Báo cáo y học: "Proteomic analysis of mechanisms of hypoxia-induced apoptosis in trophoblastic cells"
Báo cáo y học: "Proteomic analysis of mechanisms of hypoxia-induced apoptosis in trophoblastic cells"
... proteins induced by hypoxia in trophoblastic cells so as to clarify the mechanism of hypoxia-induced apoptosis by using the PoweBlot, an antibody-based Western array. Human choriocarcinoma cell line ... ap-proach to identify key molecules in the course of hy-poxia-induced apoptotic pathways. Such analysis of trophoblastic cells will, in the near future, yield in- sights into the mechanisms of preeclampsia ... by villous hypoxia, characterized by dimin-ished syncytial differentiation, syncytial knots, and prominent cytotrophoblasts [1]. Hypoxia is known to induce apoptosis in various cells, including...
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Báo cáo y học: " Mutation Analysis of hCDC4 in AML Cells Identifies a New Intronic Polymorphis"
... confirmed by sequencing DNA samples of 51 healthy individuals. Interestingly, this SNP had not yet been registered in any SNP databases despite of its high frequency of 20% in samples of patients ... Department of Biochemistry of the Charité, Berlin, Germany using the ABI PRISM Big Dye Terminator system (Applied Biosystems, Germany). Sequences were analyzed using the Chromas software (Technely-sium ... hCDC4 protein. Sequence analysis of hCDC4 exon 10 identifies a new intronic SNP During the analysis of exon 10 and adjacent intronic sequences we could for the first time identify a new single nucleotide...
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Báo cáo y học: " Transcriptome analysis of murine thymocytes reveals age-associated changes in thymic gene expression"
... immunoglobulin chains were also found to be significantly increased in aged thymocytes. Understanding the changes in gene expression in thymocytes with age may hold the key in determining thymocyte fate ... expression in thymocytes with age. As shown in Table 4, real time RT-PCR confirmed the increased levels of many of these genes identified in the array analysis. Moreover, Western blot analysis of thymo-cyte ... array analysis. For each array sample, the RNA was prepared from the purified thymocytes. The thymocytes were processed by using the RNEasy Mini Kit (Qiagen, Valencia, CA). Quality and quantity of...
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Tài liệu Báo cáo khoa học: Proteomic analysis of dopamine and a-synuclein interplay in a cellular model of Parkinson’s disease pathogenesis docx
... Methylpyridinium(MPP(+))- and nerve growth factor-induced changes in pro- and anti-apoptotic signaling pathways in SH-SY 5Y neuroblastoma cells. Brain Res 952, 98–110.42 Yuan Y, Jin J, Yang ... thatpossibly grouped together all the proteins differentiallyexpressed. Instead of validating every single protein bywestern blotting, we applied a different approach bysearching for known physical interactions ... changes in 23 proteinsProteomic investigations were conducted on b-gal anda-syn cells treated or not with dopamine, as describedabove. Statistical analysis, by two-way analysis of ββ-Actinα-SynucleinFig....
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Tài liệu Báo cáo Y học: Functional analysis of DM64, an antimyotoxic protein with immunoglobulin-like structure from Didelphis marsupialis serum pdf
... residues phenylalanine and tyrosine typical of the Ig-fold are bold in each domain.Fig. 5. Inhibition of in vivo myotoxicity of myotoxins I or II by DM64.Groups of four mice were injected intramuscularly ... first threedomains and are present in the inhibitory receptors of Fig. 6. Inhibition of in vitro cytotoxicity of myotoxins I or II by DM64.Cytotoxicity was analyzed in vitro using C2C12 skeletal ... Neutralizing interaction between heparinsand myotoxin II, a lysine 49 phospholipase A2from Bothropsasper venom. Identification of a heparin-binding and cytolytictoxin region by the use of synthetic...
