and increased knowledge of the human understanding of how the operation of the physical world surroundings through controlled methods
Tài liệu Báo cáo khoa học: Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 docx
... spectrophotometric methods. Because the enzymatic activity of PRTFDC1towards hypoxanthine and guanine is only 0.26% and 0.09%, respectively, of the activity of HPRT, the role of the PRTFDC1 in purine ... II. The hood domain is mainly builtup by residues from the C-terminus and consists of atwo-stranded anti-parallel b-sheet composed of b2 and b9 and an a-helix from the C-terminus (Fig. 1A). The two ... interacts with bothO6 and N7 (Fig. 1C). The 2¢OH of the ribose is hydro-gen bonded to the main chain and the side chain of Asp142 (Fig. 1C). Both hydroxyl groups of the riboseare involved...
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Tài liệu Báo cáo khoa học: Characterization of human deoxyribonuclease I gene (DNASE1) promoters reveals the utilization of two transcription-starting exons and the involvement of Sp1 in its transcriptional regulation ppt
... fragments F and I. The number at the right of each RT-PCR product represents the length of the prod-uct. The scheme also shows the location of the reverse primerDN+89 used in another starting ... and quantitativereal-time RT-PCR, the locations of the primers DN)105 and DN)9used in ChIP assays, the locations of the primers DN+232 and DN+254 utilized in 5¢-RACE, and the locations of the ... numbers over the diagrams indicate the position of the corresponding nucleotides relative to the translation start site, and the numbersin parentheses below the diagram show the position of the corresponding...
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Tài liệu Báo cáo khoa học: Roles of the human Rad51 L1 and L2 loops in DNA binding doc
... permonomer of poly(dT), showing that the changes weremainly due to the binding of the first DNA, while the binding of the second DNA had less influence(Fig. 5A). To ensure that the estimation of the ... fluorescence of tryptophan probes inserted in the L1 and L2 loop upon binding of nucleotides and DNA. The fluorescence of modified Rad51 was measured after the addition of the indicated element. The wavelength ... RecA [16], and the identification of these sites is important for under-standing the reaction mechanism and the regulation of homologous recombination.So far, the crystal structures of bacterial...
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Tài liệu Báo cáo khoa học: Topology, tinkering and evolution of the human transcription factor network doc
... analysis of the topological modules of the Fig. 3(labelled A–G) shows that they include structural and ⁄or functional features. Table 3 summarizes the main structural and functional features of thesegroups. ... functions, and topologi-cal features retain functionality and phylogeny. How- ever, the nature of the connections between thesefactors needs to be understood at the level of the pro-tein domain. The ... compares the studied network withrandomized versions of it with the same size and degree dis-tribution. The so-called Z-score quantifies the differencebetween the studied network and an ensemble of...
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Tài liệu Báo cáo khoa học: Altered expression of CD1d molecules and lipid accumulation in the human hepatoma cell line HepG2 after iron loading pptx
... of the CD1d protein bands indicatedwas performed using a Kodak Digital Science DC40 camera and its associated software. Band intensities are shown on the right and areexpressed as the sum of ... proliferation of stelleatecells and synthesis of collagen [36,37], the in vitro datapresented here may be relevant for understand some of the complex mechanisms responsible for the develop-ment of fibrosis ... byHultcrantz and collaborators showed that iron accu-mulation in the liver of hemochromatosis patients isassociated with oxidative stress and increased expres-sion of ICAM-1 [13]. On the other hand,...
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Tài liệu Báo cáo khoa học: Characterization of promoter 3 of the human thromboxane A2 receptor gene A functional AP-1 and octamer motif are required for basal promoter activity docx
... HEL (C and D; lane 1) and HEK293 (C and D; lane 2) cells. The positions of the molecular size markers (kDa) are indicated to the left and right of the (C) and (D),respectively, whilst the position ... Transcriptional activation of the human hemato-poietic prostaglandin D synthase gene in megakaryo-blastic cells. Roles of the oct-1 element in the 5¢-flanking region and the AP-2 element in the untranslated ... (Prm)3within the human TXA2receptor (TP) gene thatdirects expression of TPb in HEL92.1.7 and HEK293cells [25]. A schematic of the human TP gene highlight-ing the positions of the previously...
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Tài liệu Báo cáo khoa học: "Predicting the fluency of text with shallow structural features: case studies of machine translation and human-written text" doc
... were often the same—readability/fluency of the sentence is important for understanding the sentence. Only after the assessor has understood the sentence can (s)he judge how it compares to the human ... indepen-dent of each other. Fluency was judged directly by the assessors, while adequacy was meant to assess the content of the sentence compared to a human gold-standard. Yet, the assessments of the ... production and a model in-volve the use of syntax, but even in these cases flu-ency is only indirectly assessed and the main ad-vantage of the use of syntax is better estimation of the semantic...
