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a critical review of the role and limitations of jak inhibitors in myelofibrosis therapy

Báo cáo khoa học:

Báo cáo khoa học: "Lymphatic mapping and sentinel node biopsy in gynecological cancers: a critical review of the literature" pot

Báo cáo khoa học

... in the parametrial areas [35], whereas Levenback found 9% of the sentinel nodes in the paraaortic area, 11% in the common iliac, 71% in the external iliac, and 9% in the parametrial area in a ... Although majority of the nodes are located in internal iliac and external iliac areas, nodes have been found in also presacral, parametrial and pararectal areas [33] In a sentinel node study carried ... 90% are squamous cell carcinomas, while the rest are melanoma, adenocarcinoma, basal cell carcinoma and sarcoma [7] Nodal metastasis in vulva cancer is the main prognostic factor, irrespective of...
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Báo cáo y học:

Báo cáo y học: "A critical review of the research literature on Six Sigma, Lean and StuderGroup''''s Hardwiring Excellence in the United States: the need to demonstrate and communicate the effectiveness of transformation strategies in healthcare" pdf

Báo cáo khoa học

... ever increasing capacity for continuing improvement Improving evaluation and understanding of the implementation and outcomes of such changes are essential to sustaining ongoing transformation and ... developed from the transformation are retained and transferred to other problems and parts of the healthcare organization The two exceptions to the question of sustainability are Furman and Caplan's report ... Implementation Science 2009, 4:35 zation-wide training and leadership behavior modeling to bring about significant cultural change and quality and financial gains In contrast to the number of transformational...
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báo cáo khoa học:

báo cáo khoa học: " A critical review of the research literature on Six Sigma, Lean and StuderGroup''''s Hardwiring Excellence in the United States: the need to demonstrate and communicate the effectiveness of transformation strategies in healthcare" pot

Báo cáo khoa học

... ever increasing capacity for continuing improvement Improving evaluation and understanding of the implementation and outcomes of such changes are essential to sustaining ongoing transformation and ... developed from the transformation are retained and transferred to other problems and parts of the healthcare organization The two exceptions to the question of sustainability are Furman and Caplan's report ... Implementation Science 2009, 4:35 zation-wide training and leadership behavior modeling to bring about significant cultural change and quality and financial gains In contrast to the number of transformational...
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Báo cáo khoa học: What’s in a covalent bond? On the role and formation of covalently bound flavin cofactors doc

Báo cáo khoa học: What’s in a covalent bond? On the role and formation of covalently bound flavin cofactors doc

Báo cáo khoa học

... Plant VAO VAO VAO VAO VAO VAO VAO VAO VAO VAO VAO VAO VAO VAO VAO VAO VAO VAO VAO VAO GMC GMC GMC Succinate dehydrogenase Succinate dehydrogenase DAAO DAAO DAAO DAAO ? ? VAO AMO AMO DAAO DAAO ... Plant Plant Bacteria Plant Plant Fungus Bacteria Bacteria Bacteria Plant Bacteria Animal Fungus Yeast Yeast Bacteria Bacteria Plant Bacteria Fungus Fungus All Bacteria Animal Animal Bacteria Bacteria ... in black, FAD in black and gray, and known linking amino acids in green Sites of covalent attachment are indicated by arrows The numbering of some isoalloxazine atoms is indicated (B) Types of...
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Báo cáo y học:

Báo cáo y học: "The treatment of condylar fractures: to open or not to open? A critical review of this controversy" pdf

Báo cáo khoa học

... objective of analyzing the main variables that determine the choice of the method of treatment and the outcome in condylar fractures, Villarreal et al.24 conducted a retrospective analysis of 104 mandibular ... choose a surgical approach that can minimize the amount of soft tissue stripping from the fractured condylar process and retain attachment of the TMJ capsule and the lateral pterygoid muscle as far ... B, Abubaker AO, Laskin DM A comparative study of mandibular fractures in the United States and Turkey Int J Oral and Maxillofacial Surgery 2007; 36: 395-7 Long X, Goss AN A sheep model of intracapsular...
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Báo cáo y học:

Báo cáo y học: "A short review on the aetiology and pathophysiology of alcoholism" ppt

Báo cáo khoa học

... model of the parents, especially the parent of the same sex seems to be significant Operant conditioning is related to the increase of satisfaction and the decrease of unpleasant feelings (uneasiness, ... mesolimbic pathway is considered crucial for the reward procedure This pathway starts from the ventricular area, which is an area rich in dopamine in the midbrain (the ventral tegmental area (VTA)) [1,22] ... related to addiction such as tolerance, sensitivity, dependence and so on, are the results of a molecular and cellular adaptation which takes place in specific brain areas as a results of repeated...
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Báo cáo khoa học:

Báo cáo khoa học: "A critical review of larch hybridization and its incidence on breeding strategies" potx

