david s goodsell hemagglutinin rcsb protein data bank april 2006 http www rcsb org pdb static do p education discussion molecule of the month pdb76 1 html accessed july 16 2009
Tài liệu Protein Data Bank Contents Guide: Atomic Coordinate Entry Format Description Version 3.20 Document Published by the wwPDB ppt
... which the molecule was expressed EXPRESSION_SYSTEM_VARIANT Variant of the organism used as the expression system EXPRESSION_SYSTEM_CELL_LINE The specific line of cells used as the expression system ... system EXPRESSION_SYSTEM_ATCC_NUMBER Identifies the ATCC number of the expression System EXPRESSION_SYSTEM_ORGAN Specific organ which expressed the molecule EXPRESSION_SYSTEM_TISSUE Specific tissue ... name of the organism in which the molecule was expressed EXPRESSION_SYSTEM_TAXID NCBI Taxonomy ID of the organism used as the expression system EXPRESSION_SYSTEM_STRAIN Strain of the organism in...
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Tài liệu The Protein Data Bank: a historical perspective ppt
... diversity of structures in the PDB archive These images, shown to scale, were created by David S Goodsell (The Scripps Research Institute), who also writes and illustrates the RCSB PDB s Molecule ... sites offer numerous services including simple and complex searches as well as a variety of visualization methods In addition, the RCSB PDB (http: / /www. pdb .org) provides browsing capabilities ... weekday, two pages from the site are viewed every second Data are accessed via the website, ftp servers (supporting ftp and rsync access), web services and RSS feeds Until the 19 90 s, interactive...
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THE PROTEIN DATA BANK pptx
... Status Query (http: / /www .rcsb. org/ pdb/ status .html ), SearchLite (http: / /www .rcsb. org/ pdb/ searchlite .html ) and SearchFields (http: / /www. rscb .org/ pdb/ queryForm.cgi ) Table summarizes the current ... deposited at this site will be processed by the PDB staff In time, the staff at Osaka will complete the data processing for these entries and send the files to the PDB for release NMR data The ... been processed and are being released after author review The breakdown of the types of structures in the PDB is shown in Table As of September 14 , 19 99, the PDB contained 10 714 publicly accessible...
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Published quarterly by the Research Collaboratory for Structural Bioinformatics Protein Data Bank ppt
... molecular graphics system, http: / /www. pymol .org/ RCSB Protein Data Bank Newsletter RCSB PDB Partners The RCSB PDB is managed by two partner sites of the Research Collaboratory for Structural Bioinformatics: ... methods During the same time period, 2027 structures were released in the PDB wwPDB News Changes to the wwPDB Policy for Depositing Polypeptide Structures The wwPDB now accepts polypeptide structure ... experimentally-determined structures were deposited to the PDB archive The entries were processed and annotated by wwPDB teams at the RCSB PDB, PDBe, and PDBj Searching for ligands using the RCSB PDB 's Advanced Search,...
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bionanotechnology lessons from nature - david s. goodsell
... that stabilize transition states Enzymes use chemical tools to perform a reaction 10 3 10 5 11 3 11 5 11 6 11 7 11 8 11 9 12 1 12 2 12 7 12 9 13 0 13 4 13 5 13 6 13 6 14 0 14 2 14 5 14 6 14 9 15 1 15 5 15 6 15 8 16 2 16 3 16 4 ... Natural proteins may be simplified Proteins are being designed from scratch Proteins may be constructed with nonnatural amino acids 16 7 16 7 17 1 17 3 17 4 17 7 18 1 18 4 18 7 18 9 19 0 19 4 2 01 203 205 ... channels use a selectivity filter ABC transporters use a flip-flop mechanism Bacteriorhodopsin uses light to pump protons Biomolecular Sensing Smell and taste detect specific molecules Light is sensed...
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Báo cáo y học: "Segregation of a M404V mutation of the p62/sequestosome 1 (p62/SQSTM1) gene with polyostotic Paget''''s disease of bone in an Italian family" pps
... not be assessed in patient III-6, these hypotheses strongly support the need for further investigation into the possible role of the p6 2 protein in the occurrence of osteosarcoma, both in PDB- affected ... explanation of the observed genotype–phenotype correlation in the Italian family with PDB described in this paper Discussion Several lines of evidence [2-7] support the role of the p6 2/ SQSTM1 ... Analysis of the forward and reverse sequences was performed on an ABI Prism 310 0 Genetic Analyzer (Applied Biosystems, Foster City, CA, USA) Results Clinical data Suspicion or diagnosis of PDB was...
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Báo cáo y học: "BioAfrica''''s HIV-1 Proteomics Resource: Combining protein data with bioinformatics tools" potx
... variability of the integrase protein from a diverse collection of HIV type isolates representing several subtypes AIDS Res Hum Retroviruses 2002, 18 :10 31- 10 41 Bairoch A, Apweiler R: The SWISS-PROT protein ... history of protease cleavage sites, and on the natural selection pressures exerted on these sites The section also serves as a baseline for understanding the impact of natural polymorphisms and ... multiply spliced mRNA (p1 4); the other from singly-spliced mRNA (p1 6) [7] Important functional domains include the acidic, amphipathic region (1MEPVDPRLEPWKHPGSQPKTA- 21; the hydrophobic residues...