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Báo cáo khoa học: Activation of nematode G protein GOA-1 by the human muscarinic acetylcholine receptor M2 subtype Functional coupling of G-protein-coupled receptor and G protein originated from evolutionarily distant animals doc
... no.NM138736) as the most similar Ga in mammals. The amino acid sequence of GOA-1 is 82.2% identical tothat of Gao. Although the similarity of the aA–aEregion and the region upstream of a4 was relativelylow, ... are the a2 helix, the b6 ⁄ a5 loop, the a5 helix and the N- and C- extreme termini [31]. In addition, the a4helix and a4 ⁄ b6 loop region of Gai1are important forspecific recognition of receptors ... elegans. However, gar-3 isexpressed only in the pharynx and controls pharyngealpumping [40], indicating that the side effect of the acti-vation of GAR-3 is limited. Furthermore, the pheno-type of...
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Báo cáo khoa học: Adenine nucleotides inhibit proliferation of the human lung adenocarcinoma cell line LXF-289 by activation of nuclear factor jB1 and mitogen-activated protein kinase pathways doc
... activation of the NF-jB1isoform of transcription factor NF-jB, the MAPKsERK1 ⁄ 2 and p38 and PI3K. Thus, extracellular nucle-otides need to be added to the class of the critical reg-ulators of cell ... per-centages of the cells in the G0 ⁄ G1, S and G2 ⁄ M phases of the cellcycle after treatment with 20 lM or 100 lM ATP for 24 h. The gat-ing used for the quantification of the cells in the G0 ⁄ ... translocation of ERK1 ⁄ 2 to the nucleus. The translocation of activa-ted ERK1 ⁄ 2 to the nucleus is a prerequisite for the control of cell cycle progression [39,40]. The significance of ERK and p38...
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Báo cáo khoa học: The stop transfer sequence of the human UDPglucuronosyltransferase 1A determines localization to the endoplasmic reticulum by both static retention and retrieval mechanisms docx
... both the ER and the perinuclear region (data not shown). Thesefindings suggest that the proteins may be sorted within the secretory pathway based on interactions betweentheir TMDs and the surrounding ... residues or by extending the length of the cytoplasmic tail to relocate the dilysine from the crit-ical positions )3 and )5 to positions )14 and )16affected the ER localization of the recombinantCD4–TMD ... localization in the ER [19]. We found that the TMD of UGT1A pro-teins appended to the C-terminus of the ectodomain of CD4 plasma membrane glycoprotein was able to retain the chimeric protein in the ER...
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Báo cáo khoa học: Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly ppt
... the C-termini of certain secretoryproteins and act as anchors to attach such proteins to the outer face of the plasma membrane [1,2]. Synthesis of GPIs is essential for cell wall formation and ... but one of the predicted reactions in the GPI pathway. The exception is the addition of the second mannose to the GPI core. We show here thatdepletion of the essential, multispanning membraneprotein ... [19], and the PIG-B ⁄ Gpi10 proteinsfor addition of Man3 [20–22]. However, a candidateGPI-MT-II has not yet been identified from anyorganism and the transfer of Man2 to GPI glycansremains the...
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Báo cáo khoa học: Solution structure and backbone dynamics of the XPC-binding domain of the human DNA repair protein hHR23B docx
... further our knowledge withrespect to the mechanisms of action of these proteins,it is crucial that we define the precise boundaries of the STI1-homologous domain and compare the struc-tures of ... side chains of residues with orientations that differ between hHR23B and hHR23A are shown. Also, b-N and b-C are the N- and C-termini of XPCB–hHR23B; a-N and a-C are the N- and C-termini of hHR23A.B. ... valuescombined with the presence of internal motion and the exchange terms in N-terminal segment show that the N-H vectors of each residue of this region are correla-ted in motion on the axis of helix...
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![Báo cáo khoa học: Epoxidation of benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 in reconstituted membranes Effects of charge and nonbilayer phase propensity of the membrane pot](https://media.store123doc.com/images/document/14/rc/ld/small_ldo1394248806.jpg)
Báo cáo khoa học: Epoxidation of benzo[a]pyrene-7,8-dihydrodiol by human CYP1A1 in reconstituted membranes Effects of charge and nonbilayer phase propensity of the membrane pot
... affect the stereoselectivity of epoxidation. The presence of the anionic lipid PtdSer increased the formation of DE2 twice as much as that of DE1. Even the relatively small portion of the negativelycharged ... i.e.they do not alter the stereoselectivity of epoxidation.Obviously, there is no alteration of the active s ite confor-mation of P450. But the s triking parallelism of the curves in the Lineweaver–Burk ... the conformation of the 9 ,10-epoxy-group, anti in DE2 and synin DE1. The respective data in F ig. 1 B and Table 1 showFig. 1. Effect of phospholipids on the total epoxidation (A) and the ratio of diolepoxide-2...
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Hampering the Human Hacker and the Threat of Social Engineering pptx
... can ensure the integrity of their data and the privacy of their customers.Hampering the Human Hacker and the Threat of Social EngineeringUsing automation to protect your customers and your ... but are often the most damaging. Companies can however, begin the process of stopping social engineering attacks in their tracks by understanding how social engineering tactics work and training ... Voxeo’s ANI Spoof Detector analyze the phone number of incoming calls to determine if the Caller ID/ANI is spoofed. If the number has been spoofed, the call is rejected and never reaches the called...
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- have been studied as potential key molecules in the pathogenesis of the precancerous intestinal metaplasia of the human stomach however
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