Tài liệu HPLC for Pharmaceutical Scientists 2007 (Part 1) docx
Tài liệu HPLC for Pharmaceutical Scientists 2007 (Part 1) docx
... arethree basic types of molecular forces: ionic forces, polar forces, and dispersiveforces. Each specific technique capitalizes on each of these specific forces:1. Polar forces are the dominant type ... employedin normal-phase HPLC (see Chapter 5).2. Dispersive forces are employed in reversed-phase HPLC (see Chapter 4).3. Ionic forces are employed in ion-exchange HPLC (see Chapter 4,Section ... performed toadequately control and monitor the quality of the prospective drug candidates,excipients, and final products. Effective and fast method development is of3 HPLC for Pharmaceutical Scientists, ...
- 24
- 417
- 1
Tài liệu HPLC for Pharmaceutical Scientists 2007 (Part 8E) docx
... that was optimized by Drylab, a forced degrada-tion sample was run that was stressed at 50°C for 1 week in pH 1 diluent. Itwas noted that a major impurity was formed (Figure 8-49) and was determinedto ... isocratic conditions for deter-mining the most suitable pH for the method. The retention behavior of activeas a function of pH (isocratic) was determined. The best mobile-phase pH for further gradient ... canΠΠrLrLrr23024630460425.....-i.d.column-i.d.column-i.d.column2-i.d.column2==METHOD DEVELOPMENT APPROACHES 425be performed for further structural elucidation of the impurities. Deuteratedexperiments can be performed to support structural assignments.8.5.7 Case...
- 7
- 314
- 1
Tài liệu HPLC for Pharmaceutical Scientists 2007 (Part 8F) docx
... crystals that willdamage the seal over time. Therefore it is recommended to wash the HPLC system with acetonitrile/water (20:80) for at least 30min before the system isshut down to remove any potential ... of analysis is criticalto the success for fast and effective method development. The generalapproach for the method development for the separation of pharmaceutical compounds was discussed, ... R. Vivilecchia, UPLCTM—Acritical look at system/column performance and method transfer considerations for pharmaceutical analytes, HPLC 2005 Conference, Stockholm, Sweden, 2005.41. NIOSH Manual...
- 26
- 307
- 1
Tài liệu HPLC for Pharmaceutical Scientists 2007 (Part 3) docx
... practically applicable for HPLC support.Chemical modification of the silica surface with hydridosilane-type modi-fiers as shown in schematic (3- 11) offers some advantages:(3- 11) A byproduct of this ... in HPLC are porous particles with averagediameters between 3 and 10µm. For most pharmaceutical applications, 3-µmparticle sizes are recommended. Porosity provides the surface area necessary for ... commercially available HPLC stationary phase is performed by its reaction with alkylchlorosilane-type modifiers, reaction (3-9). HCl is generated as a byproduct, and typicallya scavenger for HCl is employed...
- 64
- 322
- 0
Tài liệu HPLC for Pharmaceutical Scientists 2007 (Part 13) docx
... or microorganisms to screen their spectrum of605 HPLC for Pharmaceutical Scientists, Edited by Yuri Kazakevich and Rosario LoBruttoCopyright © 2007 by John Wiley & Sons, Inc.baseline setup, ... treated as a whole (for more details see www.fda.gov; General Principles of Software Validation;Final Guidance for Industry and FDA Staff, January 11, 2002). The PQ isusually performed prior to ... chiral → chiral transforma-tions—could create critical issues in the interpretation of the metabolism andpharmacokinetics of the drug.Therefore, selective analytical methods for sep-arations...
- 36
- 312
- 0
Tài liệu HPLC for Pharmaceutical Scientists 2007 (Part 14) docx
... is highly unlikely that the synthetic process641 HPLC for Pharmaceutical Scientists, Edited by Yuri Kazakevich and Rosario LoBruttoCopyright © 2007 by John Wiley & Sons, Inc.of blanks injected ... than ELSD [24]. HPLC DETECTORS 655Electrochemical detection can be utilized for compounds that are ionic orreadily oxidizable or reducible.Thus, this form of detection can be used for theanalysis ... prior to analysis byreversed-phase LC [21].14.4 HPLC DETECTORSThe detectors utilized for HPLC are designed to respond to the solute beingeluted. HPLC detectors can be classified into two broad...
- 37
- 345
- 0
Tài liệu HPLC for Pharmaceutical Scientists 2007 (Part 22) docx
... the two sets of crystals, the molecules are987 HPLC for Pharmaceutical Scientists, Edited by Yuri Kazakevich and Rosario LoBruttoCopyright © 2007 by John Wiley & Sons, Inc.mobile phases ... conformation with the N-TFA-α-amino acid isopropyl ester.(Reprinted from reference 36, with permission.)The introduction of the diamide derivatives for enantiomeric separationwas a step forward ... different affinities for the enantiomers of another substance, thena single enantiomer of the latter will have different affinities for the enan-tiomers of the initial selector. In an effort to design...
- 65
- 422
- 0
Tài liệu HPLC for Pharmaceutical Scientists 2007 (Part 7A) pptx
... ions on the basis of mass-to-charge ratios,281 HPLC for Pharmaceutical Scientists, Edited by Yuri Kazakevich and Rosario LoBruttoCopyright © 2007 by John Wiley & Sons, Inc.low-polarity ... the most widely used systems for analysis of large bio-molecules. For a continuous ion source, the ions can be stored for a shortperiod of time and pulsed out for analysis. In the case of ESI, ... structures of analytes. For basic compounds (i.e., amines), apositive ion mode can be used to form a protonated or cationized molecule. For acidic compounds, a deprotonated molecule is formed in the negative...
- 29
- 455
- 3
Tài liệu HPLC for Pharmaceutical Scientists 2007 (Part 7B) pptx
... metabolites areimportant biotransformation pathways for many drugs and xenobiotics [127,132, 133]. For example, the formation of acyl glucuronide conjugate forced thewithdrawal of four marketed ... intermediates for formation of the keto acid, were also observed in the radiochromatogramof rat plasma (spectrum not shown) [131].PRACTICAL APPLICATIONS 335Scheme 11. Mechanism for the formation ... was achieved for the exact mass mea-surements, using PEG sulfates as internal calibration substance. Based on thehigh-resolution MS information, empirical formulae were obtained for allcomponents...
- 37
- 283
- 1
Tài liệu HPLC for Pharmaceutical Scientists 2007 (Part 8A) ppt
... development; these include speed347 HPLC for Pharmaceutical Scientists, Edited by Yuri Kazakevich and Rosario LoBruttoCopyright © 2007 by John Wiley & Sons, Inc. for these studies. Fast gradient ... the ACD prediction of the solubil-ity for the ionized form of bases and acids shows greater deviation than for the solubility predicted for the neutral form of the molecules.Reaction of the ... different solutions prepared at the different pHvalues. For example, in Figure 8-7 if the target concentration for the HPLC assay is 1 mg/mL for this basic compound, then the sample at pH 1 (8 mg/mL356...
- 21
- 327
- 1
Từ khóa: tài liệu tin học văn phòng 2007tài liệu hướng dẫn học access 2007download tài liệu hướng dẫn học word 2007tài liệu hướng dẫn microsoft project 2007tài liệu học microsoft office project 2007tài liệu sử dụng microsoft project 2007Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Nghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngĐịnh tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Thiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíChuong 2 nhận dạng rui roKiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Quản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀM