hercus ann 1942— new zealand politician
Tài liệu Báo cáo khoa học: Dual P2Y12 receptor signaling in thrombin-stimulated platelets – involvement of phosphoinositide 3-kinase b but not c isoform in Ca2+ mobilization and procoagulant activity pdf
... with wortmannin or LY294002 It apparently does not implicate modulation of InsP3 receptor Ca2+ channels because InsP3-induced Ca2+ mobilization is not affected by PI3-K inhibition As wortmannin and ... further examined using two structurally distinct inhibitors, wortmannin and LY294002 [21] In the presence of ADP ⁄ P2Y12 activity, wortmannin or LY294002 suppressed the thrombin-induced Ca2+ integral ... maximally effective dose of 200 nm, wortmannin suppressed the thrombin + ADP response by 35 ± 3.4% (Fig 5) Notably, when combined with H89 to block PKA, wortmannin treatment almost completely abolished...
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Tài liệu Báo cáo khoa học: DNA modification with cisplatin affects sequence-specific DNA binding of p53 and p73 proteins in a target site-dependent manner pptx
... p53 preferentially to cisPt-DNA [33,34] Another CTDBS-lacking tetrameric p53 construct, p53CT (spanning amino acids 94–360), has recently been used by Weinberg et al for evaluation of the protein-binding ... PGM1 and PGM4 (not shown) affected the p73 sequence-specific DNA binding basically in the same manner as observed with p53 Possible impacts on gene expression in cisplatin-treated cells It has ... from the research plan No AVOZ50040507 References Vousden KH & Prives C (2005) P53 and prognosis: new insights and further complexity Cell 120, 7–10 El-Deiry WS (2003) The role of p53 in chemosensitivity...
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Tài liệu Báo cáo khoa học: Comparative studies on the functional roles of N- and C-terminal regions of molluskan and vertebrate troponin-I pdf
... regions spanning from the structural TnC-binding sites to the inhibitory regions of Akazara scallop and rabbit TnI, respectively ATnI232)292 and RTnI96)181 correspond to the regions spanning from ... the Mg-ATPase activity of vertebrate actomyosin in a physiologically significant Ca2+dependent manner [21] Moreover, the troponin regulates the ATPase of molluskan myofibril together with a well ... results provide evidence that molluskan troponin functions through a mechanism in which the region spanning from the structural TnC-binding site to the inhibitory region of TnI plays an important role...
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Tài liệu Báo cáo khoa học: The distinct nucleotide binding states of the transporter associated with antigen processing (TAP) are regulated by the nonhomologous C-terminal tails of TAP1 and TAP2 ppt
... diazoxide modulation of ATP-sensitive K (+) channels Circ Res 87, 873–880 Reimann, F., Gribble, F.M & Ashcroft, F.M (2000) Differential response of KATP channels containing SUR2A or SUR2B subunits ... controlling channel activity J Biol Chem 270, 1711–1717 Ó FEBS 2003 Regulation of the nucleotide binding state of TAP (Eur J Biochem 270) 4545 Hrycyna, C.A., Ramachandra, M., Germann, U.A., Cheng, ... 1N2, both with NBD2, bound only to ADP-agarose (Fig 2, top and second panels, left and right) The new TAP chimeric polypeptides 2V1 and 1C2 both bound to ATP- as well as ADP-agarose (Fig 2, left...
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Tài liệu Báo cáo khoa học: The isolation and characterization of cytochrome c nitrite reductase subunits (NrfA and NrfH) from Desulfovibrio desulfuricans ATCC 27774 Re-evaluation of the spectroscopic data and redox properties ppt
... found in remarkable close packing Except for the substrate-binding heme CWXCK, which constitutes a new reaction center, the heme core is fairly conserved when compared to other multiheme cytochromes ... 50 (by mass) Similar amounts of native protein were incubated with a-chymotrypsin (Boehringer Mannheim) for 18 h at 25 °C in 100 mM Tris/HCl, pH 8.6, at an E : S ¼ : 50 Peptides were isolated ... (http://psort.nibb.ac.jp) was used for examination of lipoprotein consensus sequences NrfH sequence was scanned for cytochrome c classes motifs with the program PRINTS33–0 (http:// bioinf.man.ac.uk) Spectroscopy...
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British Government and the Constitution pptx
... 169, 777 Attorney General v News Group Newspapers Ltd [1987] QB 783 Attorney General v Newspaper Publishing plc [1988] Ch 333 .369, 777 Attorney General v Times Newspapers Ltd [1974] AC 273 ... Attorney General v Guardian Newspapers Ltd [1987] WLR 1248 271, 777–8, 780 Attorney General v Guardian Newspapers Ltd [1992] WLR 874 784 Attorney General v Guardian Newspapers Ltd (No 2) [1990] ... 229 269 T, Petitioner 1997 SLT 724 271 Tamlin v Hannaford [1950] KB 18 354 xl Table of Cases Taylor v New Zealand Poultry Board [1984] NZLR 394 67 Tesco Stores Ltd...
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Báo cáo khoa học: The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B1 and B2 bradykinin receptors potx
... mechanism and role in inflammatory disorders Annu Rev Immunol 6, 49–83 14 Farmer SG & Burch RM (1992) Biochemical and molecular pharmacology of kinin receptors Annu Rev Pharmacol Toxicol 32, 511–536 ... to the normally noninternalizing B1wt, via transfer of the C-terminus of B2wt, provided that the new chimeric receptors have an intact ⁄ homogeneous helix either from B2wt or B1wt or a chimeric ... ⁄ streptomycin were purchased from PAA Laboratories (Colbe, Germany) Fugene was from Roche ¨ (Mannheim, Germany) and Invitrogen supplied hygromycin B and blasticidin Poly(lysine), captopril,...
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C++ Lab 10 Structures (Struct) and Files pot
... invoked using the dot notation, example: outfile.open (“myfile.txt”) or outfile.close() Stream: Channel or circuit on which data are passed from sender to receiver one character at a time If receiving...
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Victor McLaglen, the British Empire, and the Hollywood Raj: Myth, Film, and Reality pot
... cricket clubs and Sunday afternoon tea parties, employing nannies and butlers, and displaying a highly developed sense of superiority toward the manners and customs of their American cousins The centre ... studio spent weeks trying to foist better-known heavies on me, said Ford, but I knew Vic could the job, and I knew I could handle him exactly as I wanted to I won in the end—and you saw the performance ... ing dead, awaits new cinematic historical interpretations VICTOR MCLAGLEN 59 Notes Richard A Voeltz, “Victor McLaglen and the British Empire: Myth, Film, and Reality” at the annual meeting of...
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Báo cáo khoa học: Selective modulation of protein C affinity for EPCR and phospholipids by Gla domain mutation pdf
... Rand MD & Mann KG (1994) The mechanism of inactivation of human factor V and human factor Va by activated protein C J Biol Chem 269, 31869–31880 11 Kalafatis M, Bertina RM, Rand MD & Mann KG (1995) ... plasma protein C associated with RCR-2 immobilized wild-type sEPCR in a concentrationdependent manner (Fig 3A) The association and dissociation rate constants were 12.1 ± 1.29 · 105 m)1Æs)1 and ... binding to recombinant sEPCR, and by their abilities to inactivate FVa in a phospholipiddependent manner Two of the variants (R-1L and R-1C) were purified from the plasma of heterozygous carriers...
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C#1 introduction to programming and the c language potx
... C# Finally I am closing the book with part as two slightly larger examples Part illustrates not new substances, and in order to continue reading the other books you can very well skip this part ... errors, you get an error message and the error must be corrected before the program is translated anew Not all errors are found during compilation, but only syntax errors that are errors where a ... requirements for the architecture of a C# program Exam01 Hello World A good place to start with a new programming language is the classic Hello World program that just prints a text on the screen...
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Nicolai josutis the c++ standard library a tutorial and reference
... //initialize an auto_ptr with a new object std::auto_ptr ptr1 (new ClassA); //initialize another auto_ptr with a new object std::auto_ptr ptr2 (new ClassA); ptr2 = ptr1; //assign ... resource leak if second new throws ClassB (ClassA val1, ClassA val2) : ptr1 (new ClassA(val1)), ptr2 (new ClassA(val2)) { } //copy constructor //- might cause resource leak if second new throws ClassB ... ClassA val2) : ptr1 (new ClassA(val1)), ptr2 (new ClassA(val2)) { } //copy constructor //- no resource leak possible ClassB (const ClassB& x) : ptr1 (new ClassA(*x.ptr1), ptr2 (new ClassA(*x.ptr2))...
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Object oriented programming with C++ - Session 3 Function Overloading and References ppt
... can continue to use the old number of arguments, while new function calls can use more Object Oriented Friend Functions Private data values cannot be read or written to by non-member functions We ... xyz); }; void display(Student abc, Teacher xyz) {//… some code…} Forward declaration: A class cannot be referred to until it has been declared Therefore, class Teacher has been declared before ... to some extent A friend function has to be declared in the class whose data it will access This cannot be done if the source code is not available to a programmer If the source code is available,...
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Object oriented programming with C++ - Session 6 Multiple Inheritance and Polymorphism pot
... objects as well as to simple data types Base* ptr; ptr = new Base; s To refer to member functions in the object pointed to by ptr we cannot use a dot operator • The dot operator requires the ... 44 Example class Alpha{ private: char* alpha_ptr; public: Alpha() //constructor cannot be virtual {alpha_ptr = new char[5];} virtual void fn(); //virtual member function virtual ~Alpha() //virtual ... Alpha{ private: char* ptrderived; public: Beta() {ptrderived = new char[100];} ~Beta() {delete[] ptrderived;} }; void main() { Alpha *ptr = new Beta; delete ptr; } Object Oriented Programming with...
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Báo cáo khoa học: Characterization of testis-specific serine–threonine kinase 3 and its activation by phosphoinositide-dependent kinase-1-dependent signalling doc
... Katschinski DM, Marti HH, Wagner KF, Shibata J, Eckhardt K, Martin F, Depping R, Paasch U, Gassmann M, Ledermann B et al (2003) Targeted disruption of the mouse PAS domain serine ⁄ threonine kinase ... TSSK3) for Tyr to create the sequence more resembling the best-phosphorylated peptide We tested all newly created peptides for their ability to be phosphorylated by TSSK3 (Fig 5C) We observed that ... Cys Oligonucleotides contained EcoRI overhang on 5¢ site and NotI overhang on 3¢ site to ligate annealed oligonucleotides into pGEX)6P-1 vector cut with EcoRI, NotI Additionally, oligonucleotides...
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Báo cáo khoa học: N-terminal deletion of the c subunit affects the stabilization and activity of chloroplast ATP synthase doc
... Sephadex G-50 was purchased from Pharmacia (Uppsala, Sweden) DEAE-cellulose was obtained from Whatmann (Uppsala, Sweden) and hydroxyapatite from Bio-Rad (Hercules, CA, USA) Other reagents were all ... 545, 61–70 McCarty RE, Evron Y & Johnson EA (2000) The chloroplast ATP synthase: a rotary enzyme? Annu Rev Plant Physiol Plant Mol Biol 51, 83–109 Richter ML, Hein R & Huchzermeyer B (2000) Important ... (1999) The c subunit in chloroplast F1-ATPase can rotate in a unidirectional and counter-clockwise manner FEBS Lett 463, 35–38 Matsui T & Yoshida M (1995) Expression of the wildtype and the Cys- ⁄...
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Scientific Database Management (Panel Reports and Supporting Material) ppt
... One cannot expect that any new system should or could be adopted by all Private databases will still be necessary for efficiency in processing, for convenience, or for historical reasons New SDB ... required in scientific applications The systems should facilitate the addition of new data types, new data structures, and new manipulation operators It should be possible to describe these additions ... model), to satisfy all new applications In contrast, the goal of the DBMS toolkit projects is to provide tools that will enable new DBMSs to be easily constructed to handle new and different applications...
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Báo cáo khoa học: Disease-related mutations in cytochrome c oxidase studied in yeast and bacterial models pptx
... properties [8] These changes are likely due to altered K-channel function as both M273 and I280 are closely associated with two key residues of the K-channel, K319 and T316 [17,18] The sulfur and carbonyl ... J.T & DiMauro, S (1995) A new mutation asso- 33 34 35 36 37 38 ciated with MELAS is located in a mitochondrial DNA polypeptide-coding gene Neuromusc Disord 5, 391–398 Hanna, M.G., Nelson, I.P., ... Consistent with this, G317S had no effect in yeast [8] Two other mutations in the region of the K-channel, I280T and M273T have been observed in hematopoietic cells of patients suffering from acquired...
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speak the culture britain be fluent in british life and culture
... and sacrifice Key dates Ruling the waves By the mid 18th century Britannia was ruling the waves (James Thomson’s poem Rule Britannia! was set to music by Thomas Arne in 1740 and was an overnight ... congregation of more than 400 million souls by the early 20th century India, Burma, Australia, New Zealand, Canada, the Caribbean, a line of dependencies running through Africa from Egypt down ... Belgium on its way to France in 1914, Britain honoured its new Entente Cordiale with the old enemy and declared war on the Germans Britain’s new working class signed up to fight in their millions,...
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