... in 30–50% of patients with thymoma or sclerotic myeloma. Table 97-1 ParaneoplasticSyndromes of the Nervous System Syndromes of the brain, brainstem, and cerebellum Focal encephalitis ... Paraneoplastic cerebellar degeneration Opsoclonus-myoclonus Syndromes of the spinal cord Subacute necrotizing myelopathy Motor neuron dysfunction Myelitis Stiff-person syndrome Syndromes ... nerve hyperexcitability Autonomic neuropathy Syndromes of the neuromuscular junction Lambert-Eaton myasthenic syndrome Myasthenia gravis Syndromes of the muscle ...
... Chapter 097. Paraneoplastic Neurologic Syndromes (Part 2) Pathogenesis Most PNDs are mediated by immune responses triggered ... the resistance of many of these conditions to therapy. Table 97-2 Paraneoplastic Antineuronal Antibodies, Associated Syndromes and Cancers Antibody Syndrome Associated Cancers Anti-Hu...
... 096. Paraneoplastic Syndromes: Endocrinologic/Hematologic (Part 1) Harrison's Internal Medicine > Chapter 96. Paraneoplastic Syndromes: Endocrinologic/Hematologic Paraneoplastic Syndromes: ... the prevalence of paraneoplasticsyndromes indicate that they are more common than is generally appreciated. The signs, symptoms, and metabolic alterations associated with paraneoplastic disorders ... in a patient with cancer should prompt consideration of a paraneoplastic syndrome. The most common endocrinologic and hematologic syndromes associated with underlying neoplasia will be discussed...
... Table 96-1 ParaneoplasticSyndromes Caused by Ectopic Hormone Production Paraneoplastic Syndrome Ectopic Hormone Typical Tumor Typesa ... lung, pancreas, ovary aOnly the most common tumor types are listed. For most ectopic hormone syndromes, an extensive list of tumors has been reported to produce one or more hormones. bhCG...
... Unfortunately, many patients will eventually progress despite medical blockade. Chapter 096. Paraneoplastic Syndromes: Endocrinologic/Hematologic (Part 5) Rarely, corticotropin-releasing hormone...
... subtype 2. Octreotide scans may also be useful to detect these tumors. Chapter 096. Paraneoplastic Syndromes: Endocrinologic/Hematologic (Part 6) Tumor-Induced Hypoglycemia Caused by...
... underlying disease rather than a paraneoplastic syndrome. The paraneoplastic hematologic syndromes in patients with solid tumors are less well characterized than the endocrine syndromes because the ectopic ... these tumors (Table 96-2). The extent of the paraneoplasticsyndromes parallels the course of the cancer. Table 96-2 Paraneoplastic Hematologic Syndromes the serum erythropoietin level ... mass. If the red cell mass is elevated, Chapter 096. Paraneoplastic Syndromes: Endocrinologic/Hematologic (Part 7) Hematologic Syndromes: Introduction The elevation of granulocyte, platelet,...
... in 40% of patients with lung and gastrointestinal cancers, 20% of patients Chapter 096. Paraneoplastic Syndromes: Endocrinologic/Hematologic (Part 8) Granulocytosis Approximately 30% of ... 400,000/àL) have an underlying diagnosis of cancer. IL-6, a candidate molecule for the etiology of paraneoplastic thrombocytosis, stimulates the production of platelets in vitro and in vivo. Some ... advanced-stage disease are more likely to have granulocytosis than those with early-stage disease. Paraneoplastic granulocytosis does not require treatment. The granulocytosis resolves when the...