bacteria as a therapeutic approach in cancer therapy
Báo cáo y học: "B cells as a therapeutic target in autoimmune disease" doc
... non-Hodgkin’s lymphoma as a single agent as well as in combination therapy, emphasizing its high B-cell-depleting potency [8] In patients with lymphoma, rituximab infusion is frequently associated ... the US National Institutes of Health is in the planning stage 132 Although autoantibodies in autoimmune cytopenias and some other diseases, such as pemphigus and myasthenia gravis, have a direct ... immunoglobulin levels are usually maintained, possibly as a consequence of plasma cells being spared B-cell depletion in antibody-mediated diseases It is understandable that rituximab has been most...
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Báo cáo khoa học: "Eag and HERG potassium channels as novel therapeutic targets in cancer" docx
... (neuroblastoma) [43] and MCF-7 (breast cancer) cell lines and various cancers such as gliomas [44], cervical cancers [45], colon carcinoma [46], gastric cancers [47] and sarcomas [48] HERG channels have been ... perinuclear localisation of the channel leading to activation of Mitogen activated protein kinase (MARP) pathway resulting in increased cell proliferation The Eag channels also act through the Ca calmodulin ... Subsequently a slow activating potassium channel current similar to rat Eag (rEag) in neuroblastoma cells (h-Eag) was characterised and it was demonstrated that the electrical current was reduced...
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Báo cáo y học: "A rational approach to cancer therapy" pot
... an alternative pathway, in this case base excision repair This combination results in the cells sustaining fatal genomic instability In elegant work that has recently been published, Ashworth’s ... cell, already sensitized to DNA damage by loss of BRCA1/2, is overwhelmed by the combination of a chemotherapeutic agent that causes DNA damage and a compound that prevents DNA repair through an alternative ... shape, for example Understanding of pathways leading to targeted and combination therapies How biochemical pathways can be used to find new therapeutics was illustrated by David Lane (University...
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Bacteria in cancer therapy: a novel experimental strategy ppsx
... malignant astrocytoma in a phase I clinical trial [51] Page of Bacteria as immunotherapeutic agents Immunotherapy for cancer offers great promise as an emerging and effective approach Since tumors are ... death In vitro as well as in vivo studies have revealed that BCG/CWS in combination with ionizing radiation (IR) is a promising therapeutic strategy for enhancing radiation therapy in colon cancer ... [60] All these findings indicate the promising potential of nonvirulent bacteria as cancer immunotherapeutic agents Bacterial spores The majority of all the anaerobic bacteria discussed so far can...
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Báo cáo khoa học: A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer pot
... microRNA polycistron as a potential human oncogene Nature 435, 828–833 39 Hayashita Y, Osada H, Tatematsu Y, Yamada H, Yanagisawa K, Tomida S, Yatabe Y, Kawahara K, Sekido Y & Takahashi T (2005) A ... survival in patients with pancreatic cancer [53] Similarly, overexpression of specific miRNAs was an independent prognostic variable associated with advanced disease stage and decreased survival in patients ... tissues in various cancer types, including CLL, breast cancer, glioblastoma, thyroid papillary carcinoma, hepatocellular carcinoma, lung cancer, colon cancer and endocrine pancreatic tumors [8,17–22,26,45,52–54]...
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Báo cáo khoa học: Quantitative assessment of the glyoxalase pathway in Leishmania infantum as a therapeutic target by modelling and computer simulation pot
... Sousa Silva et al The glyoxalase pathway in Leishmania infantum Table Glyoxalase I kinetic parameters in Leishmania infantum and other cells Initial rate analysis Glx I Substrate Km (mM) Leishmania ... 1,2-diaminobenzene and using 2,3-dimethylquinoxaline as internal standard [36] Methylglyoxal synthase activity was assayed by measuring methylglyoxal formation from DHAP The reaction occurred in ... the glyoxalase pathway in Leishmania braziliensis dates from 1988 [12] Only 16 years later was glyoxalase II characterized in Trypanosoma brucei [13] In this case, lactoyltrypanothione was found...
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Báo cáo hóa học: "IL-2 as a therapeutic target for the restoration of Foxp3+ regulatory T cell function in organ-specific autoimmunity: implications in pathophysiology and translation to human disease" doc
... polymorphisms in the IL2RA gene are associated with age at diagnosis in late-onset Finnish type diabetes subjects Immunogenetics 2010, 62:101-107 36 Kawasaki E, Awata T, Ikegami H, Kobayashi T, Maruyama ... Bernasconi A, Marino R, Ribas A, Rossi J, Ciaccio M, Oleastro M, Ornani A, Paz R, Rivarola MA, Zelazko M, Belgorosky A: Characterization of immunodeficiency in a patient with growth hormone insensitivity ... T, Nakanishi K, Shimada A, Uga M, Kurihara S, Kawabata Y, et al: Genetic association between the interleukin-2 receptor-alpha gene and mode of onset of type diabetes in the Japanese population...