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Báo cáo khoa học: Functional fine-mapping and molecular modeling of a conserved loop epitope of the measles virus hemagglutinin protein pdf
... experiments with peptide-conjugates Materials and methods Synthetic peptides Peptides were prepared by automated solid-phase peptide synthesis using standard Fmoc chemistry on a SYRO peptide synthesizer ... 0 .12 1. 5 >10 0.08 0.08 0 .10 0 .10 0 .12 0 .12 0 .18 0.20 0.60 0.60 0.60 0.60 0.80b 1. 5 >10 >10 >10 >10 Yes Yes No Yes Yes No Yes Yes Yes Yes No No Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes ... determined Preparation of sensor surfaces Reporter HNE peptide was coupled to the sensor surface as described by the supplier (BIAapplications Handbook, Biacore, Uppsala, Sweden) Briefly, a 10 0 lM solution...
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Bad Bank(s) and Recapitalization of the Banking Sector docx
... If the bank has not enough cash earnings it can compensate the SPV by shares At closure date the bank receives cash as the SPV pays off the government bond If the SPV would produce a loss in the ... of burdens” Source: DIW Berlin 2009 Appendix 1: Example of how the proposed bad bank design works The following simple example illustrates how the proposed design of a bad bank plan works Costs ... date of toxic assets Assets Liabilities Toxic Assets Debt Total Assets Assets Selling price of Toxic Assets Total Assets Total Liabilities Table 1e: Bad bank 's final balance sheet Liabilities 50...
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Department of Health and Human Services: 45 CFR Parts 60 and 61 National Practitioner Data Bank; Proposed Rule pdf
... 11 1 01 et seq.) The HCQIA authorizes the NPDB to collect reports of adverse licensure actions against physicians and dentists (including revocations, suspensions, reprimands, censures, probations, ... reported to the NPDB under section 19 21 Subsection (b) also adds new provisions under section 19 21 that are modeled on similar provisions in section 11 28E These new provisions require the Secretary ... suspension, reprimand, probation, surrender, censure ■Adverse clinical privileges actions (primarily physicians/dentists) ■Adverse professional society membership (primarily physicians/dentists)...
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To Cut or Not to Cut? That is the (Central Bank’s) Question In Search of the Neutral Interest Rate in Latin America pdf
... the banking system See also Citibank (2 011 ) 24 The analysis on MaPP seems to be symmetric, except for its fiscal cost If capital inflows are sterilized (purchasing reserves with domestic paper) ... different currencies 23 Evidence on these issues is still to be presented But a deeper discussion of the role of MaPPs as complement or substitute to standard interest rate polices deserves better attention ... Mexico 13 11 1 -1 -1 2005 2006 2007 2008 2009 2 010 2 011 2 012 Peru -3 2000 10 2002 2004 2006 2008 2 010 2 012 Uruguay -5 -10 -1 2007 2008 2009 2 010 2 011 2 012 10 Dominican Republic 13 11 -1 -3 -5...
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Báo cáo khoa học: In vitro gamma-secretase cleavage of the Alzheimer’s amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc potx
... mass fractions of the 0.5% CHAPSO separations when compared to the recovery of these proteins predominantly in high molecular mass fractions during 0.25% CHAPSO separation Collectively these data ... detected Thus, substrate limitation is not the reason that PS1 complexes of this size range were unable to sustain robust c-secretase activity Original reports on the size of PS1 and c-secretase activity ... inhibitor of csecretase cleavage of APP Results Design of a novel APP c-secretase substrate and standards Sensitive western blot assays for c-secretase were based on the production of a 3FLAG-tagged...
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Báo cáo khoa học: Role of CCP2 of the C4b-binding protein b-chain in protein S binding evaluated by mutagenesis and monoclonal antibodies docx
... one of the F 114 A/I 116 A forms binds protein S The results suggest that the correctly folded F 114 A/I 116 A variant binds protein S at least equally as well as the wild-type variant The apparent slightly ... 50% of 12 5-I protein S binding SD Wild-type H108A F 114 A/I 116 A 8 .1 7.9 7.8 ± 0.2 ± 0 .1 ± 0.2 Fig Western blot analysis of plasma purified C4BP using MoAb 44 Three micrograms of plasma purified C4BP ... b-chain This suggests that the epitope for MoAb 44, possibly involving both CCP1 and CCP2, is closer to the protein S binding site than the epitope for MoAb 15 These results point in the direction...
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Báo cáo Y học: S-Decyl-glutathione nonspecifically stimulates the ATPase activity of the nucleotide-binding domains of the human multidrug resistance-associated protein, MRP1 (ABCC1) ppt
... nmol PiÆmg )1 min )1 [14 ] The MBP-fused versions of NBD1 and NBD2 have similar ATPase activities as the GST-fused proteins In contrast, the ATPase activity of the nonfused NBD1 (without GST- or MBP-moiety) ... and the drug-stimulated ATPase activity of MRP1 [ 51] and P- gp [52], similar to the effects on the ATPase activity of ABCR [53] This is supported by the close proximity of the NBDs of P- gp to the ... measured in absence of surfactant The absolute ATPase activities of the proteins in these experiments were, depending on protein preparation, in the range of 0.3–0.5 (pmol Pi)Æ(pmol protein) )1 min)1...
