change in biochemical markers of bone turnover and radiographic outcome after treatment
Báo cáo y học: "Biochemical markers of bone turnover and their association with bone marrow lesions" docx
... with increased levels of bone resorption markers reported in patients with radiographic evidence of knee OA, including type I collagen [17] and deoxypryidinoline [18] In addition to bone being ... analyses Bone biomarkers Biochemical markers of bone turnover were assayed in archived serum and urine stored at -70°C We measured two serum bone formation markers: osteocalcin and bone- specific ... such as that showing the urinary excretion of pyridinium cross-links is significantly increased in patients with large joint OA and hand OA, suggesting an increased rate of bone turnover [34] Recently,...
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Báo cáo y học: "A prospective assessment of the inter-laboratory variability of biochemical markers of fibrosis (FibroTest) and activity (ActiTest) in patients with chronic liver disease" ppt
... procedure [2] Reviews of morbidity and mortality of intercostal liver biopsy observed a mean occurrence of pain in 30 % of patients, out of 1,000 endured severe adverse events, and out of 10,000 died ... inappropriate [8– 10], a major concern was the definition of ALT and GGT activity In routine practice, the definition of the upper limit of normal (ULN) of ALT and GGT varies between laboratories, but ... used and expression of alanine aminotransferase and γglutamyl transpeptidase in multiples of the upper limit of reference values should not be employed Background The "gold standard" for assessing...
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Báo cáo y học: " Imbalance of local bone metabolism in inflammatory arthritis and its reversal upon tumor necrosis factor blockade: direct analysis of bone turnover in murine arthritis" ppsx
... Chronic inflammation can lead to sustained alterations of bone turnover, as typically seen in juxta-articular and periarticular damage of inflamed joints in RA TNF is a proinflammatory cytokine of ... effects on bone make TNF an ideal candidate for linking inflammation and bone loss Indeed, the therapeutic blockade of TNF is highly effective in preventing and/ or reducing skeletal damage in conditions ... of TNF overexpression, these analyses revealed several interesting insights into arthritic bone loss, as illustrated in Figure First, bone turnover was massively increased at sites of joint inflammation...
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Báo cáo y học: "Overview of the diagnostic value of biochemical markers of liver fibrosis (FibroTest, HCV FibroSure) and necrosis (ActiTest) in patients with chronic hepatitis C" doc
... combinations of stages and grades, including combinations with blood donors This allowed, for example, a comparison to be made of the diagnostic value of FT for discriminating between F1 and F2 after ... line assessment of liver injury in patients with chronic hepatitis C In clinical practice, liver biopsy should be recommended only as a second line test, i.e., in case of high risk of error of ... DT, VR, and YB participated in the coordination of the study, and drafted the manuscript AM participated in the design and coordination of assays in the control group All authors read and approved...
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Báo cáo khoa học: Change in structure of the N-terminal region of transthyretin produces change in affinity of transthyretin to T4 and T3 pdf
... PAGE, indicating that the recombinant TTRs as tetramers Analysis of binding to retinol-binding protein and thyroid hormones showed that the recombinant TTRs retained its function as binding protein ... determine the in uence of the N-terminal region of TTR on the binding to thyroid hormones, the construction of chimeric recombinant TTRs containing variations in structure of the N-terminal region ... thereafter linearized with Sal I and introduced into P pastoris Screening of transformants and induction of synthesis of recombinant proteins were preformed as described for the recombinant human...
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báo cáo hóa học:" Risk factor analysis for early femoral failure in metal-on-metal hip resurfacing arthroplasty: the effect of bone density and body mass index" potx
... a body mass index ≥35kg/m2 increases the complexity of exposing the hip and accurately placing the 13 component, therefore increasing the risk in femoral notching [3, 14] Our study indicated that ... already surpassed the learning curve of hip resurfacing procedures prior to this study Beginning in July 2006, we routinely recorded bone mineral density with the use of a dual energy x-ray absorptiometry ... the outcome of Birmingham hip resurfacing J Bone Joint Surg Am 2010, 92:105-112 10 Ball ST, Le Duff MJ, Amstutz HC: Early results of conversion of a failed femoral component in hip resurfacing...