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targeting cancer cell metabolism as a therapeutic strategy
... lyase ACN, aconitase ADP, adenosine diphosphate ALD, aldolase ALT, alanine transaminase AKT, protein kinase B AML, acute myeloid leukemia AMP, adenosine monophosphate AMPK, AMP activated protein ... suppressors AcetylCoA, Acetyl Coenzyme A; ACL, ATP citrate lyase; ACN, aconitase; ADP, adenosine diphosphate ; ALD, aldolase ; ALT, alanine aminotransferase; ATP, adenosine triphosphate; CS, citrate ... usually an essential amino acid in humans due to the presence of asparagine synthetase (ASSN), certain tumour types like leukaemia have little ASSN activity and require exogenous asparagine This has...
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Polo like kinase 1 in hepatocellular carcinoma clinical significance and its potential as a therapeutic target
... in this phase has been identified as a possible target of ataxia telangiectasia mutated (ATM) or ATM-related proteins (ATR), the transducers of the DNA damage signaling pathway (van Vugt et al., ... buffer was added and supernatant was subsequently transferred to a microplate that was coated with anti-caspase-3 for hour at 37oC Substrate solution was then added for hours at 37oC after a washing ... hours after transfection Caspase-3 activity assay was carried out (Fig 8) and intrigued to find that caspase-3 activation in si-PLK1 transfected Huh-7 was absent in the first 12 hours and 24...
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Báo cáo y học: "Gain of a 500-fold sensitivity on an intravital MR Contrast Agent based on an endohedral Gadolinium-Cluster-Fullerene-Conjugate: A new chance in cancer diagnostics"
... Today 2002; 7: 555-62 28 Li X, Wang J, An Z, et al Optically imageable metastatic model of human breast cancer Clin Exp Metastasis 2002; 19: 347-50 29 Massoud TF, Gambhir SS Molecular imaging in ... trifluoroacetic acid in water (A) and 60% acetonitrile in water (B) as eluent The conjugate was eluted with a successive linear gradient, increasing from 25% to 60% B-eluent in 49 at a flow rate of ... slowly added at 0–5°C The resulting deeply colored solution was maintained at room temperature for h Then the organic phase was washed with water, followed by 1N-HCl and again water The organic layer...
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a holistic approach in coastal management
... Improvement works layout plan CAFEO 28 Hanoi, Vietnam (18-22nd Dec 2010) Coastal Management - Beach Rehabilitation At Pulau Tioman, Malaysia Figure - Cascaded Seawall Design Plate -Cascaded Granite Block ... dredging Water Quality Study A detailed water quality study was carried out at the main rivers discharging into the coastal water The study included sampling of water quality parameters at strategic ... needed safe navigation and boat mooring and berthing infrastructures (Plate 8) The boating facilities has the capacity to accommodate at least 102 nos of boats The berthing facility consists of a floating...
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Motivation as a Contributing Factor in Second Language Acquisition
... the individual difference variables alters For example, in a formal setting intelligence and aptitude play a dominant role in learning, while exerting a weaker influence in an informal setting ... university graduation, applying for a job, requesting higher pay based on language ability, reading technical material, translation work or achieving higher social status Instrumental motivation is ... of the amount of time spent studying the language and then output, expressed as linguistic performance when investigating language learning In order to examine language learning in the Japanese...
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A contrastive analysis of encouraging as a speech act in english and vietnamese
... English as an international language in this century, there are a great number of the Vietnamese people who learn and speak English In fact, in learning English as a foreign language, the Vietnamese ... research is intended to deal with the followings: - To find out the common strategies of encouraging in Vietnamese as a speech act A CONTRASTIVE ANALYSIS OF ENCOURAGING AS A SPEECH ACT IN ENGLISH ... plan, saying sorry, attending summer holiday situations Meanwhile, VNS used greater number of strategies in interview preparation and familiar situations than in the familiar situations whereas...