Báo cáo khoa học

... rates comparable to other vigorous species such as Douglas fir and an apparent wide soil adaptability on Rational use of the parental populations and their evaluation through hybridization as ... necessary to determine the relative pro- portion of dominance to additivity of the traits, their level of inheritance and correlations, and their stability over time and space There would appear ... crossing of individuals, and its early evaluation through sexual or vegetative propagation A short-term breeding strategy using early tests might give rapid and substantial gains (Table II, with the...
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báo cáo khoa học:

báo cáo khoa học: " Can one puff really make an adolescent addicted to nicotine? A critical review of the literature" potx

Báo cáo khoa học

... coding and interpretation of the data In addition to the methodological flaws noted above, several of the studies we reviewed were marred by biased coding and interpretation of the data For example, ... studies in this research program, noting their major findings as well as major questions that these findings raise We follow by critically examining the conceptual and empirical basis for the claims ... effortless exercise of free will” is untenable Many human behaviors are habitual and automatic rather than intentional and willful, so that both performing and discontinuing them is rarely “an effortless...
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Báo cáo khoa học:

Báo cáo khoa học: "Clinical review: A systematic review of corticosteroid use in infections" ppt

Báo cáo khoa học

... trial of paediatric meningitis in a developing country with late presentation of disease, high levels of resistance to available antimicrobials, and a higher prevalence of chronic disease and malnutrition ... deterioration in pulmonary function after initiation of antimicrobials The efficacy of adjunctive corticosteroid therapy in avoiding this complication was investigated, leading to a consensus statement ... diethlycarbamazine is used there is a significantly increased chance of reaction to the lysed microfilariae This Mazzotti reaction comprises itching, rash, fever, tachycardia and hypotension, and...
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A critical analysis of environmental governance in urban china a case study of nanjing

A critical analysis of environmental governance in urban china a case study of nanjing

Tổng hợp

... ‘small’, ‘rural’ and ‘sparsely populated’ are irrelevant to the meaning of ‘urban’ Further, in light of ‘urban’ as a spatial scale, ‘urban’ does not refer to an international arena, a nation state, ... by placing 12 collaborative planning an integral part of environmental governance in urban China, arguing that collaborative planning is a very promising form that will enable China to realize ... process in Nanjing and how they have been (and can be) mediated both in Nanjing, and more broadly, in urban China as well In short, this thesis is an attempt to reframe the prevailing critiques that...
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báo cáo khoa học:

báo cáo khoa học: "Targeting tumorigenesis: development and use of mTOR inhibitors in cancer therapy" ppsx

Báo cáo khoa học

... rapamycin was identified as TOR, the mammalian analogue is designated mTOR [4] Rapamycin was analyzed for anticancer activity against a panel of human cancer cell lines by the US National Cancer ... rejection in renal and cardiac transplantation patients in Europe [17-19] The revival of mTOR inhibitor evaluation as anticancer agents began with rapamycin analogues that have a more favorable pharmacokinetic ... 9.6% in stratum and 4.4% in stratum Stable disease was maintained in 68% of patients in stratum and 80% of patients in stratum Median PFS (by central radiology) was 9.7 months in stratum and 16.7...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc

Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc

Báo cáo khoa học

... at higher rates than usual radical rearrangements [98,312] On the other hand, the timing of radical rearrangement (radical clocks) may depend critically on the tightness of the radical cage and ... [68], the enzyme variant still mediated N-oxygenation of the tertiary arylamine at a rate less than half that of the wild-type-catalyzed reaction [142], so that reasonable interpretation of the data ... [106,107] A step forward in the analysis of Fe(III)-OO(H) as a potential catalyst was thought to be offered by the use of mutated P450s, bearing alanine or some other amino acid in place of the highly...
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báo cáo khoa học:

báo cáo khoa học:" Measuring the psychosocial health of adolescent and young adult (AYA) cancer survivors: a critical review" doc

Báo cáo khoa học

... psychological, social, and often spiritual well-being [29] For cancer patients these generally include measures of quality of life (QoL) and Medline, PsychINFO, EMBASE and CINAHL databases were searched ... relevant publications The initial search of the Medline, PsychINFO, EMBASE and CINAHL databases identified a total of 552 publications related to assessing psychosocial outcomes in AYA cancer survivors, ... reported across more than one publication Sample characteristics Overall, reporting of the sample accrual method and the sociodemographic and clinical characteristics of participants for each measure...
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Báo cáo y học:

Báo cáo y học: "A systematic review of the role of vitamin insufficiencies and supplementation in COPD" docx