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Báo cáo khoa học: Human delta-lactoferrin is a transcription factor that enhances Skp1 (S-phase kinase-associated protein) gene expression pdf
... Electrophoretic mobility shift assay of Lf with S 1Skp1 and S 2Skp1 elements S 1Skp1 and S 2Skp1 correspond to 30-mer oligonucleotides containing one repeat of S1 Skp1 or S2 Skp1 placed in the center ... both the S1 Skp1 and S2 Skp1 sequences was cloned into the pGL3 promoter luciferase reporter vector Next, a 13 2 bp product, which contains only the S1 Skp1 sequence () 11 64 bp to ) 10 33 bp), and a 13 8 ... pGL3 -S1 Skp1; pGL 3S2 Skp1; pGL3-534-DS1Skp1, and pGL3-534-DS2Skp1) (250 ng per well) and pcDNA-DLf in the range 250 10 00 ng per well The functionality of the DLf consensus NLS bipartite sequence was...
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Báo cáo khoa học: Inhibition of the D-alanine:D-alanyl carrier protein ligase from Bacillus subtilis increases the bacterium’s susceptibility to antibiotics that target the cell wall potx
... reactions are 3.23 · 10 5 m )1 s) 1 and 9.94 · 10 4 m )1 s) 1 for AcpS and Sfp, respectively Thus, although the Km of Sfp is almost six times as A 16 0 14 0 12 0 10 0 V [1/ min] restriction on the synthesis of ... kinetics of the modification with both PPTases (AcpS, the PPTase of primary metabolism and Sfp, the PPTase of secondary metabolism) were measured For this purpose, an HPLC assay was carried out The ... inhibition of the Dlt system J J May et al Fig D-Ala-biosynthesis gene clusters from B subtilis and their corresponding domain organization of NRPS-like proteins (A) Genes are depicted as arrows, proteins...
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báo cáo khoa học: " Acute thrombosis of the superior mesenteric artery in a 39-year-old woman with protein-S deficiency: a case report" pot
... is prompt diagnosis in patients with AMI Numerous surgical reports indicated that acute intestinal ischemia (AII) is associated with a poor prognosis [13 ] The poor signs, symptoms, and nonspecific ... Journal of Medical Case Reports 2 011 , 5 :17 http: / /www. jmedicalcasereports.com/content/5 /1/ 17 cannot aid in the diagnostic process because they are nonspecific (inorganic phosphate, lactic acid, aldolase, ... early planned repeated laparotomy improves the prognosis of the surgical approach Although the prognosis of the AMI due to an acute arterial mesenteric thrombosis remains poor, a prompt diagnosis,...
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Báo cáo y học: "Antinuclear antibodies in healthy people: the tip of autoimmunity’s iceberg? David S Pisetsky1,2" pot
... Pisetsky Arthritis Research & Therapy 2 011 , 13 :10 9 http: //arthritis-research.com/content /13 /2 /10 9 such as lupus and rheumatoid arthritis as well as defense against malaria [7] ... more extensive analysis of the serology of various racial and ethnic groups would be informative, as would the study of populations in other locales [8] As shown in this and other studies, ANA reactivity ... polymorphisms and systemic lupus erythematosus in African-americans J Rheumatol 2003, 30:60-67 Borchers AT, Naguwa SM, Shoenfeld Y, Gershwin ME: The geoepidemiology of systemic lupus erythematosus Autoimmunity...
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THE INFLUENCE OF THE KU80 CARBOXY-TERMINUS ON ACTIVATION OF THE DNA-DEPENDENT PROTEIN KINASE AND DNA REPAIR IS DEPENDENT ON THE STRUCTURE OF DNA COFACTORS Derek S.
... and Serine are phosphorylated by DNA-PKcs The phosphorylation of these serines significantly stimulates the phosphorylation of Ser12 by 21 ATM and DNA-PKcs while moderately stimulating the phosphorylation ... because they prevent the separation of DNA strands which is essential for cellular processes such as replication and transcription To resolve such lesions the interstand crosslink repair pathway produces ... analysis was completed using Sigma Plot 11 .0 software using a Student s t- test The P
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WHAT’S NEXT ; Unconventional Wisdomon the Future of the World Economy Edited by David Hale and Lyric Hughes Hale
... perspective, by significantly raising costs or imposing other constraints Of particular concern to Canada was the passage in the US House of Representatives of the American Clean Energy and Security ... unprecedented levels Bankers cut credit lines Consumers reacted to these shocks by slashing their spending, especially in up-market retailers Corporations sharply curtailed capital spending As the credit ... objectives and a principles-based approach to regulation as opposed to a rules-based approach (as in the United States) This, in turn, has contributed to a more conservative risk appetite by banks As...
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