Báo cáo y học: "PKC and PKA Phosphorylation Affect the Subcellular Localization of Claudin-1 in Melanoma Cells"
Báo cáo y học: "PKC and PKA Phosphorylation Affect the Subcellular Localization of Claudin-1 in Melanoma Cells"
... as α, β and γ (4). In this study, we also examine the effects of PKA on claudin-1 expression and localization, and how the localization of claudin-1 can affect melanoma cell mo-tility. Significance ... modifications of the tight junction protein claudin-1 cause its translocation to the cytoplasm and nucleus and that the subcellular localization of claudin-1 may dictate the metastatic capacity of melanoma ... isoforms using bryostatin instead increased the expression of claudin-1 in the tight junction complex, and increased tight junction barrier integrity (9). In melanoma, we have shown that claudin-1...
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Báo cáo Y học: Kinetic and biochemical analyses on the reaction mechanism of a bacterial ATP-citrate lyase ppt
... protein, indicating that His273 played an essentialrole in the activity of the enzyme, most likely as the residuephosphorylated by ATP. Phosphorylation of Cl-ACL In order to investigate the reaction ... reactionmixture. The results are shown in Table 1. The enzymeexhibited maximum activity in the presence of ATP, and in the presence of dATP showed 40% of this activity. In the presence of CTP, activity was ... Ks1<<Ks2<<Ks3, binding of the first and second molecules of citrate drastically decrease the affinity of the enzyme for the second and third molecules,respectively. The dissociation constant of the first...
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Tài liệu Báo cáo Y học: Human and Drosophila UDP-galactose transporters transport UDP-N-acetylgalactosamine in addition to UDP-galactose doc
... for the conformational stability of the protein and its proper interaction with the membrane protein-sorting machinery. The importance of helix 1 in stabilizing the UGT protein may also be inferredfrom ... the elongation of carbohydrate chains by appropriate glyco-syltransf erase s. Changes in the activities of NSTs may affect the structure of oligosaccharide chains by affecting the availability of substrates ... [24].Heparin-like glycosaminoglycans that contain galactose and N-acetylgalactosamine residues are involved in the winglesssignaling [25]. The DmUGT protein was localized in the GolgiregionwhenthecDNAwasexpressedinLec2andLec8cells,...
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Báo cáo Y học: Thermolysin-linearized microcin J25 retains the structured core of the native macrocyclic peptide and displays antimicrobial activity doc
... to be maintained in the thermolysin-linearizedform. In the cyclic MccJ25, the stability is likely to bereinforced by the constraining strength of the circularbackbone.Interestingly, the stable ... 268,2124–2133]. The molecular mechanisms involved in the biosynthesis, folding and mode of action of MccJ25 are stillunknown. We have investigated the structure and the anti-microbial activity of thermolysin-linearized ... very welldefined, stabilized primarily by the hydrogen bonds of atightly packed b-sheet. In this study, we examined the solution structure,stability, and antimicrobial activity of the thermolysin-linearized...
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Báo cáo y học: "Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients"
... was informed of thestudy purpose and consent was required to further maintainstatus as study participant. The study was performed inaccordance with the declaration of Helsinki and approved bythe ... domain of the Tie2 receptor,which is almost exclusively expressed by endothelial cells.Binding of the agonist Ang-1 to the Tie2 receptor promotesvessel integrity, inhibits vascular leakage and ... arecharacterised by an excess of circulating Ang-2 in the pres-ence of low Ang-1 and VEGF; Ang-2 correlates with severityof illness (APACHE II and SOFA scores), pulmonary dysfunc-tion (PaO2/FiO2 and PaO2) and...
