of actin in the...
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Muscle Growth GuideAuthor: Darren O ConnellBrought to you by http://www.explosivemusclegrowth.com.Muscle Growth GuideTable of Contents2 Muscle Building Secrets Guaranteed to Add Muscle Mass!.......................................................... pptx
... triceps.17 Muscle Growth GuideTable of Contents2 Muscle Building Secrets Guaranteed to Add Muscle Mass! 4Build Big Muscles Fast. Gain Muscle Mass Guide 6Creating An Anabolic State That Supports Muscle ... acids of protein, your muscles cannot grow no matter how hard and oftenyou train your. Protein is the building block of muscles and there are no other nutrients to substituteprotein for muscle ... http://www.buildleanmuscle.com/fast-mass.html and see how you canget a customized muscle building nutrition plan at http://www.mynutritionjournal.com Muscle Audio ProfessorWith the Muscle Audio Professor...
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- atlas of skeletal muscles
- atlas of skeletal muscles 2000
- pathology of skeletal muscle
- the pathophysiology of skeletal muscle ischemia and the reperfusion syndrome
- pericytes in development and pathology of skeletal muscle
- pathophysiology of skeletal muscle
- pathology of skeletal muscle in mitochondrial disorders
- pathology of skeletal muscle carpenter
- pathology of skeletal muscle book
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