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Báo cáo y học: "Spontaneous Hemoperitoneum Caused By a Diverticulum of the Sigmoid Colon"
... identifying patients at risk for complicated diverticular disease. Dis Colon Rectum. 1991;34:339-42. 4. Kourtesis GJ, Williams RA, Wilson SE. Surgical options in acute diverticulitis: value of sigmoid ... Schumpelick V. Increased distribution of collagen type III and reduced expression of matrix metalloproteinase 1 in patients with diverticular disease. Int J Colorectal Dis. 2001;16:271-5. 3. ... (arrow). Discussion The prevalence of diverticulum in patients aged 65 years or more is as high as 65%, but merely 5% in those below 40 years of age [6]. Sigmoid colon diverticulum is closely...
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KRONE - What is Patch by Exception
... even easier.HOW TO GET THE MOST OUT OF PATCH BY EXCEPTIONMany organisations have successfully implemented the Patch by Exception solution by establishing a maintenance contract with an installer ... manage, but that will accommodate the developing technologies of tomorrow.WHAT IS PATCH BY EXCEPTION?Patch by Exception is a product feature of KRONE's HIGHBAND 8 and 10 modules that allows ... changes without the need for assistance from an installer.To date this has been achieved by assigning a hub port and an extension port to each individual within an organisation. If an individual...
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Tài liệu Báo cáo khoa học: TMPRSS13, a type II transmembrane serine protease, is inhibited by hepatocyte growth factor activator inhibitor type 1 and activates pro-hepatocyte growth factor pdf
... the tissuesproducing it. In response to tissue injury, such ashepatic and renal injury, the inactive single-chain HGF is converted to a two-chain form exclusively inthe injured tissue. This ... exclusively inthe injured tissue. This conversion is mediated by ser-ine protease activity, which is induced in the injuredtissue [28]. The two-chain form is required for the bio-logical activity ... TMPRSS13.Proteolytic activation of pro-HGF by TMPRSS13Pro-HGF is proteolytically activated by matriptaseand hepsin, and the protease activity is inhibited by HAI-1 [9,10,18]. Therefore, we examined...
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Tài liệu Báo cáo khoa học: Pronounced adipogenesis and increased insulin sensitivity caused by overproduction of prostaglandin D2 in vivo pptx
... investigations that includeanalysis of pancreatic islet cells.The H-PGDS TG mouse is a novel obesity modelwith which to investigate the mechanism of adipogene-sis. As is the case for obese people ... et al. (2001) The mechanisms by which bothheterozygous peroxisome proliferator-activated receptorgamma (PPARgamma) deficiency and PPARgammaagonist improve insulin resistance. J Biol Chem 276,41245–41254.38 ... molecular mecha-nisms underlying adipogenesis may lead to the devel-opment of strategies for reducing the prevalence ofobesity.Adipogenesis is a complex process accompanied by various changes...
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Tài liệu Báo cáo khoa học: Autolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT–MIM interaction pptx
... followed by Strep-tag IIwas isolated by BamHI digestion and inserted into theBamHI site of pmGFP–calpain 7.To construct pCMV3xFLAG–IST1 and pGEX–IST1, anIST1 cDNA fragment was amplified by PCR, ... autolysis. Therefore, it is prematureto draw conclusions regarding the mechanism of theenhancing effects of IST1 on mGFP–calpain 7–Strepautolysis in vitro.Both mGFP–calpain 7 and IST1 have ... FLAG–IST1 did notenhance the autolysis of mGFP–calpain 7 in culturedcells. On the other hand, overexpression of FLAG–IST1DMIM1,2suppressed the autolysis. This observationmight be explained by...
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Tài liệu Báo cáo khoa học: Reversible tetramerization of human TK1 to the high catalytic efficient form is induced by pyrophosphate, in addition to tripolyphosphates, or high enzyme concentration ppt
... Kmvalues is exclu-sively displayed by the tetramer forms, and low-efficiency kinetics with high Kmvalues is displayed by the dimer forms. These observations strengthen theprevious hypothesis that ... Km is the Michaelisconstant and K0.5 is the substrate concentration wherev = 0.5 Vmax. When n = 1, there is no co-operativity, andK0.5= Km.AcknowledgementsThis work was supported by ... behaviour after dilution to 6 lgÆmL)1indicate thatdissociation of the tetramer to the dimer is a slowlyprogressing process. This is supported by the kineticbehaviour of the recombinant enzyme...
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Tài liệu Báo cáo khoa học: Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) scaffold multi-PDZ domain protein 1 pptx
... wasdetected using MUPP1 antibodies.ImmunohistochemistryMice were raised and maintained according to governmen-tal and institutional care instructions. Immunohistochemis-try was carried out on 14 lm ... different odorant molecules is governed by the diverse array ofolfactory receptors expressed by olfactory sensory neurons in the nasalepithelium. Olfactory receptors consist of seven transmembrane ... betweenMUPP1 and OR2AG1 is inhibited by over-expressingthe interacting PDZ domains, the resulting response ofOR2AG1 to odorant is modified in that the rapiddecay of signal is impaired.We finally...
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Tài liệu Báo cáo khoa học: Phosphorylation of cyclin dependent kinase 4 on tyrosine 17 is mediated by Src family kinases pptx
... cancer. The activity of cyclin dependentkinase 4 is controlled by multiple mechanisms, including phosphorylationof tyrosine 17. This site is equivalent to tyrosine 15 of cyclin dependentkinase ... in HeLa lysates. C-YES is a 62 kDa nonreceptor tyrosine kinase of the Srcfamily that is expressed in a wide range of tissues [24].The N-terminus of C-YES is dually myristoylated andpalmitoylated ... thyroid epithelial cells: activation by TSH, inhi-bition by TGFbeta, and phosphorylations of itssubunits demonstrated by two-dimensional gel electro-phoresis. Exp Cell Res 291, 135–149.35 Sexl...
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Tài liệu Báo cáo khoa học: Staphylococcal enterotoxin C1-induced pyrogenic cytokine production in human peripheral blood mononuclear cells is mediated by NADPH oxidase and nuclear factor-kappa B doc
... aureus is a major food- borne pathogenwhich produces a number of toxins and virulence fac-tors [1]. The staphylococcal enterotoxins produced by S. aureus are known to cause staphylococcal food poisoning, ... cytokine synthesisand febrile response induced by SEC1 is dependent onNADPH oxidase and not on PI3K ⁄ Akt or 5-LOX ⁄FLAP because these phenomena are attenuated by apocynin and not by ETYA, MK ... andIL-6 that is blocked by the NF-jB inhibitor (PDTC orSN-50). Moreover, the NF-jB binding ability is abro-gated by binding site competition and antibody super-shift analysis. These findings...
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Tài liệu Báo cáo khoa học: Aggregative organization enhances the DNA end-joining process that is mediated by DNA-dependent protein kinase pdf
... precipitated DNA was analyzed by 1% agarose gel electro-phoresis. DNA was visualized by staining with ethidium bromide. Results are represented by negative images. Asterisks indicate nucleicacids ... and were isolated as a single peak fraction by a 0.1–1.0 m NaCl linear gradient in R buffer. Histone H1,which exists in the DNA affinity fraction, was separated asa major component stepwise elution ... nuclear focilinked to phosphorylated histone H2AX (c-H2AX) [3],which is responsible for the redistribution of repairfactors to DSB sites [4], although it is dispensablefor initial damage recognition...
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