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Báo cáo y học: "Serum cystatin C levels to predict serum concentration of digoxin in Japanese patients
... in this study. The serum levels of Cys-C and Cr in the patients were higher than those in the healthy elderly subjects, but the increase of Cys-C was more predominant in the patients. Their ... 1. Introduction Cystatin C (Cys-C) is a non-glycosylated cationic protein of 13.3 kDa, belonging to the cystatin superfamily of cysteine protease inhibitors [1, 2]. Cys-C is produced by all ... digoxin in Japanese patients. The serum levels of Cys-C and Cr in the patients were higher than those in the healthy elderly subjects, but the increase of Cys-C was more predominant in the patients,...
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Báo cáo khoa học: Structural and thermodynamic insights into the binding mode of five novel inhibitors of lumazine synthase from Mycobacterium tuberculosis pptx
... ⁄TS50. The analysis of the thermodynamic parameters of the different inhibitors clearly showed an increase of the affinity (decreasing of DG) of the compounds bear-ing the alkyl phosphate chain in ... comparison of bindingaffinities of the inhibitors under study. The fitting of the binding isotherms of all five com-pounds with a binding model assuming identical and independent binding sites ... carbonyl oxygen atoms of the pyrimidine ring and the protein chain. Namely, there are two new directhydrogen bonds formed between carbonyl oxygen O1 and the main chain Ala59N and between N1 and Val81O....
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Báo cáo khoa học: Tumour necrosis factor-a attenuates insulin action on phosphoenolpyruvate carboxykinase gene expression and gluconeogenesis by altering the cellular localization of Foxa2 in HepG2 cells pptx
... bycirculating levels of insulin and glucagon [14]. Insulintriggers the activation of a series of phosphorylation cascades that are lost in insulin-resistant states, therebypreventing insulin ... and, in a preliminary investigation using the humanhepatoma (HepG2) cell line in this study, we demonstrated the role of TNFa in the regulation of this phenomenon and determined the underlyingmolecular ... elevated in obesity-associated insulin resistance and diabetes, inhibit insulin signalling atseveral points in the signalling cascade. The liver is critical in maintaining cir-culating glucose...
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Báo cáo khoa học: Temperature and salts effects on the peptidase activities of the recombinant metallooligopeptidases neurolysin and thimet oligopeptidase pdf
... Linear Eyring plots (ln[k/T ]vs.1/T )were obtained for the hydrolysis of Qf 7 by both enzymes and for the hydrolysis of the substrate containing Val byneurolysin. The Eyring plots for the hydrolysis ... hydrolysisby TOP and neurolysin The preference of cleavage at the L–R or R–R bond forTOP and at the R–R or R–X bond for neurolysin in the case of the substrates containing Val, Asp and Ile at the X ... dependence of the catalytic constants accord-ing to the substrates, the positive and high values of DH* and DS* for hydrolysis are of note. In uence of the NaCl on TOP and neurolysin activities The in uence...
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Báo cáo Y học: DAP kinase activity is critical for C2-ceramide-induced apoptosis in PC12 cells ppt
... phosphorylates the regulatorylight chain of myosin II the phosphorylation sites beingthreonine 18 and serine 1 9 [22]. In this study, the syntheticpeptide, skeletal myosin light chain kinase substrate ... (pro line 277 to leucine 323) containing the calmodulin-binding domain. In the K42A-DK mutant, a lysine residue at position 42 in t he kinase domain (asterisk) is replaced by an a lanine. The D ... highly h omologous to that of MLC kinase.Zipper-interacting protein kinase (ZIP kinase), with asequence 81% identical to that of the kinase domain of DAP kinase [20±22], a lso phosphorylates the...
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Từ khóa: báo cáo y họcbáo cáo y học cổ truyềnmẫu báo cáo y học cổ truyềnbao cao y hoc colchicinphan ban luan trong bao cao y hoc co truyenbáo cáo khoa học ảnh hưởng của việc thay thế cỏ xanh trong khẩu phần bằng bã dứa ủ chua đến khả năng sản xuất của bò thịt potBáo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Nghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Thơ nôm tứ tuyệt trào phúng hồ xuân hươngSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXGiáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtChiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015HIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMMÔN TRUYỀN THÔNG MARKETING TÍCH HỢPTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