... Wallac,Turku, Finland1. The nitric oxide donors 1,1-diethyl-2-hydroxy-2-nitrosohydrazine sodium (DEA -NO) , 2,2¢-(hydroxynitrosohydrazono)bis-ethanamine (DETA -NO) and N-(2-aminoethyl)-N-(2-hydroxy-2-nitrosohydrazino)-1,2-ethylenediamine ... N-(2-ami-noethyl)-N-(2-hydroxy-2-nitrosohydrazino)-1,2-ethylenediamine.Enzymes: Nitric oxide synthase (EC 1.14.13.39); phosphotyrosine-specific phosphatase (EC 3.1.3.48); protein-tyrosine kinase(EC ... the NO •donor DEA -NO strongly inhibits this process in aFig. 1. NO •inhibits DNA synthesis by a cGMP-independent mechan-ism. Incorporation of [methyl-3H]thymidine into DNA was determinedas...