Báo cáo y học: "A folate-rich diet is as effective as folic acid from supplements in decreasing plasma homocysteine concentrations"
Báo cáo y học: "A folate-rich diet is as effective as folic acid from supplements in decreasing plasma homocysteine concentrations"
... derived from a combination of folate-rich and fortified foods is as effective as folic acid from supplements in decreasing plasma tHcy concentrations in patients with coronary artery disease (CAD) ... hyperhomocysteinemia were initially included in the study. Hyperhomocysteinemia was arbitrarily defined as tHcy ≥ 12 µmol/l, considering that desirable values of tHcy in CAD patients have been defined as ... therapy. 4. DISCUSSION This study shows for the first time that a moderate daily intake of a variety of folate-rich foods is as effective as folic acid from supplements for lowering plasma tHcy...
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Báo cáo y học: " A Novel Variable Number of Tandem Repeat of the Natriuretic Peptide Precursor B gene’s 5’-Flanking Region is Associated with Essential Hypertension among Japanese Females"
... mainly as cardiac hormones and are produced primarily by the atria and ventricles, respectively, whereas C-type natriuretic peptide is expressed mainly in the brain [4,5]. BNP, which was originally ... Int. J. Med. Sci. 2007, 4 148Statistical analysis Data are presented as the mean ± SD. The Hardy-Weinberg equilibrium was assessed by doing chi-square (χ2) analysis. Differences in the clinical ... BNP assay kit, Shionogi Co., Ltd., Tokyo, Japan) as de-scribed previously [12]. Polymerase chain reaction - single strand confor-mation polymorphism (PCR-SSCP) Genomic DNA was extracted from...
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Báo cáo y học: "A Randomized Study of Epithelial Ovarian Cancer: Is Chemotherapy Useful after Complete Remission"
... study examined 122 randomized patients in complete remission as judged by laparoscopy or laparotomy following first-line chemotherapy consisting of ACy (Adriamycin + Cyclophosphamide), PCy (Cisplatin ... having completed his B.A. in Biochemistry at New York University, is presently in his final year of medical studies at the University of Padua and will pursue resident training in Oncology. His ... 5-FU was reduced by 25%. The first day of 5-FU was abolished in cases of myelotoxicity protracted from the previous cycle (more than 5 weeks to recovery). Cisplatin was reduced by 50% in mononephric...
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Tài liệu Báo cáo Y học: Ornithine decarboxylase-antizyme is rapidly degraded through a mechanism that requires functional ubiquitin-dependent proteolytic activity pot
... their intracellular concentration. One of t hemajor sources of ce llular polyamines c omes from t heirsynthesis from amino acid precursors. In this biosynthesispathway ornithine is decarboxylated ... polyamines serving as markers. The individual polyamines were visualized byUV illumination.RESULTSAntizyme is rapidly degraded by the actionof the 26S proteasomeWhile it is clear that interaction ... in Fig. 2A as in 653 cells antizyme is present in vast excess whereas ODC is practically undetected. Testing for antizyme degradation in cells completely lacking ODC protein will allow d rawing...
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Báo cáo Y học: A Ca2+/CaM-dependent kinase from pea is stress regulated and in vitro phosphorylates a protein that binds to AtCaM5 promoter ppt
... Burny, A. (1993) Acalcium/calmodulin-binding serine/threonine protein kinasehomologs to the mammalian type II calcium/calmodulin-dependent protein kinase is expressed in plant cells. Plant Physiol.101, ... doi:10.1046/j.1432-1033.2002.02994.xof this class of kinase are limited in plants [17–21]. TheCa2+/CaM kinase isolated from maize roots has beenshown to be involved in gravitropism [19] and the Ca2+/CaM kinase isolated from ... molecular mass of 72 kDawas identified in pea. The pea kinase (PsCCaMK) wasupregulated in roots in response to low temperature andincreased salinity. Exogenous Ca2+application increasedthe kinase...
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Báo cáo Y học: A new siglec family member, siglec-10, is expressed in cells of the immune system and has signaling properties similar to CD33 docx
... areembedded in ITIM-signaling motifs (Y5 97 and Y6 67) andare likely involved in intracellular signaling. The ability oftyrosine kinases to phosphorylate the cytoplasmic tyrosineswas evaluated by kinase ... binding ofSHP-1, however, was missing from the Y6 67F mutantindicating this to be the preferred tyrosine for interactionwith SHP-1. SHP-2 binding, however, was only diminishedby < 50% in ... 6. Kinase assays with the siglec-10 cytoplasmic GST fusionconstructs. Tyrosine phosphorylation (minus GST alone) of GST–cyto-wt with individual tyrosine kinases in a cell-free format.Tyrosinephosphorylation...
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Báo cáo Y học: ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3) pdf
... [15].RESULTSP70ik3-1 is phosphorylated by cyclin A/cdk2, cyclin E/cdk2,cyclin A/cdk3 or cyclin E/cdk3 which is produced in thebaculoviral systemWe initially tested a hypothesis that p70ik3-1might ... cdk3-mediatedphosphorylation.Keywords: cdk3; ik3-1; phosphorylation.Mammalian G1 phase progression is regulated by G1 cyclinand cyclin-dependent kinases (cdks). Cdk4 or cdk6 is associated with D-type cyclins ... strongly supporting that Ser274 is phosphorylatedby cyclin/cdk3.Ser274 of ik3-1 also is phosphorylated by cdk3 in vivoNext, we asked whether Ser274 of p70ik3-1 is phosphorylatedby cyclin E/cdk3...
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Báo cáo Y học: A nonphosphorylated 14-3-3 binding motif on exoenzyme S that is functional in vivo pot
... by sequence analysis. Stable induction of proteinexpression in strains grown in the presence of 0.02%L(+)arabinose was confirmed by Western analysis as describedpreviously [44], using polyclonal ... thewild-type ExoS, ExoS(SD), or ExoS(S3).The extent of cytotoxicity as visualized by a distinctchange in cell morphology in vivo was examined in HeLacells taken at 80 min postinfection. As control, ... capacityto ADP ribosylate cytoplasmic proteins, e.g. Ras, and showsa reduced capacity to change the morphology of infectedcells.Keywords: ADP-ribosylation; coenzyme binding site; cyto-toxicity;...
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Báo cáo Y học: A complex fruit-specific type-2 ribosome-inactivating protein from elderberry (Sambucus nigra) is correctly processed and assembled in transgenic tobacco plants doc
... treated with trypsin as described previously [6].The carbohydrate-binding specificity of the type-2 RIPswas checked by inhibition of agglutination of trypsin-treated rabbit erythrocytes with galactose ... agglutination examinedafter 1 h.RNAN-glycosylase activity assayThe RNA N-glycosylase activity of the RIPs was deter-mined by the method of Endo et al. [5] with minormodifications as described ... arelocated in domain 1, and two others (linking Cys147-Cys162 and Cys188-Cys205, respectively) are located in domain 2. The sugar-binding activity of SNA-If relies ontwo carbohydrate-binding sites...
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