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Reiteration as a cohesive device in news in brief on iraq war in english press = phép lặp làm phương tiện liên kết trong tin vắn về chiến tranh i rắc trên báo chí tiếng anh
... While a lead is always a separated paragraph and usually made up by one sentence, a body often includes more than one paragraph The table below shows the average length of a body in all the news -in- brief ... Conclusion In this part, principal findings are summarized and some practical applications as well as some suggestions for further researches are provided Reiteration as a cohesive device in news -in- brief ... semantic relationships like in the following example: ‘Put that gun down,’ said one of the lawyers at the table His name was Rafter He was a hard man in a courtroom, maybe the hardest lawyer that...
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Tài liệu Supporting Children Learning English as a Second Language in the Early Years (birth to six years) docx
... English as a Second Language in the Early Years (birth to six years) but also includes the development of communicative aspects such as attracting and sustaining attention, managing interactions in ... maintaining the first language include: • playing picture lotto, bingo and card games, using two languages or playing in a language other than English 11 Supporting Children Learning English as ... for participating in classroom activities, and for obtaining, processing, constructing and providing information In the early stages of learning English as a second language children should hear...
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Báo cáo khoa học: The hinge region operates as a stability switch in cGMP-dependent protein kinase Ia doc
... conformational change induced by cGMP binding is thought to induce the release of the autoinhibitory domain from the active site, thereby activating the kinase This is indicated by a remarkable increase ... of a similar enzyme from the AGC-family of protein kinases, cAMP-dependent protein kinase (PKA) have greatly contributed to our understanding of PKG’s intra- and inter-domain interactions, particularly ... results Stoichiometry (native ESI-MS) Average mass calculated (Da)b Mass measured LC-ESI-MS Mass measured ESI-MS (native) (Da) a W15-peptide TQAKRKKSLAMA [30] ine c As previously measured [31] b R77L...
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Báo cáo khoa học: The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer’s disease pptx
... hyperphosphorylation occurs because of an imbalance in the activity of tau kinases and phosphatases [3] One particular tau kinase pertinent to metal dyshomeostasis in AD is glycogen synthase kinase-3 ... decreased availability of intracellular Cu [83] and up-regulated by increased availability of Cu [84] Collectively, these data present a strong case for the native role of APP ⁄ Ab in regulating intracellular ... regard is of particular relevance These authors demonstrated that an increase in oxidative stress alters APP processing and generates an increase in Ab production If an oxidative stressinduced increase...
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ONCOGENOMICS AND CANCER PROTEOMICS – NOVEL APPROACHES IN BIOMARKERS DISCOVERY AND THERAPEUTIC TARGETS IN CANCER pot
... Jamshidi and Clark C Chen Chapter MicroRNAs in Invasion and Metastasis in Lung Cancer Lili Jiang and Xueshan Qiu Chapter The Importance of Cancer Cell Lines as in vitro Models in Cancer Methylome Analysis ... was identified in Chinese women In a pooled analysis study performed in the East Asian, European, and African ancestries, this variant was also found to be associated with breast cancer risk in ... [51] Nakayama N, Nakayama K, Yeasmin S, Ishibashi M, Katagiri A, Iida K, et al KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer Br J Cancer...
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nanocarriers as an emerging platform for cancer therapy
... may be necessary In the case of circulating cancer cells, as in leukaemia and lymphoma, a therapy that targets surface antigens with high affinity and includes a carrier with a long circulating ... Doxorubicin, Paclitaxel In vivo Micelles (lipid based and polymeric) (5–100) Doxorubicin Clinical trials (Phase I) Paclitaxel Clinical trials (Phase I) Platinum-based drugs (carboplatin/ cisplatin), ... in mesothelioma, ovarian and acute lymphoblastic leukaemia Adenocarcinoma of the oesophagus, 5, 91, 100, 101 metastatic breast cancer and acute lymphoblastic leukemia 73, 74 Metastatic or recurrent...
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ADVANCES IN CANCER THERAPY potx
... express Fas Receptor (FasR; CD95) and Fas ligand (FasL; CD95L) that allow them to induce apoptosis in target cells Several cancer types including colon and ovarian carcinoma and melanoma cells ... leaflet with clathrin and ubiquitin-binding proteins, such as Golgiassociated, -adaptin homologs, Arf-binding (GGA) proteins, to form an endosomal clathrin coat that recruits monoubiquitinated ... Curcumin 345 Varisa Pongrakhananon and Yon Rojanasakul Chapter 17 Salograviolide A: A Plant-Derived Sesquiterpene Lactone with Promising Anti-Inflammatory and Anticancer Effects 369 Isabelle Fakhoury...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha thông tin liên lạc và các dịch vụ