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Báo cáo y học: "Single amino acid change in gp41 region of HIV-1 alters bystander apoptosis and CD4 decline in humanized mice" potx
... apoptosis in the presence of significant infection and replication in SupT1 cell line Interestingly bystander apoptosis is seen quiet early in WT infected cultures, suggesting that in fact, a few infected ... apoptosis induction in vitro [28,46-49] Our in vitro data in this study using WT or V38E infected Sup-T1 cells confirms this hypothesis We find that V38E mutant is incapable of inducing bystander ... difference was also maintained at the weeks end point of our study when we looked at the CD4 levels in the spleen (Figure 2B) In a repeat of the study in a larger set of mice consisting of mice per group...
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Báo cáo y học: " Reconstitution of the myeloid and lymphoid compartments after the transplantation of autologous and genetically modified CD34+ bone marrow cells, following gamma irradiation in cynomolgus macaques" potx
... resulting in the formation of clusters of GFP-positive cells within a single myeloid colony In our in vivo study, autologous HSC were injected into the bone marrow, whereas intravenous injection ... results obtained in vitro and in vivo in an experiment assessing the efficacy and safety of a gene transfer protocol based on the transduction of simian CD34+ bone marrow cells with a minimal SIVmac251derived ... baboon marrow repopulating cells using recombinant human fibronectin fragment CH-296 in combination with interleukin-6, stem cell factor, FLT-3 ligand, and megakaryocyte growth and development factor...
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Báo cáo y học: " Intra-individual fasting versus postprandial variation of biochemical markers of liver fibrosis (FibroTest) and activity (ActiTest)" pdf
... bilirubin, triglycerides, total protein, and albumin An interesting finding for α2 macroglobulin and haptoglobin, two main non-albumin proteins included in FT-AT, was that the variation of total ... in an apparently healthy volunteer with a small increase of fasting ALT (75 IU/l) and an increase in postprandial ALT (115 IU/l) Fasting and postprandial FT's were normal The total calories of ... only abnormal findings were a small increase in body mass index (26.8 kg/m2), long-term medication use of the contraceptive pill and the ingestion of a NSAID (ibuprofen) for pelvic pain 48 hours...
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Báo cáo y học: "Markers of collagen synthesis and degradation are increased in serum in severe sepsis: a longitudinal study of 44 patients" pdf
... maximum PINP and PIIINP and maximum lactate level (P < 0.001 for both PINP and PIIINP) and PINP and PIIINP and liver and kidney-specific SOFA scores ROC curve analysis of maximum PIIINP for liver ... levels of PIIINP and ICTP are significantly increased in patients with severe sepsis and can be investigated further as markers of disease severity and outcome • PIIINP and ICTP values in survivors ... location of infection in the surgical group was intra-abdominal (15 of 25) In the medical group, infections in the lungs were most abundant (13 of 19) The blood culture was positive in 13 cases and...
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Báo cáo y học: "Endogenous plasma activated protein C levels and the effect of enoxaparin and drotrecogin alfa (activated) on markers of coagulation activation and fibrinolysis in pulmonary embolism." ppt
... no signs of a systemic profibrinolytic effect of enoxaparin, or the combination of enoxaparin with DAA The lack of a profibrinolytic effect of enoxaparin or DAA combined with enoxaparin was also ... degradation products decrease in parallel Addition of DAA to enoxaparin in the initial treatment phase resulted in a more rapid decline in soluble fibrin, D-dimer, and fibrinogen/fibrin degradation products, ... fibrin formation and fibrin dissolution Anticoagulant therapy with enoxaparin blunted intravascular fibrin formation, leading to a decline in soluble fibrin levels D-dimer and fibrinogen/fibrin...
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Báo cáo y học: "Advances in Molecular Diagnosis of HBV Infection and Drug Resistance"
... to lamivudine emerges in approximately one quarter of patients after one year of treatment [1113], rising to more than 40% after two years, and increasing further to over 50% and 70% after years ... two include the substitution of methionine (M) by the amino acids isoleucine (I) or valine (V) in the YMDD motif (C domain) at position rtM204V/I In the majority of cases, these mutations in the ... resistance, and can generally be divided into genotypic assays and phenotypic methods The former detect changes in the HBV genomic sequence in the course of treatment In addition, indirect measures of...
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Tài liệu Báo cáo khoa học: The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase) pptx
... protein is not assembled into the human complex I Inspection of the amino acid sequences of the known mammalian ESSS proteins reveals a high degree of conservation in the C-terminal domain (including ... protein–protein interactions with other hydrophilic domains of neighboring integral membrane subunits, and interspecies interactions are incompatible From the comparative studies with a series of Chinese ... to form a domain on the matrix side, and 36 form a domain extending into the intermembrane space In the third mutant (V79-G35) one might expect a protein to be inserted into the inner membrane,...