Báo cáo khoa học

... Vitamin A and B Vitamin A (retinol and carotens) plays an important role in several functions of the human body including vision, bone and skin health, and further has an innate antioxidant activity ... Questionnaires (FFQ) Both measures have their advantages and disadvantages Serum levels of vitamins The assessment of serum levels of vitamins can have the advantage of being more objective than patient’s ... Vitamin B is involved in various steps of metabolism and enhances immunity High levels of vitamin A, b-carotene and/ or alpha-carotene were associated with increase in FEV1 and FVC in most of the...
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Environmental performance and sustainable architecture  a critical review in the context of singapore public housing  2

Environmental performance and sustainable architecture a critical review in the context of singapore public housing 2

Thạc sĩ - Cao học

... matrix of pair-wise comparisons A = (aij) can be established as follows: A1 A2 An A1 a1 /a1 a1 /a2 a1 /an A2 a2 /a1 a2 /a2 a2 /an An an /a1 an /a2 an/an 149 where ai/aj = aj/ai for all ... block The calculation is based on estimates of average annual local rainfall, absorption capacity of site through permeable paving and landscaping (See 6.3.3.) All waste water in the housing block ... weights of a set of criteria (w1, w2, , wn) from that matrix The following is a brief summary of the mathematical theory of the AHP, as reference to Saaty and Vargas (1991) and Harker (1989) The matrix...
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Environmental performance and sustainable architecture  a critical review in the context of singapore public housing  3

Environmental performance and sustainable architecture a critical review in the context of singapore public housing 3

Thạc sĩ - Cao học

... distance of available point that horizontal and downward views are available of the interior of bedroom and living areas of certain percentage of dwelling units of the building Interpreting from ... percentage of greenery area in the site In daylight factor, other constituting components in the measurement include the total area and reflectance of interior surfaces, the total area and average ... performance, the building footprint area (Af) and the percentage of hard-paved area of the site (P) should be kept as low as possible, and the total net usable area of the building (Anet) should be as large...
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Environmental performance and sustainable architecture  a critical review in the context of singapore public housing  4

Environmental performance and sustainable architecture a critical review in the context of singapore public housing 4

Thạc sĩ - Cao học

... criticism and debate' (as in the words of Guy and Farmer, 2001) 329 14.3 Towards sustainable public housing in Singapore In substantiating the main discourse of environmental performance and sustainable ... potential sustainable performance of the project, based on the information available at the end of the Design phase Because the information available during the Pre-Design and Design phases are likely ... few indicators are available in this phase Assessment during the Operations phase is intended to provide an objective and factual indication of the Actual performance of the project, and the...
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Environmental performance and sustainable architecture  a critical review in the context of singapore public housing 1

Environmental performance and sustainable architecture a critical review in the context of singapore public housing 1

Thạc sĩ - Cao học

... Conference in Canada The objective of GBC is not a commercial tool, but rather a research and testing tool acting as a generic framework for global practice and national adaptation In the words of Raymond ... sustainability; on the other hand, stiffens the evolution of understanding and definition of sustainable development, and restrains innovation of strategies towards sustainability Secondly, in ... establish a framework that integrates all these aspects of the study in approaching sustainable housing 1.5.2 Research objectives The driving force of this research is the disintegrating and...
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Tài liệu University Oars Being a Critical Enquiry Into the After Health of the Men Who Rowed in the Oxford and Cambridge Boat-Race, from the Year 1829 to 1869, Based on the Personal Experience of the Rowers Themselves pdf

Tài liệu University Oars Being a Critical Enquiry Into the After Health of the Men Who Rowed in the Oxford and Cambridge Boat-Race, from the Year 1829 to 1869, Based on the Personal Experience of the Rowers Themselves pdf

Sức khỏe giới tính

... life of 389 instead of 320 years, and to each man 48*6 instead of 40 years The Table regarding these two first crews of the year 1829 m a y be calculated up to a still later date, and so may deal ... " About a week before the race I felt a pain in my left arm as if I had got rheumatism, and it became rather stiff till after the race, and then severe inflammation set in, in the elbow-joint, ... impunity the wear and tear of these contests His exertions were of a more than ordinarily trying character, for he had participated in many severe races both on the Thames and at Henley And he was a...
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Nitrosamine and related food intake and gastric and oesophageal cancer risk: A systematic review of the epidemiological evidence ppt

Nitrosamine and related food intake and gastric and oesophageal cancer risk: A systematic review of the epidemiological evidence ppt

Sức khỏe giới tính

... may be related to salt and NOC, in enhancing carcinogenesis after the epithelium is damaged[8] The aim of this article is to review and evaluate the available epidemiological evidence about the ... Nitrosamines and gastroesophageal cancer the metabolism of these chemical compounds and DNA repair potentially related to the risk of cancer, is also useful On the other hand, taking into account ... S, Inoue M, Natsukawa S, Shaura K, Koizumi Y, Kasuga Y, Hanaoka T, Tsugane S Association of Helicobacter pylori infection and environmental factors in non-cardia gastric cancer in Japan Gastric...
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