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Tài liệu Báo cáo Y học: Functional analysis of a small heat shock/a-crystallin protein from Artemia franciscana docx
... Mchaourab, H.S. (1999) Folding pattern of thea-crystallin domain in aA-crystallin determined by site-directedspin labelling. J. Mol. B iol. 294, 561–577.68. To¨ro¨k, Z., Goloubinoff, P., Horva´th, ... [66], and disassembly of active unitsfrom an oligomeric (storage) state of a-crystallin wasproposed, upon structural analysis of aA-crystallin by site-directed spin labelling, as a model for ... denaturation of proteins in diapause/encysted Artemia embryos. Thispermits spontaneous and/or assisted refolding of proteins,the former a llowing rapid resumption of d evelopmentunder limiting e nergy...
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Báo cáo Y học: The analysis of the fine specificity of celiac disease antibodies using tissue transglutaminase fragments pot
... belongs to afamily of enzymes that catalyze protein cross-linking reac-tions and is constitutively expressed in many tissues as well asbeing activated during apoptosis. In a recent paper, ... indicatingeither a direct interaction with the triad amino acids or aconsequence of steric hindrance causing an interference in enzymatic activity. In conclusion, by analyzing individual phage antibodiesisolated ... recognizing gliadins, food proteinsand an endomysial autoantigen, identified as being tissuetransglutaminase (tTG) [3]. tTG or type 2 transglutaminaseis a member of a family of seven isoforms of...
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Báo cáo Y học: Structural analysis of Francisella tularensis lipopolysaccharide potx
... 2-N-(3-O-acyl4-acyl2)-b-GlcN-(1–6)-2-N-acyl1)3-O-acyl3-GlcN whereacyl1,acyl2and acyl3are 3-hydroxyhexadecanoic or 3-hy-droxyoctadecanoic acids, acyl4is tetradecanoic or (minor)hexadecanoic ... C-1, and wasmostly present in an a-pyranose form. Acyl1,acyl2and acyl3residues had hydroxy or acyloxy groups at C-3 (13C signals of C-3 at 69.0–72.4 p.p.m.), while acyl4had no substituents.The ... (C)p.p.m. can only be explained as resulting from the acylation of A3withacyl3. O-Acylation of GlcN A at O-3 and of acyl2at O-3 agreed with the low-field position of the correspond-ing proton signals...
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Báo cáo Y học: Structural analysis of deacylated lipopolysaccharide of Escherichia coli strains 2513 (R4 core-type) and F653 (R3 core-type) pot
... core-oligosaccha-rides of E. coli F653 LPS for which only preliminary datawere available and investigated the deacylated LPS byNMR and MS. The proposed structure determined pre-viously by methylation analysis ... Verhoef, J. & Sinnwell, V. (1988) Iolation and chemical analysis of 7-O-(2-amino-2-deoxy-a-D-glucopyranosyl-L-glycero-D-manno-heptose as a constituent of the lipopolysaccharides of theUDP-galactose ... determined as described [11].Preparation of deacylated LPS of E. coli2513LPS (5 g) was de-O-acylated by mild hydrazinolysis [7](yield 3.84 g) and 400 mg of the latter were subjected toalkaline...
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Báo cáo Y học: Kinetic analysis of hydroxylation of saturated fatty acids by recombinant P450foxy produced by an Escherichia coli expression system docx
... Kinetic analysis of hydroxylation of saturated fatty acidsby recombinant P450foxy produced by anEscherichia coliexpressionsystem7Tatsuya7Kitazume1, Akinori Tanaka1, Naoki Takaya1, ... substrate-accessing channel, and theirguanidinium and hydroxyl groups, respectively, play crucialroles in the binding of the substrate by interacting with thecarboxyl group of the substrate fatty acids ... Protein conxentration was determined using theBio-Rad protein assay reagent (Bio-Rad Laboratories Inc.,CA, USA).Data analysis Steady state kinetic analyses for P450foxy were examinedwith varying...
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