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Báo cáo khoa học: Insertion of the plant photosystem I subunit G into the thylakoid membrane In vitro and in vivo studies of wild-type and tagged versions of the protein doc
... concentration of mgÆmL)1 and boiling loading buffer In the case of thylakoids, the samples were washed in 400 lL HM and the pellets resuspended in trypsin inhibitor and boiling loading buffer Samples ... disrupting protein–protein interactions within PSI, or by altering the conformation of the loop His-tags were employed in a topological study of the major light harvesting chlorophyll a ⁄ b binding ... harvesting complex (LHCI), consisting of four members (Lhca1–4) of the chlorophyll a ⁄ b binding protein family LHCI is bound along one side of PSI only, in the vicinity of the PSI-F and PSI-J...
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Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf
... sufficient for inducing activation of GS in muscle and fat cells, and that inhibition of the kinase potentiates insulin action in muscle of insulin-resistant rats [39], and that prolonged GSK3 inhibition ... enhanced in insulin-resistant muscle and the kinase has been implicated in down-regulating insulin signalling via its ability to serine phosphorylate IRS1 [40], it is possible that inhibition of GSK3 ... submaximal insulin dose (Fig 5) These findings are not entirely out of line with work from rodent studies showing that whilst GSK3 inhibition improves insulin responsiveness in muscle of insulin resistant...
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Hevea in New Area of Thailand: Success and Growth potx
... Background of Rubber Plantation in Non-traditional area Since year 1989; Thai government policy has expanded rubber plantation to non-traditional area Background of Rubber Plantation in 2004; expanded ... mil.ha Recent rubber planting areas (in 2004) more constraint both land and environment than rubber plantations in the past such as low soil fertility unsuitable soil physic rainfall average only 1,000-1,200 ... plantations in the Northeast region : 19 provinces : 1,500 holdings Methodology appointment with farmers interview to know basic data of each farm; location, management, workers etc collected data in...
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Philosophy in a New Key A Study in the Symbolism of Reason, Rite, and Art
... growth, beginning with the early Church Fathers and culminating in the great Scholastics But, at last, its generative ideas—sin and salvation, nature and grace, unity, infinity, and kingdom—had ... acculturated, including among other patterns ways of using available instruments for reaching and climbing, a sort of rhythmic play or dance, and types of murmurs, wails and rejoicings "It is ... valuable insight The acquisition of so decisive a tool must certainly be regarded as one of the great landmarks in human progress, probably the starting point of all genuinely intellectual growth Since...
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Báo cáo khoa học: Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis pptx
... in our knowledge of the biosynthesis of DIMs and PGLs, the in vivo functions of these FadD proteins in this pathway remain to be established and ⁄ or completed For instance, the involvement of ... controlled in vivo by specific interactions between FadD29 and PKS15 ⁄ on the one hand, and FadD26 and the FasI system on the other hand Further investigations, including protein interaction studies and ... mutation of fadD26 and the absence of DIMs in PMM137, complementation studies were performed by transferring a plasmid, named pM26D, containing a wild-type copy of fadD26, into the mutant strain Complementation...
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Water Pollution Control in China: Review of laws, regulations and policies and their implementation pptx
... Administration; MF=Ministry of Forestry Notes: NDRC=National Development and Reform Commission; MOF=Ministry of Finance; MWR=Ministry of Water Resource; MOC=Ministry of Construction; MOA=Ministry ... of shutting down, merging and transferring Enforcement of shutting down, merging and transferring system is stipulated as “enterprises that of low profit, high environmental pollution level and ... feature of economic growth in Taihu River Basin is the rapid growth of TVEs Most of TVEs are of chemical industry, paper-making industry, electroplating industry and other heavy pollution industries...
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Báo cáo khoa học: A study of microRNAs in silico and in vivo: bioimaging of microRNA biogenesis and regulation doc
... understanding of the production and function of miRNA in vivo as well as for monitoring the therapeutic potential of miRNAs in cancer Bioimaging of microRNA biogenesis The molecular mechanisms involved ... networks during developmental stages and the changes of these networks in disease and after application of a variety of therapeutic strategies Critically, 2172 the noninvasive imaging approach of miRNA ... vivo investigations of miRNA production patterns Second, noninvasive monitoring of miRNAs provides useful information of the possible role of miRNAs involving cellular developments Third, the in...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng 9 tr 25